Ketogenic diet composition for preventing and/or treating demyelination disease as well as preparation method and application of composition
A technology of ketogenic diet and composition, which is applied in the field of ketogenic diet composition and its preparation for the prevention and/or treatment of demyelinating diseases, which can solve the problems of incomplete cure and few problems, and achieve the maintenance of intestinal Balance the internal microecology, promote reproduction and growth, and improve the effect of intestinal microecology
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Embodiment 1
[0095] Ketogenic diet can reduce weight loss induced by CPZ group
[0096]In the Ctrl group, the average body weight of the mice gradually increased, while the body weight of the CPZ group decreased ( Figure 1A ). On days 7, 14, 21, 28, and 35 after CPZ induction, there were significant differences in mean body weight between the Ctrl group and the CPZ group ( Figure 1B , p Figure 1B , p<0.001). A ketogenic diet can reduce CPZ-induced weight loss.
Embodiment 2
[0098] Ketogenic Diet Reverses Abnormal Behavior Caused by CPZ
[0099] In the open field test, the anxiety and exploration ability of the mice were evaluated by measuring the total distance traveled by the mice, the distance traveled in the central area, and the time spent in the central area. In the CPZ model, it has been reported that the ability of CPZ mice to explore in the central area is reduced and anxiety is increased (Yu, H., Wu, M., Lu, G., Cao, T., Chen, N., Zhang ,Y.,Jiang,Z.,Fan,H.,&Yao,R.(2018).Prednisone induces demyelination through regulation of the NLRP3inflammasome in a C57BL / 6mouse model of cuprizone-induced demyelination.Brain Res,1678,75-84.) . The results of the study showed that after CPZ feeding for 5 weeks, compared with Ctrl, the total distance moved by the mice, the total distance moved by the central area and the time spent in the central area were significantly reduced ( Figure 2B ). May be related to anxiety caused by demyelination. After 5...
Embodiment 3
[0101] Blood sugar and ketone body detection and analysis
[0102] The results of the study showed that compared with the CPZ group, the serum β-hydroxybutyrate and blood ketone levels were significantly increased in the KD+CPZ group (pimage 3 A and 3B). In addition, compared with the CPZ group and the Ctrl group, the blood glucose level in the KD+CPZ group was significantly lower (pimage 3 C). The above results indicated that the ketogenic diet decreased blood glucose concentration, increased blood ketone concentration and serum β-hydroxybutyric acid.
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