The invention belongs to the field of lubricating oils, particularly relates to a fully synthetic ester-based gasoline-injection engine lubricating oil. The lubricating oil is prepared from the following raw materials: PAO4, PAO6, PAO8, metallocene PAO (Poly Alpha Olefins), diester A41, diester A51, polyalcohol ester NP451, polyalcohol ester NP343, alkyl naphthalene, a compound gasoline-injection engine oil additive, a hydrolysis inhibitor and an antioxidant enhancement package, wherein the proportion of the V-type ester-based base oil exceeds 30%, so that the lubricating oil is strong in anti-shearing capacity, namely, the lubricating oil is a fully synthetic high-performance ester-based lubricating oil which can be safely used for a long period. The invention further provides a preparation process of the fully synthetic ester-based gasoline-injection engine lubricating oil. The preparation process is reasonable. Thus, the evaporation loss of a finished product of the lubricating oil is minimized; and the high-temperature of the lubricating oil is performed before the lubricating oil is injected into an engine, so that the synergistic effects of all components of the lubricating oil are exerted well.