Honeysuckle vacuum freeze drying process

A vacuum freeze-drying and vacuum-drying technology, which is applied in the direction of drying solid materials, drying solid materials without heating, drying, etc., can solve the problems of water loss of plant tissue cells, no subsequent discharge, large production investment, etc., and achieve high-quality products The effect of best quality, high utilization rate and high dissolution rate

Active Publication Date: 2020-08-07
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Theoretically, the vacuum freeze-drying method has a protective effect on the easily oxidized and decomposed components in the medicinal material, and is most suitable for the initial processing of the medicinal material. However, the current domestic research results have not reflected the content analysis of the active ingredients and nutritional components of the freeze-dried samples of honeysuckle. On the one hand, the advantages of freeze-drying are due to the rapid loss of local water in plant tissue cells during the freeze-drying process, forming cell cavities, and the air in the cavities is not discharged. The enzyme is not able to continue to oxidize the active ingredients in it, resulting in the decomposition of the active ingredients in the plant tissue. The most important reason is related to the specific process requirements of freeze-drying. At present, no one has systematically carried out the research on the vacuum freeze-drying process of honeysuckle.
In addition, the price of the vacuum freeze dryer itself is high, the production investment is large, the drying time is long, and the energy consumption is large, which has caused many researchers to give up the research on the vacuum freeze-drying of honeysuckle.

Method used

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  • Honeysuckle vacuum freeze drying process
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  • Honeysuckle vacuum freeze drying process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A honeysuckle vacuum freeze-drying process, comprising the following steps:

[0029] (1) Pretreatment

[0030] (2) Arrangement, the placement thickness of honeysuckle is 1-3mm;

[0031] (3) Pre-freeze, put the honeysuckle into a vacuum freeze dryer, reduce the temperature of the honeysuckle to -30°C to -35°C, and keep it for 4-5 hours;

[0032] (4) Vacuum drying, when the temperature in the cold trap is lowered to -60°C, the vacuum degree is maintained at 20-30Pa, and the vacuum is started for sublimation drying, and the temperature is raised to 35-45°C in the drying chamber, and the vacuum degree reaches 1-10Pa After the end, the vacuum freeze-dried honeysuckle was obtained.

[0033]The specific steps of sublimation drying are as follows: the temperature of honeysuckle is maintained at -30°C to -35°C, and kept for 3.5 hours; the temperature of honeysuckle is recovered and maintained at -30 to -20°C, and kept for 2 hours; ~-10℃, keep for 2 hours; honeysuckle temperat...

Embodiment 2

[0036] Example 2 Analysis of Honeysuckle Characters by Different Drying Methods

[0037] The flowers were processed according to the conditions in Table 1, and each sample was repeated 3 times in parallel.

[0038] Table 1 Different honeysuckle drying methods

[0039]

[0040] Analysis of traits of honeysuckle by different drying methods

[0041] Table 2 Appearance traits of different dried honeysuckle

[0042]

[0043]

Embodiment 3

[0044] Method and Analysis of Organic Acid Content in Flos Lonicerae by Different Drying Methods in Example 3

[0045] (1) Chromatographic conditions

[0046] The content of the active ingredient was determined by HPLC, and the determination conditions were as follows: Chromatographic column: Agilent ZORBAX XDB-C18 (4.6mm×250mm, 5 μm); mobile phase A: 0.1% formic acid water, mobile phase B: acetonitrile; column temperature: 30°C; Injection volume: 20 μl; detection wavelength: 240nm, 325nm, 350nm; see Table 3 for mobile phase elution gradient. The number of theoretical plates calculated based on chlorogenic acid shall not be less than 5000.

[0047] Table 3 Gradient elution table of HPLC mobile phase

[0048]

[0049] (2) Preparation of reference substance solution

[0050] Accurately weigh 9.79mg of neochlorogenic acid, 10.75mg of cryptochlorogenic acid, 11.09mg of caffeic acid, 9.29mg of isochlorogenic acid B, and 4.32mg of deoxidized loganin, place them in 1ml volumetr...

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Abstract

The invention relates to the technical field of honeysuckle processing, in particular to a honeysuckle vacuum freeze-drying process which comprises the steps of: pretreatment, placement of raw materials on plates, pre-freezing and vacuum drying. According to the method, an advanced quick-freezing method is utilized, so that the vacuum freeze-drying time is shortened, the energy consumption is reduced, and substances are prevented from being continuously oxidized and decomposed under the action of enzymes in the drying process. The process for processing honeysuckle by vacuum freeze drying is researched for the first time, wherein the process parameters are optimized, so that the heat of supplied materials is minimum, the sublimated water is fastest, the drying time is shortest, the energyconsumed for removing unit mass of water is minimum, and the quality of dried products is best. Components such as organic acids, flavonoids, volatile oils, saponins and the like in the honeysuckle obtained by the method are higher than those of honeysuckle obtained by other methods, the content of chlorogenic acid is 3.19%, and the vacuum freeze drying technology has obvious advantages in the aspect of protecting poor heat sensitivity and volatile components.

Description

technical field [0001] The invention relates to the technical field of honeysuckle processing, in particular to a honeysuckle vacuum freeze-drying process. Background technique [0002] Drying can ensure that materials will not be corrupted and deteriorated, and is the most common technology in current social production. Vacuum freeze-drying refers to the method of pre-freezing the water-containing substance into a solid state, and then sublimating the water in it from a solid state to a gaseous state under a vacuum state to remove moisture and preserve the substance. This technology has incomparable advantages under conventional drying. The solid matter after freeze-drying has a porous structure and maintains the volume when it is frozen. It can be easily dissolved and restored by adding water, and can remove 95% to 99% of water. In recent years, the development of vacuum freeze-drying technology has been very rapid, especially in China, especially in the fields of food pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/355F26B5/06
CPCA61K36/355F26B5/06A61K2236/10A61K2236/17
Inventor 刘谦张喆邓志鹏蒲高斌王玲娜李佳张永清
Owner SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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