Preparation method of traditional Chinese medicine fermented anti-tumor active polypeptide oral liquid

A technology of anti-tumor activity and peptide oral liquid, which is applied in the field of preparation of traditional Chinese medicine fermentation anti-tumor active peptide oral liquid, can solve the problems of time, temperature, pressure, inaccurate curative effect, slow therapeutic effect, etc., and achieve simple and stable process High efficiency, beneficial to the metabolism and absorption of organisms, and the effect of improving curative effect

Inactive Publication Date: 2020-06-16
红华御康生物科技(江苏)股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is difficult to unify the time, temperature, and pressure of cooking traditional Chinese medicine at home, so it is difficult to determine the complete release of the active ingredients in the medicinal materials, and it is difficult to determine how much can be dissolved and released.
Therefore, the traditional Chinese medicine decoction made by the family will have the problem of slow therapeutic effect and inaccurate curative effect.

Method used

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  • Preparation method of traditional Chinese medicine fermented anti-tumor active polypeptide oral liquid
  • Preparation method of traditional Chinese medicine fermented anti-tumor active polypeptide oral liquid
  • Preparation method of traditional Chinese medicine fermented anti-tumor active polypeptide oral liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1. Raw material-cooking

[0039] 1. Material preparation: Weigh the required Chinese medicine raw materials

[0040] 15 parts of ganoderma lucidum, 30 parts of highland barley, 25 parts of yew extract, 14 parts of medlar, 15 parts of honey, 35 parts of kudzu rice, 25 parts of barley, 18 parts of shiitake mushroom, 20 parts of yam, 25 parts of hawthorn, pulverized by a grinder, Pour into cooking tank 1;

[0041] 3. According to the material: water = 1-6, add pure water, add the required amylase, glucoamylase, cellulase, and compound protease, maintain the temperature at 55 ° C, enzymolysis for 5 hours, stirring speed 200r / min, after the end of enzymolysis , heat up to 100°C, keep boiling for 30 minutes, pump the feed liquid into the yeast fermentation tank, wait until the temperature drops to 28°C, add yeast at 6%, ferment at 28°C for 84 hours, and then carry out acetic acid fermentation and add acetic acid bacteria at 8% , 28 ℃ constant temperature fermentation 48h. ...

Embodiment 2

[0055] 1. Raw material-cooking

[0056] 1. Material preparation: Weigh the required Chinese medicine raw materials

[0057] 45 parts of ganoderma lucidum, 18 parts of highland barley, 35 parts of yew extract, 14 parts of wolfberry fruit, 16 parts of honey, 40 parts of kudzu rice, 25 parts of barley, 20 parts of shiitake mushroom, 25 parts of yam, 35 parts of hawthorn, pulverized by a grinder, Pour into cooking tank 1;

[0058] 4. According to the material: water = 1:5, add pure water, add the required amylase, glucoamylase, cellulase, and compound protease, maintain the temperature at 65°C, enzymolysis for 5 hours, stirring speed 250r / min, after the end of enzymolysis , heat up to 100°C, keep boiling for 25 minutes, then pump the feed liquid into the yeast fermentation tank, wait until the temperature drops to 30°C, add yeast at 8%, ferment at 30°C for 66 hours, then carry out acetic acid fermentation and add acetic acid bacteria at 6% , 30 ℃ constant temperature fermentatio...

Embodiment 3

[0072] 1. Raw material-cooking

[0073] 1. Material preparation: Weigh the required Chinese medicine raw materials

[0074] 38 parts of ganoderma lucidum, 20 parts of highland barley, 40 parts of yew extract, 12 parts of medlar, 15 parts of honey, 38 parts of kudzu rice, 42 parts of barley, 36 parts of shiitake mushroom, 30 parts of yam, 25 parts of hawthorn, pulverized by a grinder, Pour into cooking tank 1;

[0075] 5. According to the material: water = 1:7, add pure water, add the required amylase, glucoamylase, cellulase, and compound protease, maintain the temperature at 65°C, enzymolysis for 4 hours, stirring speed 100r / min, after the end of enzymolysis , heat up to 100°C, keep boiling for 30 minutes, and pump the feed liquid into the yeast fermentation tank. When the temperature drops to 28°C, add yeast at 5%, ferment at 28°C for 96 hours, and then carry out acetic acid fermentation and add acetic acid bacteria at 6%. 28 ℃ constant temperature fermentation 48h.

[00...

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Abstract

The invention discloses a preparation method of traditional Chinese medicine fermented anti-tumor active polypeptide oral liquid. According to the method, effective components of traditional Chinese medicines are taken by microorganisms as precursors, a new compound is formed through microbial fermentation and metabolism, the microorganisms can also generate rich secondary metabolites in the growth process, and some secondary metabolites are medicines with good effects; or secondary metabolites of the microorganisms and some substances in the traditional Chinese medicines are subjected to a chemical reaction to generate new compounds. Various polypeptides and amino acids exist in the fermented solution and can be directly used by organisms, and the preparation method is simple, stable andefficient in process, suitable for industrial production and low in cost.

Description

technical field [0001] The invention belongs to the technical field of preparation of traditional Chinese medicines, relates to the preparation of anti-tumor polypeptides based on raw materials of traditional Chinese medicines, and more specifically relates to a method for preparing traditional Chinese medicine fermented anti-tumor active polypeptide oral liquids. Background technique [0002] Traditional Chinese medicine has a history of thousands of years in our country. Due to the backward processing technology of traditional Chinese medicine, especially the traditional Chinese medicine prescriptions prescribed by doctors of traditional Chinese medicine are basically boiled at home. In fact, the process of boiling is to dissolve the active ingredients in Chinese medicinal materials by boiling them. let go. However, it is difficult to unify the time, temperature, and pressure of home brewing of traditional Chinese medicine, so it is difficult to determine the complete rele...

Claims

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Application Information

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IPC IPC(8): A61K36/8998A61K9/08A61P35/00A61K35/644A61K35/748
CPCA61K9/0095A61K35/644A61K35/748A61K36/07A61K36/074A61K36/13A61K36/734A61K36/815A61K36/8945A61K36/899A61K36/8998A61K2236/19A61P35/00A61K2300/00
Inventor 蒋佩华
Owner 红华御康生物科技(江苏)股份有限公司
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