Preparation method of andrographolide enteric-coated tablet
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A technology of andrographolide and enteric-coated tablets, which is applied in the field of medicine, can solve problems such as easy degradation, and achieve the effects of improving bioavailability, taking convenience, and ensuring curative effect
Pending Publication Date: 2020-07-03
HUANGSHAN C KING PHARMA
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[0004] Aiming at the deficiencies of the prior art, the present invention provides a preparation method of andrographolide enteric-coated tablets, which solves the problem that the existing andrographolide dispersible tablets are easily degraded in gastric juice
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preparation example Construction
[0041] The invention discloses a preparation method of andrographolide enteric-coated tablets, which specifically comprises the following steps:
[0042] (1) Preparation of tablet core
[0043] Dissolve hydroxypropyl cellulose with 20% to 95% ethanol aqueous solution, and then add sodium lauryl sulfate to prepare a solution with a solid content of 3% to 15% as a binder;
[0044] After sieving andrographolide, lactose and microcrystalline cellulose, add them to the high-speed mixing wet granulation device and mix them, then add the prepared binder for granulation; then add the prepared drug granules to the boiling dryer for drying , the water content is controlled at 2% to 5%; then the dried drug granules are sized with a granulator, and finally compressed with a high-speed rotary tablet machine to obtain the core of andrographolide enteric-coated tablets; andrographolide , Lactose and microcrystalline cellulose are routinely selected according to the actual situation.
[004...
Embodiment
[0064] The above method was used to prepare andrographolide enteric-coated tablets, and the specific composition ratios are shown in Table 1 below.
[0065] Table 1 Raw material ratio (parts by weight)
[0066]
[0067] Tablet cores were prepared according to the proportions in Table 1. The parameters during the operation of the high-speed mixing wet granulation device are shown in Table 2 below. The proportions of each group in the above Table 1 were prepared using the parameters set in Table 2 below. .
[0068] Table 2 Concrete Process Parameters
[0069]
[0070] After the preparation of the tablet core is completed, the tablet core is coated with an isolation layer and an enteric-coated layer, and the process parameters of the coating machine during the process of coating the isolation layer and the enteric-coated layer are shown in Table 3 below.
[0071] The process parameter of table 3 coating machine
[0072]
[0073] After each group of raw materials in th...
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Abstract
The invention relates to the technical field of medicines, and in particular relates to a preparation method of an andrographolide enteric-coated tablet. The specific technical scheme is as follows: the method for preparing the andrographolide enteric-coated tablet comprises the following steps: adding an adhesive, andrographolide, lactose and microcrystalline cellulose into a high-speed mixing wet-process granulating device to perform mixing and granulating; then adding the prepared medicine particles into a boiling dryer for drying, wherein the water content is controlled to be 2-5%; granulating the dried medicine particles by using a granulating machine, and finally performing tabletting by using a high-speed rotary tabletting machine to obtain a tablet core of the andrographolide enteric-coated tablet; and coating the tablet core of the enteric-coated tablet with an isolation layer and an enteric-coated layer. The invention solves the problem that the prior andrographolide dispersible tablets are degraded easily in gastric juice.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method of andrographolide enteric-coated tablets. Background technique [0002] Andrographolide, molecular formula C 20 h 30 o 5 , the main active ingredient of the natural plant Andrographis paniculata, has the effects of dispelling heat and detoxification, reducing inflammation and relieving pain, and has special curative effects on bacterial and viral upper respiratory tract infections and dysentery. It is known as a natural antibiotic drug. [0003] Andrographolide preparations for clinical application mainly include andrographolide tablets, andrographolide soft capsules, andrographolide dripping pills, and andrographolide dispersible tablets, all of which are gastric-soluble preparations. The test results of Andrographolide Tablets, Andrographolide Soft Capsules, Andrographolide Dropping Pills, and Andrographolide Dispersible Tablets under weak acid conditi...
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