93 results about "Ketone concentration" patented technology

This invention relates to the field of therapeutic agents for the treatment of Age-Associated Memory Impairment (AAMI). In particular, the present invention utilizes compositions comprising at least one compound capable of elevating ketone body concentrations in a mammal (e.g., ketogenic compounds), administered in an amount effective for treatment or prevention of loss of cognitive function caused by reduced neuronal metabolism in AAMI. In one embodiment, the composition includes medium chain triglycerides (MCT). In another embodiment, the compositions are administered in the presence of carbohydrate. The present invention also relates to oral dosage forms, in particular, a nutritional drink comprising at least one compound capable of elevating ketone body concentrations in a mammal.

The subject disclosure provides compositions for reducing serum cholesterol and/or triglyceride levels in subjects. These compositions can comprise racemic β-hydroxybutyrate or D-β-hydroxybutyrate, optionally in the acid form, physiologically compatible salts of racemic β-hydroxybutyrate or D-β-hydroxybutyrate, esters of D-β-hydroxybutyrate, oligomers of D-β-hydroxybutyrate containing from 2 to 20 or more monomeric units in either linear or cyclic form, racemic 1,3 butandiol or R-1,3 butandiol alone and can be, optionally, administered in conjunction with a low fat diet to a subject. Alternatively, compositions comprising racemic β-hydroxybutyrate or D-β-hydroxybutyrate, optionally in the acid form, physiologically compatible salts of racemic β-hydroxybutyrate or D-β-hydroxybutyrate, esters of D-β-hydroxybutyrate, oligomers of D-β-hydroxybutyrate containing from 2 to 20 or more monomeric units in either linear or cyclic form, racemic 1,3 butandiol, R-1,3 butandiol or combinations thereof can be formulated as nutritional supplements (also referred to as nutritional compositions) or incorporated into therapeutic compositions containing a) anti-hypertensive agents; b) anti-inflammatory agents; c) glucose lowering agents; or d) anti-lipemic agents) which are administered to a subject, optionally in combination with a low fat diet, in order to cause a reduction or lowering of: serum cholesterol levels; triglyceride levels; serum glucose levels, serum homocysteine levels, inflammatory proteins (e.g., C reactive protein) and/or hypertension in treated subjects. Alternatively, compositions disclosed herein can be administered alone, or in combination with other therapeutic agents to prevent or reverse vascular disease.

A sensing device having a first and second opening, a first semipermeable membrane having a first surface and a second surface, and a second semipermeable membrane having a third and fourth surface, a ketone body sensor, and a void. The first opening is juxtaposed to the first surface and the second opening is juxtaposed to the third surface. The space between the first and second openings is the void and wherein the ketone body sensor is positioned within the void. Gasses may permeate through the first opening and into the void to contact the sensor and exit the void through the second opening.

Disposable test strips and a wet chemistry method for measuring each of beta-hydroxybutyrate alone, combined beta-hydroxybutyrate and acetoacetate or total ketone bodies (i.e., beta-hydroxybutyrate, acetoacetate and acetone) in human bodily fluid samples, including but not limited to urine, saliva or sweat are described. The test strips need only be dipped in the sample and can be used by anyone in almost any milieu. Measurement can be made electrochemically, spectrophotometrically, fluorometrically or by comparision to a color standard. Combined acetoacetate and beta-hydroxybutyrate which account for 97-98% of total ketone bodies and may be measured in a cyclic reaction that occurs at pH about 7.0 to about 8.3 with beta-hydroxybutyrate dehydrogenase, (beta-HBD), nicotinamide adenine dinucleotide, a tetrazolium dye precursor and an electron mediator. Using this reaction, false positive results obtained from urine samples taken from patients on sulfhydryl drugs are avoided. beta-HBD from some sources was found to cause false negative results in samples (e.g. urine) containing high chloride content due to chloride inhibition of beta-HBD. Using a simple test for chloride inhibition, it was found that beta-HBD from Alcaligenes is not so inhibited. Using either beta-HBD that is not inhibited by chloride or using 10-20 times the normal concentration of this enzyme eliminates false negatives in samples having substantial chloride content, such as urine, both in the reaction described above and in other reactions disclosed for measuring each of beta-hydroxybutyrate alone, combined beta-hydroxybutyrate and acetoacetate and total ketone bodies, all of which reactions occur in the pH range of about 8.6 to about 9.5.

Ketogenic compositions including a non-racemic mixture of beta-hydroxybutyrate (BHB) enriched with the S-enantiomer are formulated to control ketone body levels in a subject. The non-racemic mixture of BHB is enriched with the S-enantiomer to modulate the effect of ketone bodies in the subject and control the rate at which ketosis is achieved. In some aspects a composition for controlling ketone body level in a subject contains a dietetically or pharmaceutically acceptable carrier and a non-racemic mixture of S-beta-hydroxybutyrate and R-beta-hydroxybutyrate, wherein the non-racemic mixture contains from about 52% to 99% by enantiomeric equivalents of S-beta-hydroxybutyrate enantiomer and from about 48% to about 1% by enantiomeric equivalents of R-beta-hydroxybutyrate enantiomer.

Ketoacidosis is a medical emergency that requires swift intervention to avert life-threatening sequel. A body-worn sensor (50) configured to measure the levels of a ketone compound circulating in a physiological fluid of a wearer and capable of generating an alert to the wearer if the level of the circulating ketone compound exceeds a pre-defined level or rate of change is disclosed herein. The sensor (50) preferably includes at least one of an electrochemical sensor, an optical sensor, a galvanic sensor, a voltammetric sensor, an amperometric sensor, a potentiometric sensor, an impedimetric sensor, a resistive sensor, a capacitive sensor, an ultrasonic sensor, a radio-frequency sensor, or a microwave sensor.

The invention provides feed for improving ketone body quality of broilers. The feed comprises a main feed component, galactomannan, betaine, chromium nicotinate, soya bean lecithin, bee pollen, bone meal, sodium bicarbonate, lucerne meal, an amino acid additive, a vitamin additive, a traditional Chinese medicine feed additive for improving the ketone body quality and flavor of the broilers, and a microbe preparation. The traditional Chinese medicine feed additive and the feed for improving the ketone body quality and flavor of the broilers, which are provided by the invention, have the effects of low toxicity, no side effect and no residue, and can significantly improve the ketone body quality and flavor of the broilers.

The invention provides a physical change evaluation device, method, and program capable of easily evaluating physical change from the past to the present, and from the present into the future.

A physical change evaluation device 10 acquires a ketone concentration measurement measuring ketone excreted from a user, acquires physical data relating to the body of the user, evaluates physical change in the user based on the acquired ketone concentration measurement and the physical data, and outputs an evaluation result.

The invention provides an analyte monitoring and automatic drug administrating system. The system comprises a detection unit, a processing unit, a calculation unit, an injection unit and a control unit. The detection unit comprises at least two detection parts, and each detection part is used for detecting an analysis object in analyte. The injection unit injects drugs according to the total drug injection amount calculated through the calculation unit, the injection unit comprises at least two injection parts, and each injection part is used for injecting the drugs. The control unit controls the detection unit, the processing unit, the calculation unit and the injection unit. According to the analyte monitoring and automatic drug administrating system, the concentration of the analyte (such as glucose or oxygen or triglyceride or ketone bodies) can be precisely monitored through a simple device, medicine injection is carried out by the injection parts at the same time, the medicine injection area can be effectively increased, skin induration can be obviously relieved, the medicine absorption effect can be effectively enhanced, and the treatment effect is improved.

The invention discloses a handheld type multi-parameter on-site fast biochemical detector, which relates to the technology of human body detection and comprises a multi-channel detecting circuit, a work voltage generating circuit, a power circuit, a bluetooth module, a display module, a single chip microprogrammed control unit (MCU), a fixing part embedded in a single chip and various detecting strips matched with the fixing part for use. The detector can automatically identify various detecting strips to achieve the following functions: 1 simultaneous detection of three parameters of blood sugar, blood lactic acid and a blood ketone body; 2 simultaneous detection of any two of the parameters; and 3 detection of any one parameter. The detector can automatically and fast finish detection and output detection results. The bluetooth module is built in the detector and can automatically send the detection results in wireless mode. The simultaneous detection of the three parameters can effectively reduce bleeding amount and suffering of a testee. Simultaneously, the multi-parameter biochemical detector further has the advantages of automatic and fast detection, convenience in carry, long standby time, wireless data transmission and the like.

The invention discloses a reagent preparation technique which can fast test the blood ketone. The technique includes first assemble a level of metal nanometer particles on pre-processed electric pole with electrochemical deposit technique. And then fix the reaction reagent on the nanometer particle layer forming reaction layer. When blood ketone drop is dropt on the reaction layer, the basal material will reaction with the solution generate electric signals testable with electrochemistry bio sensor testing system outputting corresponding intensity signal.

An apparatus 10 for predicting change in a physical index includes an acquisition unit 13, a setting unit 12, and a calculation unit 18. The acquisition unit 13 acquires the ketone body concentration excreted by a subject. The setting unit 12 sets a set time at a present time or a later time. The calculation unit 18 calculates a predicted value of change in the physical index based on the ketone body concentration and on the set time. The predicted value of change in the physical index is the change in body weight of the subject or in the weight of body fat when the designated time elapses.

The invention relates to a method for detecting aldehyde ketone concentration in the atmosphere through combination of DNPH-silica-gel adsorption small columns and a HPLC-UV. The method comprises the following steps: (1) a sampling efficiency experiment: connecting two DNPH-silica-gel adsorption small columns in series, connecting the combined small columns with a sampling pump, and collecting an aldehyde ketone gas sample of which the concentration is known; (2) an atmosphere collection experiment: connecting a flowmeter, a potassium iodide copper pipe, the DNPH-silica-gel adsorption small columns and the sampling pump in sequence, so as to collect an aldehyde ketone gas sample in the ambient air; (3) sample treatment and analysis: slowly flushing the collected samples with acetonitrile, quantifying with a volumetric flask, and then carrying out detection through the HPLC-UV. The method has the advantages that the sampling efficiency can be 99 percent or above, the replicate analysis standard deviation of experiment data is less than 5 percent, the detection limit is as low as 0.05 to 0.15 microgram/m<3>, the detection accuracy is 3.01 to 9.65 percent, and the method is high in practicability.

Devices, patch sensors, and methods for detecting a ketone body are disclosed. An exemplary device includes a collection apparatus for collecting a sample amount of interstitial fluid and a ketone body indicator having an initial negative state and having a positive state when at least a threshold value of the ketone body is collected in the sample amount.

The invention belongs to the field of biotechnology, and particularly relates to an oligomer of (R)-3-hydroxybutyric acid and a preparation method and application of the oligomer. According to the oligomer represented by a formula I (please see the specification for the formula), n=3-10, and preferably n=3-8; and R can be H, a linear alkyl group such as methyl and ethyl, a branched alkyl group such as n-propyl and isopropyl, an aralkyl group such as benzyl and phenethyl or a metal ion such as Na, K, Ca and Mg, and more preferably ethyl. The oligomer of (R)-3-hydroxybutyric acid has the effectof increasing the level of ketone bodies in organisms, can prolong the action time and play a sustained release effect, can reduce the risks of acidosis and metal ion overload, and has the characteristics of high safety, small side effects and long action time.

The present invention relates to novel biomarkers such as histidine and ketone bodies and methods of use thereof for detecting preeclampsia in pregnant individuals and for identifying individuals at risk at an early stage of pregnancy.

The invention discloses a breath analyzer which can measure ketone body level through a noninvasive measurement method (breath analytic method) on the basis of the limitation of a ketone body level measurement method in the prior art. The breath analyzer can achieve real-time and accurate measurement on acetone concentration of human breath and directly display the blood ketone body level and reference blood glucose level. The breath analyzer also can synchronously upload data to network and displays the data on various electronic terminal devices. The breath analyzer allows diabetic patients, epileptic patients and other patients who need to measure the ketone body level and know the blood glucose level to know metabolism status themselves in real time, thereby promoting management and treatment of diseases and further significantly improving health condition and living quality.