Traditional Chinese medicine compound preparation for treating subacute thyroiditis in acute stage and preparation method of traditional Chinese medicine compound preparation

A technology for thyroiditis and compound preparations, applied in anti-inflammatory agents, pharmaceutical formulas, non-central analgesics, etc., can solve the problems of syndrome differentiation, classification, and treatment of subacute thyroiditis that have not yet been formed, and achieve fewer adverse reactions, The effect of definite curative effect and convenient use

Active Publication Date: 2020-08-25
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The understanding of this disease has a long history. Many doctors have put forward many opinions on this disease and achieved good curative effect in clinical observation, which proves that the treatment of traditional Chinese medicine is the unique advantage of subacute thyroiditis. However, the syndrome differentiation and staging of subacute thyroiditis has not yet been formed Unified consensus on classification, classification and treatment

Method used

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  • Traditional Chinese medicine compound preparation for treating subacute thyroiditis in acute stage and preparation method of traditional Chinese medicine compound preparation
  • Traditional Chinese medicine compound preparation for treating subacute thyroiditis in acute stage and preparation method of traditional Chinese medicine compound preparation
  • Traditional Chinese medicine compound preparation for treating subacute thyroiditis in acute stage and preparation method of traditional Chinese medicine compound preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 A traditional Chinese medicine compound preparation for treating subacute thyroiditis in the acute phase and its preparation method.

[0044] A traditional Chinese medicine compound preparation for treating subacute thyroiditis, which is made of the following raw materials in parts by weight: 15 parts of Cimicifuga, 15 parts of Bupleurum, 12 parts of silkworm, 9 parts of mint, 15 parts of Coptidis, wine 15 parts of skullcap, 15 parts of burdock, 12 parts of raw licorice, 15 parts of bellflower, 15 parts of isatidis, 15 parts of forsythia, 15 parts of scrophulariaceae, 12 parts of cicada slough, and 12 parts of turmeric.

[0045] The preparation method of the traditional Chinese medicine compound preparation for treating the acute phase of subacute thyroiditis specifically includes the following steps. Step 1: Weigh Coptis chinensis, wine skullcap, burdock fruit, raw licorice, bellflower, isatidis, forsythia, crocodile, cicada slough, and turmeric in parts by w...

Embodiment 2

[0054] Example 2 Study on the pharmacological action mechanism of traditional Chinese medicine compound preparations for the treatment of subacute thyroiditis in the acute phase—an in vitro research experiment of interfering with the pyroptosis process of thyroid follicular epithelial Nthy-roi3-1 cells infected by adenovirus.

[0055] 1. Experimental materials.

[0056] 1.1 Main reagents.

[0057] Nthy-roi3-1, Shanghai Fuheng Biotechnology Co., Ltd.; adenovirus, Weizhen Bio; 1640 medium, Hycone Company; PBS, Hycone Company; fetal bovine serum, GIBCO Company; CytoTox Non-Radioactive Cytotoxicity Assay kit, Promega; Human Interleukin-1β ELISA Kit, Solarbio; Human Interleukin-18 ELISA Kit, Solarbio; PMSF, Beyotime; Protein Extraction Reagent (improved RIPA formula), Beyotime; Ponceau Staining solution, Beyotime; BCA protein concentration determination kit P0012, Beyotime; ultra-sensitive ECL chemiluminescence kit P0018, Beyotime.

[0058] Table 1. Quantitative Real-time PCR pr...

Embodiment 3

[0134] Example 3 clinical data.

[0135] In order to further verify the beneficial effects of the present invention, the following test cases are provided.

[0136] 1. Observation on the clinical curative effect of traditional Chinese medicine compound in treating patients with subacute thyroiditis with syndrome of flaming heat and toxin in the acute stage.

[0137] 1. Clinical data.

[0138] 1.1 General Information.

[0139] 62 patients came from newly diagnosed untreated patients with acute SAT (flashing heat and toxin syndrome) who visited the Endocrinology Department of the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from January 2017 to December 2019. All patients were randomly divided according to the random number table. It is the traditional Chinese medicine group and the prednisone (western medicine) group, with 31 cases in each group. During the test period, 1 sample was lost in the two groups, and a total of 60 cases were included in...

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Abstract

The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine compound preparation for treating subacute thyroiditis in anacute stage and a preparation method of the traditional Chinese medicine compound preparation. The traditional Chinese medicine compound preparation is prepared from the following raw material medicines in parts by weight: 15-30 parts of rhizoma cimicifugae, 15-30 parts of radix bupleuri, 12-15 parts of bombyx batryticatus, 9-15 parts of mint, 6-20 parts of coptis chinensis, 9-20 parts of radix scutellariae (processed with wine), 15-20 parts of fructus arctii, 12-15 parts of radix glycyrrhizae, 10-25 parts of platycodon grandiflorum, 10-20 parts of radix isatidis, 10-20 parts of fructus forsythiae, 15-25 parts of radix scrophulariae, 9-15 parts of periostracum cicadae and 9-15 parts of rhizoma curcumae longae. The traditional Chinese medicine compound preparation is based on a traditionalChinese medicine academic thought formula of dissipating excessive stagnation of fire principle, a main treatment method of invigorating YANG and clearing away heat is achieved, the whole preparationhas effects of dissipating excessive stagnation of fire principle, clearing away heat toxin, regulating pivot, combining dissipation and clearing, and achieving downbearing within upbearing, so thatthe thyroid pain symptom of subacute thyroiditis is rapidly relieved, the pain time is shortened, and the thyroid enlargement degree is relieved. The traditional Chinese medicine compound preparationis definite in treatment effect and few in adverse reaction, an effect of treating both symptoms and root causes can be achieved, and the preparation method of the traditional Chinese medicine compound preparation is suitable for industrial production and convenient to develop and apply.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, relates to the field of treating endocrine diseases with internal treatment technology of traditional Chinese medicine, in particular to a compound Chinese medicine preparation for treating acute subacute thyroiditis and a preparation method thereof. Background technique [0002] Subacute thyroiditis is the most common disease causing thyroid pain, accounting for 0.5% to 6.2% of all thyroid diseases. Inflammation in the acute stage of the disease leads to severe metastatic pain in the thyroid gland, fever and changes in thyroid function seriously affect the patient's life, study and work. [0003] At present, the first-choice drugs for the treatment of acute stage are glucocorticoids and non-steroidal antipyretic and analgesic drugs. The course of treatment is as long as 6 to 8 weeks. The side effects of drugs often lead to the occurrence of peptic ulcer, abnormal glucose ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P5/14A61P29/00A61P1/14A61P39/00A61K35/64
CPCA61K36/71A61K36/233A61K35/64A61K36/534A61K36/718A61K36/539A61K36/28A61K36/484A61K36/346A61K36/195A61K36/315A61K36/634A61K36/808A61K36/9066A61P5/14A61P29/00A61P1/14A61P39/00A61K2236/331A61K2236/39A61K2300/00
Inventor 高天舒
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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