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Extraction method of chlorogenic acid

An extraction method and technology of chlorogenic acid, which are applied in coffee extraction, separation/purification of carboxylate, function of food components, etc., can solve the problem of unclear Hb1Ac reduction effect, inability to effectively obtain yield chlorogenic acid, long-term The problem of low compliance with food consumption can prevent diabetes-related nephropathy, improve sensitivity, and have no toxic and side effects.

Active Publication Date: 2020-08-28
GUANGZHOU NARNIA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first category of products will naturally reduce the rise in blood sugar because they eat foods with a low glycemic index. However, for patients who eat three meals a day for a long time, it is difficult to stick to one or a few products, and they have to give up.
The second category of products is more mixed, the mechanism is not clear, the compliance of long-term consumption is low, and the effect of reducing Hb1Ac is not clear, etc.
[0009] Chlorogenic acid has a wide range of sources, but the extraction efficiency of chlorogenic acid in the prior art is not high. Although a large amount of raw materials are used, chlorogenic acid with higher yield or higher purity cannot be effectively obtained.

Method used

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  • Extraction method of chlorogenic acid
  • Extraction method of chlorogenic acid
  • Extraction method of chlorogenic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] A method for extracting chlorogenic acid, comprising the following steps:

[0064] (1) Take green coffee beans, pulverize them, dry them at 40°C, and pass through an 80-mesh sieve to obtain coffee powder;

[0065] (2) Take coffee powder and add extraction solvent ethanol, carry out ultrasonic treatment, ultrasonic power is 160W, ultrasonic temperature is 40 ℃; The time of ultrasonic is 20min; Obtain extract liquid and residue;

[0066] (3) Add twice as much water to the extract, heat to 40°C, add calcium chloride, stir and separate layers, discard the solution layer, and obtain calcium salt of chlorogenic acid;

[0067] (4) suspending the calcium salt of chlorogenic acid in ethanol, adding carbonic acid solution to adjust the pH value to 4.5, generating an ethanol aqueous solution layer and a precipitate layer, filtering to obtain an ethanol aqueous solution layer;

[0068] (5) The aqueous ethanol layer is heated to 50°C, and passes through a mixture of coconut shell a...

Embodiment 2

[0070] (1) A method for extracting chlorogenic acid, comprising the steps of: taking green coffee beans, pulverizing them, drying them at 50°C, and passing through a 120-mesh sieve to obtain coffee powder;

[0071] (2) Take coffee powder and add extraction solvent ethanol, carry out ultrasonic treatment, power is 180W, ultrasonic temperature is 60 ℃; The time of ultrasonic is 40min; Obtain extract liquid and residue;

[0072] (3) Add 3 times of water to the extract, heat to 60°C, add calcium chloride, stir and separate layers, discard the solution layer, and obtain calcium salt of chlorogenic acid;

[0073] (4) suspending the calcium salt of chlorogenic acid in ethanol, adding carbonic acid solution to adjust the pH value to 5.5, generating an ethanol aqueous solution layer and a precipitate layer, filtering to obtain an ethanol aqueous solution layer;

[0074] (5) The ethanol aqueous solution layer is heated to 60 ℃, through the mixture of coconut shell activated carbon and a...

Embodiment 3

[0076] A fermented soybean solid beverage with hypoglycemic effect consists of the following raw materials in parts by weight:

[0077]

[0078]

[0079] Preparation method: Mix all the materials evenly, pack into a 10g / bag of fermented soybean solid drink.

[0080] Dissolve in 100-150mL warm water and eat after fully dissolving. It is recommended to take it before meals every day, 1 packet each time, once a day.

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Abstract

The invention belongs to the technical field of chlorogenic acid preparation, and particularly relates to an extraction method and application of chlorogenic acid. The chlorogenic acid with higher yield and purity is prepared through the extraction steps of green coffee bean extraction, separation, activated carbon purification and the like, the extraction method can effectively improve the extraction efficiency of the chlorogenic acid, and the chlorogenic acid has better effects of reducing blood sugar and blood fat; and the chlorogenic acid can be well applied to products for treating hypertension.

Description

technical field [0001] The technical field of the preparation of chlorogenic acid of the present invention specifically relates to a method for extracting chlorogenic acid. Background technique [0002] The harm of diabetes to the human body is mainly manifested in complications. If diabetes is not well controlled, it will cause chronic damage and dysfunction of the brain, heart, nerves, eyes, kidneys, and nerves, and even lead to disability or death. [0003] For patients with type 2 diabetes, there are generally only two ways to control the disease, drug treatment or weight loss surgery. Drug treatment for diabetes includes oral hypoglycemic drugs and insulin injections. Drugs can be divided into three categories according to different mechanisms of action: stimulating insulin secretion (sulfonylureas and non-sulfonylureas), increasing insulin sensitivity (biguanides, thiazolidinediones), and inhibiting sugar absorption (α-glycosides). enzyme inhibitors). [0004] Ther...

Claims

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Application Information

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IPC IPC(8): C07C67/48C07C69/732A21D13/06A23F5/38A23F5/40A23L11/00A23L27/00A23L27/10A23L27/24A23L33/00A23L33/105A23L33/14A23L11/50
CPCC07C67/48A23F5/385A23F5/40A23L33/105A23L33/14A23L33/00A23L27/00A23L27/24A23L27/11A23L27/10A21D13/06C07C2601/14A23V2002/00A23L11/50C07C69/732A23V2250/028A23V2250/2108A23V2200/328
Inventor 刘小青郑政东
Owner GUANGZHOU NARNIA BIOTECH CO LTD
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