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Biosensor combining terahertz metamaterial and microfluid technology and application of biosensor in detection of liquid-phase biological sample

A biosensor and metamaterial technology, which is applied to biosensors and application fields in liquid-phase biological sample detection, can solve the problems such as the need for breakthrough in detection sensitivity, and achieve fast analysis speed, high application prospects, and low consumption of samples and reagents. Effect

Pending Publication Date: 2020-08-07
THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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Problems solved by technology

[0005] 1) THz wave detection sensitivity: The sensitive characteristics of THz wave technology, such as detection speed, signal-to-noise ratio, and detection depth, need to be further improved in terms of light source and detection and reception. The detection sensitivity of trace or low-concentration biological samples still needs to be broken through

Method used

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  • Biosensor combining terahertz metamaterial and microfluid technology and application of biosensor in detection of liquid-phase biological sample
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  • Biosensor combining terahertz metamaterial and microfluid technology and application of biosensor in detection of liquid-phase biological sample

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Embodiment

[0030] The first step: making a terahertz metamaterial biosensing chip

[0031] Deposit a micro-processed gold film SRRs array on a silicon substrate, specific parameters: 1. Substrate silicon wafer material: thickness 500μm, unit area 15mm*15mm; 2. Gold film SRRs array: SRR: thickness 120nm, structure inner diameter 48μm, outer The diameter is 60 μm, the double opening is circular, the opening gap (G) is 3 μm wide, and the double opening angle (θ) is 120 degrees; SRRs array: the distance between the centers of the circles is 90 μm, and the array area is 5*5mm.

[0032] Step 2: Making PDMS Microfluidic Channels

[0033] First, a microfluidic channel mold was prepared on a silicon substrate by SU-8 photoresist lithography process, with a thickness of 50 μm; secondly, a PDMS microfluidic channel was fabricated according to the mold.

[0034] Step Three: Assembling the Micropipes

[0035] Assemble stainless steel and transparent plastic micropipes onto PDMS (micropipe inner dia...

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Abstract

The invention relates to a biosensor combining a terahertz metamaterial and a microfluid technology and the application of the biosensor in detection of a liquid-phase biological sample. A terahertz microfluid biosensor chip is manufactured by integrating the microfluid technology on the basis of the terahertz metamaterial biosensor chip, the chip has the characteristics of controllable liquid flow, less sample and reagent consumption and high analysis speed, and the sample introduction and the sample replacement integrated cycle operation can be carried out in a sample detection pool. The micro-fluid technology is adopted to control a micro-sample to enter a micro-channel, by combining the high sensitivity of the terahertz metamaterial, the water sensitivity of terahertz waves is overcome, the label-free, rapid and high-sensitivity detection of the biological sample in a liquid phase state is achieved, and the biological sample can be recycled, so that the method and the device combining the terahertz metamaterial and the microfluid technology can be developed into a novel terahertz biosensing technology for the high-sensitivity and automatic detection of the liquid-phase biological sample, and have the higher application prospect.

Description

technical field [0001] The invention belongs to the technical field of biological detection, and relates to a biosensor combined with a terahertz metamaterial and a microfluidic technology and its application in liquid phase biological sample detection. Background technique [0002] Terahertz radiation (THz) waves are located between microwaves and infrared rays in the electromagnetic spectrum, with a frequency range of 0.1THz to 10THz (1THz=1012Hz, or 1THz=4.14meV photon energy), and a wavelength range of 30μm to 3mm. THz wave technology combines the characteristics of electronics and photonics, and is a typical interdisciplinary subject. New means of any chemical and biological labeling. [0003] At present, the research hotspots of THz wave technology in the field of biomedicine mainly focus on the detection and identification of bioorganic molecules, cells or tissues. , molecular vibration, molecular rotation, etc.) spectrum falls in the terahertz band, by analyzing an...

Claims

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Application Information

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IPC IPC(8): G01N21/3581B01L3/00
CPCG01N21/3581B01L3/5027B01L2200/10
Inventor 张阳李育敏府伟灵张秀明
Owner THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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