Controlled-release antibiotic expanded acrylic bone cement and preparation method thereof

A technology of antibiotics and bone cement, applied in the field of medical biomaterials, can solve the problems of low antibiotic release rate, achieve high expansion ratio and antibiotic release rate, long antibiotic release cycle, and reduce pain

Active Publication Date: 2020-06-23
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] An object of the present invention is to provide a controlled-release antibiotic-expandable acrylic bone cement, which solves the problem of low antibiotic release rate of the existing antibiotic-loaded bone cement

Method used

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  • Controlled-release antibiotic expanded acrylic bone cement and preparation method thereof

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preparation example Construction

[0042] A kind of preparation method of controllable-release antibiotic expansion acrylic acid bone cement of the present invention comprises the following steps:

[0043] Step 1, prepare carboxylated graphene

[0044] Step 1.1, weigh graphene oxide, sodium hydroxide and monochloroacetic acid according to the mass ratio of 0.05~0.2:3~6:2~5, and mix graphene oxide with water to make the concentration 0.25mg / ml~2mg / ml ml of graphene oxide aqueous solution;

[0045] Step 1.2, ultrasonically disperse the graphene oxide aqueous solution to obtain a GO suspension, then add the weighed sodium hydroxide and monochloroacetic acid into the GO suspension and mix evenly, filter the mixed solution to obtain a solid product, and dry the solid product Finally, carboxylated graphene is obtained.

[0046] Step 2, preparation of polymethyl methacrylate-itaconic acid-carboxylated graphene-loaded antibiotic microspheres

[0047] Step 2.1, according to the mass ratio of 10:26:0.09~1.08:1.8~2.88:...

Embodiment 1

[0058] The preparation of a controlled-release antibiotic expanded acrylic bone cement comprises the following steps:

[0059] Step 1, prepare carboxylated graphene

[0060] Step 1.1, weigh 50mg graphene oxide (GO), 3g sodium hydroxide (NaOH) and 2g monochloroacetic acid (C 2 h 3 ClO 2 ), disperse 50mg graphene oxide (GO) in 100ml distilled water, make the graphene oxide aqueous solution that concentration is 0.5mg / ml;

[0061] Step 1.2, ultrasonically disperse the graphene oxide aqueous solution at room temperature for 1 hour to obtain a GO suspension; add the weighed sodium hydroxide and monochloroacetic acid into the GO suspension and shake for 3 hours, and wait until they are mixed evenly and after the reaction is complete, Filter the mixed solution to obtain a solid product, and dry the solid product at 70° C. for 48 hours to obtain carboxylated graphene (CG);

[0062] Step 2: Preparation of polymethyl methacrylate-itaconic acid-carboxylated graphene-loaded antibiotic...

Embodiment 2

[0075] The preparation of a controlled-release antibiotic expanded acrylic bone cement comprises the following steps:

[0076] Step 1, prepare carboxylated graphene

[0077] Step 1.1, weigh 200mg graphene oxide (GO), 6g sodium hydroxide (NaOH) and 5g monochloroacetic acid (C 2 h 3 ClO 2 ), disperse 200mg graphene oxide (GO) in 200ml distilled water, make the graphene oxide aqueous solution that concentration is 1mg / ml;

[0078] Step 1.2: Ultrasonic disperse the graphene oxide aqueous solution at room temperature to obtain a GO suspension; add the weighed sodium hydroxide and monochloroacetic acid into the GO suspension and shake for 5 hours, wait until they are evenly mixed, and after the reaction is complete, filter A solid product was obtained from the mixed solution, and the solid product was dried at 90° C. for 24 hours to obtain carboxylated graphene (CG);

[0079] Step 2: Preparation of polymethyl methacrylate-itaconic acid-carboxylated graphene-loaded antibiotic mic...

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Abstract

The invention discloses controlled-release antibiotic expanded acrylic bone cement prepared by mixing a solid phase and a liquid phase according to a ratio of 1g: (0.6ml-0.9ml), wherein the solid phase includes polymethyl methacrylate, antibiotic loaded microspheres with expandable core-shell structures and barium sulfate which are in the mass ratio of (5-7): (2.1-4.5): (0.5-0.9), and the antibiotic loaded microspheres with expandable core-shell structures contain carboxylated graphene; and the liquid phase includes methyl methacrylate, an accelerant and a retardant which are in the mass ratioof (8.5-9.5): (0.25-0.5): (0.25-1). The invention further discloses a preparation method of the controlled-release antibiotic expanded acrylic bone cement. The bone cement prepared by using the method has a better expansion ratio, also has a sensitive pH response function and is capable of realizing long-acting drug release as required according to the pH change of a microenvironment surroundingan implant, so that the release ratio of antibiotics is increased.

Description

technical field [0001] The invention belongs to the technical field of medical biomaterials, and relates to a controlled-release antibiotic expanded acrylic bone cement and a preparation method thereof. Background technique [0002] Acrylic bone cements are now widely used, the most common of which is polymethyl methacrylate (PMMA) bone cement. Due to its good mechanical properties and injectability, PMMA bone cement is regarded as the "gold standard" for vertebral body filling, hip replacement, knee replacement and dental surgery. As a mature clinical filler and foreign implant, PMMA bone cement needs to be equipped with different types of antibiotics to cause certain effects on various acute and chronic bone and joint infections caused by osteomyelitis, joint replacement surgery, traumatic fracture surgery of extremities, etc. Prevention and treatment. PMMA bone cement loaded with antibiotics is an indispensable and key medical material for the clinical treatment of bone...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/02A61L27/08A61L27/54
CPCA61L27/16A61L27/025A61L27/08A61L27/20A61L27/54A61L2300/406A61L2300/602A61L2300/624A61L2430/02C08L33/12C08L5/04
Inventor 汤玉斐陈磊张博赵康吴子祥
Owner XIAN UNIV OF TECH
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