Preparation method and application of a silicate-based long-lasting probe

Abstract

The invention discloses a preparation method and an application of a silicate long afterglow probe. Mesoporous silicon dioxide is used as a template, zinc nitrate, gallium nitrate, germanium nitrate,ytterbium nitrate, chromic nitrate and erbium nitrate are used as doped metal raw materials, the doped metal raw materials are dissolved in water and uniformly mixed, the mixture is dropwise added into the mesoporous silicon dioxide, roasting is performed at high temperature, and a pre-product is obtained after roasting is finished; then, functional modification is performed on the surface of thepre-product, and hydroxylation, amination and PEG modification are sequentially performed to obtain a modified pre-product; and finally, a photosensitizer silicon dichloride phthalocyanine is loaded to obtain the silicate long afterglow probe. The silicate long-afterglow probe has good biological safety, after caudal vein injection and under X-ray irradiation, a tumor area is effectively enriched,deep in-situ tumor imaging is achieved, in-situ tumor cells are seriously killed, and finally diagnosis and treatment integration of the silicate long-afterglow probe on deep tumors is achieved.

Description

Technical field [0001] The present invention belongs to the treatment of diagnostic techniques for in situ liver cancer, and is specifically related to the preparation method of long-resting probes of silicates and their applications. Background technique [0002] Cancer, as one of the main threats of human life, in recent decades, the growth rate has been increasing, and has become a major illness that seizes human life. Among them, liver cancer is known as "king of cancer" in my country, while liver cancer is also known as the fifth largest and female cancer of men, and more than half of the new cases in the world will occur in my country. Liver cancer has become a major disease and socially health burden affecting the health of my country's health. As a result, effective prevention, diagnosis and treatment of liver cancer is the urgent task of biomedical research. At present, the main effective means for the treatment of liver cancer is surgical resection and liver transplanta...

AI Technical Summary

Problems solved by technology

However, long-lasting luminescent materials also have certain limitations, that is, the excitation light source is usually a high-energy ultraviolet irradiation material to achieve afterglow luminescence. The biggest limitation of ultraviolet light in biomedical imaging is that the penetration depth of the light source is too shallow to perform deep imaging

In recent years, researchers have used near-infrared light as an excitation light source to overcome the problem of penetration depth, but the energy of near-infrared light is not enough to achieve good afterglow luminescence, and imaging can only be achieved in a short time

Images