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Blood glucose and lipid lowering peptide and application thereof

A technology for lowering blood sugar, lowering fat, and diabetes, which is applied in the biological field, can solve the problems of easy side effects, drug resistance, and high price, and achieve the effect of improving antioxidant capacity, low price, and wide sources

Active Publication Date: 2020-08-07
NANJING UNIV OF FINANCE & ECONOMICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional anti-diabetic drugs are mostly chemical and biological agents with clear curative effects, but they are expensive and prone to side effects and drug resistance. Therefore, natural special dietary foods with low-cost and less side-effects that can improve diabetes have great potential for development

Method used

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  • Blood glucose and lipid lowering peptide and application thereof
  • Blood glucose and lipid lowering peptide and application thereof
  • Blood glucose and lipid lowering peptide and application thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0017] Effects of Hypoglycemic and Lipid-lowering Peptides on Diabetic Rats

[0018] 1. Diabetic Rat Modeling Method

[0019] Sixty SPF-grade healthy male SD rats, weighing 160-200g, were provided by Nanjing Qinglongshan Animal Breeding Farm. They were fed adaptively for one week, and the rats were randomly divided into 3 groups: normal control group (marked as WT), STZ-induced Model group (marked as STZ) and experimental group (marked as STZ+AOP). The normal group was fed with common feed. The remaining 40 rats were fed with high fat for 4 weeks, fasted for 16 hours, and injected with 36mg·kg -1 STZ was administered continuously for one week to establish a type II diabetes model. Fasting blood glucose was measured 3 days and 7 days after injection of STZ, respectively, and the blood glucose was higher than 12 mmol / L, which was considered as successful modeling.

[0020] Then use the small peptide of the present invention (amino acid sequence GGEDPIRW shown in SEQ ID NO: 1...

experiment example 2

[0030] Protective effect of small peptide of the present invention on abnormal proliferation of vascular smooth muscle cells

[0031] 1. MTT method to detect cell proliferation

[0032] Vascular smooth muscle cells in the logarithmic growth phase were digested with 0.05% EDTA-trypsin solution, and a certain density of cell suspension was prepared with DMEM medium containing 2% FBS, and seeded in a 96-well plate, 100 μL per well (The blank control group was added with 100 μL 2% FBS DMEM culture solution), placed at 37 ℃, 5% CO 2 After culturing in a conditioned incubator for 48 hours, the culture medium was removed, and 100 μL of low-sugar DMEM culture medium was added to each well. They were randomly divided into three groups: the normal group did not add any substances; the high glucose group (HG) added 45% glucose solution to make the final concentration 25mM; the experimental group added glucose with a final concentration of 25mM and different concentrations of the present...

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Abstract

The invention provides a blood glucose and lipid lowering peptide. The blood glucose and lipid lowering peptide has an amino acid sequence GGEDPIRW as shown in SEQ ID NO: 1. The blood glucose and lipid lowering peptide can improve the glucose tolerance of diabetic rats, enhance the blood glucose utilization capacity of the rats and remarkably reduce serum total cholesterol and serum total triglyceride, and has antioxidant activity; and thus the blood glucose and lipid lowering peptide has the great development prospects in the aspects of preventing atherosclerosis and other complications in ahigh-glucose environment and the like.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a small peptide and its application. Background technique [0002] Diabetes mellitus is a systemic metabolic disease characterized by relative or absolute insufficiency of insulin and hyperglycemia as the main symptom. Insufficient insulin secretion or related function blockages lead to elevated blood sugar, leading to metabolic disorders of the body, eventually affecting normal physiological functions and causing complications. diseases such as atherosclerosis. Common diabetes is divided into type 1 diabetes and type 2 diabetes. Traditional antidiabetic drugs are mostly chemical and biological agents with clear curative effects, but they are expensive and prone to side effects and drug resistance. Therefore, natural special dietary foods with low price and less side effects that have diabetes-improving activity have great potential for development. It is urgent to deve...

Claims

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Application Information

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IPC IPC(8): C07K14/415A61K38/16A61P3/10A61P3/06A61P9/10A61P39/06A23L33/18
CPCC07K14/415A61P3/10A61P3/06A61P9/10A61P39/06A23L33/18A61K38/00A23V2002/00A23V2200/328A23V2200/3262A23V2200/326A23V2200/302
Inventor 汪芳李玉珍沈新春
Owner NANJING UNIV OF FINANCE & ECONOMICS
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