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ICP-MS detection method for content of soluble lead in montmorillonite powder

A detection method, the technology of montmorillonite powder, applied in the field of chemical analysis, can solve the problem of incomplete extraction of lead elements, etc., and achieve the effect of high accuracy, simple sample pretreatment, and less interference

Pending Publication Date: 2020-06-26
HAINAN SIMCERE PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the treatment of montmorillonite samples, the acid digestion method is often used to extract the lead element. Because of its adsorption and layered structure, the commonly used acid digestion method cannot completely extract the lead element.
Therefore, consider using the leachable lead content in the digestive system to assess the toxicity of its oral administration route, and provide control limits accordingly

Method used

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  • ICP-MS detection method for content of soluble lead in montmorillonite powder
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  • ICP-MS detection method for content of soluble lead in montmorillonite powder

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] 1) Selection of instruments and reagents.

[0059] Instruments: inductively coupled plasma mass spectrometer (7900, Agilent Technologies Co., Ltd.), analytical balance, dissolution apparatus.

[0060] Reagents: high-grade pure nitric acid, high-grade pure sulfuric acid, chromatographically pure hydrochloric acid, analytically pure sodium chloride, analytically pure pepsin (Aladdin Reagent (Shanghai) Co., Ltd.), lead standard stock solution with a concentration of 1000mg / L.

[0061] Preparation of simulated gastric juice: Take 2.0g of sodium chloride and 3.2g of pepsin, add 80mL of 1M hydrochloric acid and water to dissolve to 1000mL, and obtain gastric simulated solution. The pH of the solution was 1.2.

[0062] The parameters of the inductively coupled plasma mass spectrometer are:

[0063] RF power: 1500W;

[0064] Plasma gas flow rate: 15L / min;

[0065] Carrier gas flow rate (argon): 0.8L / min;

[0066] Helium gas flow: 4mL / min~5mL / min;

[0067] Spray chamber te...

Embodiment 2

[0079] 1) Selection of instruments and reagents.

[0080] Instruments: inductively coupled plasma mass spectrometer (7900, Agilent Technologies Co., Ltd.), analytical balance, dissolution apparatus.

[0081] Reagents: superior pure nitric acid, superior pure sulfuric acid, chromatographically pure hydrochloric acid, analytically pure sodium chloride, analytically pure pepsin (Aladdin Reagent (Shanghai) Co., Ltd.).

[0082] Preparation of simulated gastric juice: Take 2.0g of sodium chloride and 3.2g of pepsin, add 80mL of 1M hydrochloric acid and water to dissolve to 1000mL, and obtain gastric simulated solution. The pH of the solution should be 1.2.

[0083] The parameters of the inductively coupled plasma mass spectrometer are:

[0084] RF power: 1500W;

[0085] Plasma gas flow rate: 15L / min;

[0086] Carrier gas flow rate (argon): 0.8L / min;

[0087] Helium gas flow: 4mL / min~5mL / min;

[0088] Spray chamber temperature: 2°C;

[0089] Sample lift rate: 0.3r / s;

[0090]...

Embodiment 3

[0102] 1) Selection of instruments and reagents.

[0103] Instruments: inductively coupled plasma mass spectrometer (7900, Agilent Technologies Co., Ltd.), analytical balance, dissolution apparatus.

[0104] Reagents: high-grade pure nitric acid, high-grade pure sulfuric acid, chromatographically pure hydrochloric acid, analytically pure sodium chloride, analytically pure pepsin (Aladdin Reagent (Shanghai) Co., Ltd.), lead standard stock solution with a concentration of 1000mg / L.

[0105] Preparation of simulated gastric juice: Take 2.0g of sodium chloride and 3.2g of pepsin, add 80mL of 1M hydrochloric acid and water to dissolve to 1000mL, and obtain gastric simulated solution. The pH of the solution should be 1.2.

[0106] The parameters of the inductively coupled plasma mass spectrometer are:

[0107] RF power: 1500W;

[0108] Plasma gas flow rate: 15L / min;

[0109] Carrier gas flow rate (argon): 0.8L / min;

[0110] Helium gas flow: 4mL / min~5mL / min;

[0111] Spray cham...

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Abstract

The invention belongs to the field of chemical analysis, and relates to an ICP-MS detection method for the content of soluble lead in montmorillonite powder. The method comprises the following steps:A, mixing montmorillonite powder with simulated gastric juice to obtain a test solution; B, detecting the test solution by using an inductively coupled plasma mass spectrometer. The method can be usedfor evaluating the toxicity of lead in montmorillonite powder. The ICP-MS is adopted for detecting the content of the soluble lead in the montmorillonite powder; the method is simple, rapid, good inlinearity, low in detection limit, high in accuracy and good in repeatability; RSD meets the requirement, sample pretreatment is simple, and interference is little.

Description

technical field [0001] The invention belongs to the field of chemical analysis, and relates to a method for detecting soluble lead content in montmorillonite powder, in particular to a method for detecting the soluble lead content by using ICP-MS. Background technique [0002] Elemental lead is a substance that is toxic to humans and has been restricted or no longer used in pharmaceutical production. However, montmorillonite is a naturally occurring hydrous layered aluminosilicate mineral. In an aqueous dispersion system, the interlayer cations of montmorillonite can be replaced by other cations or positively charged groups in the solution. In soil, it is easy to adsorb cations such as calcium, magnesium, and lead, so natural montmorillonite often contains heavy metal lead. [0003] The limit requirements for heavy metals in medicines in various countries are becoming more and more stringent. ICH issued Q3D in December 2014, and the PDE requirement for lead oral administrat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/62
CPCG01N27/62
Inventor 余庆祝刘超陈荣任晋生
Owner HAINAN SIMCERE PHARMA CO LTD
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