Anti-inflammatory and anti-bacterial composition
A technology of composition and application, applied in the direction of anti-inflammatory agent, antibacterial drug, antifungal agent, etc., can solve the problem of incompetence in the treatment of exogenous damage, etc., achieve less adverse skin side effects, significant clinical value, and inhibit inflammatory response Effect
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Embodiment 1
[0039] Example 1. Evaluation of antibacterial activity of dichlorobenzyl alcohol aerosol
[0040] Under A-level purification conditions, dissolve 0.1g of 2,4-dichlorobenzyl alcohol (BASF) in 2g of ethanol, stir for 10 minutes, let stand, filter, and transfer to the storage tank with anticorrosive coating. In the pressure tank, the top of the tank is installed with a valve and capped and sealed, and 1,1,1,2-tetrafluoroethane and 1,1,1,3,3-pentafluoropropane are carried out at a weight ratio of 10:90 Premix as a propellant. After mixing, pour 98g of the above-mentioned propellant into the tank under pressure, install an actuator on the valve nozzle, and send it to the Class B purification zone, cover it, and send it to the Class C purification zone for inspection. Thus, the aerosol of dichlorobenzyl alcohol was obtained as the test group. A negative control group (distilled water) and a positive control group (75% alcohol) are also set up.
[0041] Further, the following method (se...
Embodiment 2
[0045] Example 2. Evaluation of anti-inflammatory activity of dichlorobenzyl alcohol aerosol on mouse ear swelling
[0046] Take 40 healthy male mice (obtained from Chengdu Dashuo Experimental Animal Co., Ltd.) and randomly divide them into 4 groups. Each mouse's right ear was coated with 10μl of xylene to cause inflammation, and the left ear was used as a normal control. The four groups were treated with normal saline (Sichuan Kelun Pharmaceutical Co., Ltd.), aqueous dichlorobenzyl alcohol (0.2%), iodophor (Chengdu Zhongguang Decontamination Co., Ltd.), and chlorhexidine (Chengdu Zhongguang Guang Decontaminant Co., Ltd.), dichlorobenzyl alcohol aerosol (for the preparation method see
[0047] In Example 1, about 1 ml of continuous spraying for 1 second). The mice were sacrificed 4 hours after the inflammation. A 9mm diameter punch was used to punch round ear pieces on the same part of both ears and weighed. The swelling degree was calculated based on the weight difference betwee...
Embodiment 3
[0052] Example 3. Evaluation of the therapeutic activity of dichlorobenzyl alcohol aerosol on skin boils
[0053] Take 50 SPF-grade SD rats (obtained from Chengdu Dashuo Experimental Animal Co., Ltd.), routinely depilate their backs, with an area of about 5×6cm 2 10 of them were treated as normal control group without any treatment, 40 of them used a scalpel to cut the skin deep to the full thickness, about 1.5cm in length, and injected 2×10 subcutaneously 10 Staphylococcus aureus stock solution (ATCC6538) 0.5mL, smear Staphylococcus aureus around the incision. After 48 hours, the modeled animals were slow in activity, weight loss, redness and swelling around the wound, light tenderness, and purulent discharge appeared in the wound. Model rats were randomly divided into 4 groups according to the diameter of skin boils, with 10 rats in each group. The first group is the model group, the second group is the iodophor group, the third group is the chlorhexidine group, and the fourt...
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