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A kind of stevioside metal copper complex and preparation method thereof

A technology of steviolbioside and metal copper, which is applied in the field of preparation of metal complexes, and achieves the effects of strong operability, excellent DPPH removal and low cost

Active Publication Date: 2021-04-06
JIANGXI HAIFU BIOENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Therefore, steviobioside is formed by coordination and complexation with the beneficial metal copper element to develop a steviobioside metal copper complex. The products and methods in this regard have not been reported yet, and the high added value of researching stevioside The product has great significance and economic value

Method used

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  • A kind of stevioside metal copper complex and preparation method thereof
  • A kind of stevioside metal copper complex and preparation method thereof
  • A kind of stevioside metal copper complex and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] 1. Dissolution: fully dissolve 100 g of steviolbioside with a content of 85.2 wt% in 400 ml of 95% ethanol, dissolve 15 g of basic copper sulfate in 120 ml of an apple aqueous solution with a pH of 6.0, and fully stir to dissolve.

[0061] 2. Reaction: Mix the two solutions in step 1 and adjust the pH to 8.0 with ammonia water, then add 0.3 g of triethanolamine with stirring and react at a constant temperature of 60°C for 8 hours.

[0062] 3. Crystallization: Cool the reaction solution in step 2 to 10°C, let the crystal continue to grow, and keep it for 24 hours, then separate the crystal from solid and liquid by suction filtration, and use 90% ethanol at -4°C Rinse the extract until the eluate is colorless.

[0063] 4. Drying: Place the obtained crystals in a blast drying oven at 55°C for pre-drying until there is no obvious alcohol smell, then raise the temperature to 80°C and continue drying to constant weight. Promptly obtain 89.6g steviolbioside metal copper compl...

Embodiment 2

[0065] 1. Dissolution: fully dissolve 100g of 85.twt% steviolbioside in 600ml of 90% methanol, dissolve 15g of basic copper chloride in 150ml of citric acid solution with a pH of 6.0, and fully stir to dissolve.

[0066] 2. Reaction: Mix the two solutions in step 1 and adjust the pH to 8.0 with ammonia water, then add 0.4 g of tripropylamine, and react with stirring at a constant temperature of 80°C for 10 hours.

[0067] 3. Crystallization: Cool the reaction liquid in step 2 to -4°C, let the crystal continue to grow, and keep it for 12 hours, then separate the crystal from solid and liquid by suction filtration, and use 90% of the -4°C Methanol was used to rinse the leaching until the eluent was colorless.

[0068] 4. Drying: Place the obtained crystals in a vacuum drying oven with a vacuum degree of -0.8Mpa and a temperature of 45°C for pre-drying until there is no obvious alcohol smell, and then raise the temperature to 60°C and continue drying to constant weight. That is,...

Embodiment 3

[0070] 1. Dissolution: Fully dissolve 100g of steviolbioside with a content of 85.2wt% in 800ml of 90% isopropanol, dissolve 15g of basic copper chloride in 150ml of a citric acid solution with a pH of 6.0, and stir well to dissolve .

[0071] 2. Reaction: Mix the two solutions in step 1 and adjust the pH to 8.0 with ammonia water, then add 0.3 g of 4-aminotoluene-3-sulfonic acid, and react with stirring at a constant temperature of 75° C. for 10 h.

[0072] 3. Crystallization: Cool the reaction solution in step 2 to 0°C, let the crystal continue to grow, and keep it for 16 hours, then separate the crystal from solid and liquid by suction filtration, and use 90% isopropyl alcohol at 0°C Alcohol was used to rinse the extract until the eluate was colorless.

[0073] 4. Drying: Place the obtained crystals in a vacuum oven with a vacuum degree of -0.1Mpa and a temperature of 40°C for pre-drying until there is no obvious alcohol smell, and then raise the temperature to 80°C and co...

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Abstract

The invention provides a steviolbioside metal copper complex and a preparation method thereof. The structure of the stevioside metal copper complex is shown in formula (I), and the metal copper complexation rate is above 77%. The preparation method of the steviolbioside metal copper complex is to dissolve the steviolbioside in lower alcohol, dissolve the copper salt in the organic acid aqueous solution, mix the two solutions, adjust the pH to be weakly alkaline, and add the auxiliary complex Mixture, heated and stirred, the reaction solution cooled and crystallized, suction filtered, washed, and dried to obtain steviolbioside copper complex. Among the complexes formed by steviolbioside and metals, the complexes formed by steviolbioside and metal copper have obvious advantages in antioxidant effect, while the complexes formed by other metals and steviolbioside have no obvious antioxidant effect effect, highlighting the advantages of the steviolbioside metal copper complex provided by the invention.

Description

technical field [0001] The invention relates to a preparation method of a metal complex, in particular to a steviolbioside metal copper complex and a preparation method thereof. Background technique [0002] Metal complexes are a class of complexes formed by ligands and metal ions through coordination bonds. In recent years, scholars at home and abroad have done some research on the activity of metal complexes of traditional Chinese medicine, mainly in the aspects of antioxidant activity, antitumor activity and antibacterial effect of metal complexes of traditional Chinese medicine. In general, metal complexes of traditional Chinese medicines show certain advantages in these aspects. Generally, metal complexes of traditional Chinese medicines have more significant effects than the original active ingredients. [0003] Metal complexes are composed of ligands and metal ions, and atoms such as nitrogen, oxygen, sulfur, phosphorus, and halogen at the coordination site have str...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/256C07H1/00A61P39/06
CPCA61P39/06C07H1/00C07H15/256
Inventor 何安乐李伟黄华学
Owner JIANGXI HAIFU BIOENG
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