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Stable fluorescent particle and preparation method thereof

A fluorescent particle, stable technology, applied in the field of stable fluorescent particle and its preparation, can solve the problem of low coating rate, achieve the effect of improving fluorescence intensity, stable optical performance, and increasing stability

Inactive Publication Date: 2020-08-28
CHONGQING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the coating rate is not high in the current coating method

Method used

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  • Stable fluorescent particle and preparation method thereof
  • Stable fluorescent particle and preparation method thereof
  • Stable fluorescent particle and preparation method thereof

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Experimental program
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Embodiment

[0026] (1) Add 6mL, 25mM reduced glutathione to 4mL, 25mM chloroauric acid solution, mix with 40mL ultrapure water, and add to a round bottom flask. Stir vigorously at room temperature until the solution becomes colorless, then raise the temperature to 70°C and stir slowly for 24 h. The collected samples were dialyzed for 3 days to obtain nanoparticles of about 2nm. Electron microscope observation showed that figure 1 shown.

[0027] (2) Put 3 mL of nanoparticles into a flask, add 20 mL of ethanol and 1 mL of ammonia water mixture, 1 mL of TEOS, and 5 mL of ethanol, and stir for 4 hours to obtain fluorescent particles. Electron microscope observation results such as figure 2 shown.

[0028] (3) Put 3 mL of nanoparticles into a flask, add 100 μL of APTES and stir for 1 h. Then add 20mL of ethanol and 1mL of ammonia water mixture, 1mL of TEOS, 5mL of ethanol, and stir for 4h.

[0029] Such as figure 1 , figure 2 As shown, the particle size of the gold nanoparticles obt...

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Abstract

The invention discloses a stable fluorescent particle and a preparation method thereof. The preparation method comprises the following steps: reacting reduced glutathione with noble metal ions in an aqueous solution to obtain particles with the diameter of 1-20 nm; adding organosilane with an amino group into the obtained aqueous dispersion of the particles, and stirring for reaction to obtain a mixed solution; and adding ethanol and ammonia water into the mixed solution to obtain a micro-emulsion, then adding tetraethoxysilane and ethanol into the micro-emulsion, and stirring for reaction toobtain the stable fluorescent particle. The coating efficiency of the method is close to 100%, the utilization rate of raw materials is greatly increased, and material waste is avoided. Meanwhile, thestability of the obtained fluorescent particle is improved, and the fluorescence intensity of the fluorescent particle is improved.

Description

technical field [0001] The invention relates to noble metal fluorescent materials, in particular to a stable fluorescent particle and a preparation method thereof. Background technique [0002] As a material that has attracted much attention in recent years, metal nanoparticles have the advantages of good fluorescence properties, good optical stability, good biocompatibility and low toxicity. Metal nanoparticles synthesized with different materials will have different emission wavelengths of fluorescence, and different functional groups make them have the potential for further modification and application. Therefore, the advantages of metal nanoparticles make their applications in the fields of bioimaging, biochemical sensors, and cancer diagnosis and treatment gradually attract people's attention. However, the relatively low fluorescence quantum yield, high chemical activity, and unstable performance in solution of metal nanoparticles greatly limit their applications. The...

Claims

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Application Information

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IPC IPC(8): C09K11/02C09K11/58C09K11/87B82Y30/00B82Y40/00
CPCB82Y30/00B82Y40/00C09K11/025C09K11/58C09K11/87
Inventor 刘玉菲安佳陈美珠袁梦迪崔洪源
Owner CHONGQING UNIV
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