The invention provides a multi-purpose sterilizing combination for crops. The constituents has weight percentages that: constituent A is 1-50 percent, constituent B is 5-63 percent, constituent C is 0.1-5 percent, common carrier is 25-88 percent, and common assistant is 5.0-25 percent. The constituent A is any one of difenoconazole, prochloraz, prochloraz manganic salt, or metalaxyl-m. The constituent B is any one of basic copper sulfate, bluestone, copper hydroxide, copperchloride, cuprous oxide, copper acetate, cuaminosulfate, amber glue copper adipic acid, or copper rosinate. The constituent C is any one of diethyl aminoethyl hexanoate, sodium nitrophenolate, naphthyl acetic acid, gibberellins, or brassinosteroids lactone. The invention not only can multiply the expansion of the preventing spectrum on the crop disease, can delay the produce of the drug-resistance; can lower the dosage of each agent in the combination, can obviously improve the medical effect of the constituents when being used separately, can prevent and cure the disease, can facilitate the growth of the crop, and can increase the yield and the harvest of the crop.