A copper@rhubarb anthraquinone metal-organic framework composite and its application
A metal-organic framework and rhubarb anthraquinone technology, which is applied to medical preparations containing active ingredients, cosmetic preparations, pharmaceutical formulations, etc., can solve problems such as skin irritation, intradermal penetration, and phototoxicity, and achieve protection from Injuries, reduced safety issues, consistent protective effects
Active Publication Date: 2021-09-24
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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Problems solved by technology
[0002] In order to resist ultraviolet radiation, various sunscreen materials are currently launched on the market, but the sunscreen methods of these sunscreen materials are single and have certain limitations. For example, chemical sunscreens are mainly organic substances such as benzophenones and benzotriazoles. Has problems of intradermal penetration, skin irritation, phototoxicity; physical sunscreens that reflect or scatter UV radiation, with TiO 2 , ZnO and other inorganic substances, which will affect the secretion of sebaceous glands and sweat glands after use, and there are safety hazards such as inhalation
However, it has not been found that copper@rhubarb anthraquinone metal organic framework complex has anti-ultraviolet radiation, can significantly protect the skin from sunburn, and can be used as a report of sunscreen materials
Method used
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Embodiment 1
[0029] The copper@emodin metal-organic framework composite in this embodiment is made of the following raw materials in parts by mass: 1 part of emodin and 1 part of copper acetate monohydrate.
[0030] The preparation method of the copper@emodin metal-organic framework composite in this example is as follows: fully dissolve emodin and copper acetate monohydrate in N,N'-dimethylformamide respectively, and place them in a condensing reflux device at 60°C , stirred at a speed of 350rmp for 16h, collected the reaction product by centrifugation, and washed the reaction product several times with N,N'-dimethylformamide and ethanol, respectively, to obtain the copper@emodin metal-organic framework complex (Cu@ Emodin). The resulting product has the highest recovery rate and uniform particle size.
[0031] (1) Physicochemical characterization of Cu@Emodin
[0032] H NMR 1 H-NMR, X-ray powder diffraction (XRD), transmission electron microscope (TEM) and ultraviolet spectrophotomete...
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The invention discloses a copper@rhubarb anthraquinone metal organic framework compound and its application. The copper@rhubarb anthraquinone metal-organic framework compound includes the following components in parts by mass: 1-600 parts of rhubarb anthraquinone compound and 1-1200 parts of basic copper salt. The copper@rhubarb anthraquinone metal-organic framework compound of the present invention has dual functions of physical and chemical sun protection, has good anti-ultraviolet damage effect, can significantly protect the skin, and can be used as an additive for sun protection and make-up. Moreover, the copper@rhubarb anthraquinone metal-organic framework compound of the present invention is synthesized from the natural Chinese medicine component rhubarb anthraquinone compound, which reduces the safety problems caused by the penetration of general chemical sunscreen ingredients into the human body.
Description
technical field [0001] The invention relates to the technical field of sunscreen materials, in particular to a copper@rhubarb anthraquinone metal-organic framework compound and its application. Background technique [0002] In order to resist ultraviolet radiation, various sunscreen materials are currently launched on the market, but the sunscreen methods of these sunscreen materials are single and have certain limitations. For example, chemical sunscreens are mainly organic substances such as benzophenones and benzotriazoles. Has problems of intradermal penetration, skin irritation, phototoxicity; physical sunscreens that reflect or scatter UV radiation, with TiO 2 , ZnO and other inorganic substances, which will affect the secretion of sebaceous glands and sweat glands after use, and there are safety hazards such as inhalation. The development of natural traditional Chinese medicine sunscreen has better safety, and has double sunscreen and anti-oxidation properties, and h...
Claims
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IPC IPC(8): A61K8/35A61K8/19A61K8/368A61Q17/04
CPCA61K8/19A61K8/355A61K8/368A61K2800/592A61Q17/04
Inventor 肖计生苏小滢刘四军
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE