Absorbable zinc-based alloy drug-loaded stent

Abstract

The invention provides an absorbable zinc-based alloy drug-loaded stent, which is a net pipe type stent and is composed of a plurality of supporting units and connecting rods, and a drug-loaded coating for carrying drugs is arranged on the surface of the absorbable zinc-based alloy drug-loaded stent. The supporting units at the two ends of the absorbable zinc-based alloy drug-loaded stent are composed of a plurality of n-shaped corolla arc-shaped wave units, and the supporting units in the middle of the absorbable zinc-based alloy drug-loaded stent are composed of a plurality of n-shaped corolla arc-shaped wave units and m-shaped corolla arc-shaped wave units. The prepared stent can overcome the defect that the degradation rate is not matched with vascular reconstruction due to excellent corrosion resistance of a zinc alloy serving as a matrix material; the drug-loaded structure can control drug release, inhibit intimal hyperplasia and effectively treat diseased blood vessels; and dueto the special structural design, the stent has a good mechanical property, expansibility and flexibility.

Description

Technical field [0001] The invention relates to the field of medical devices, and particularly relates to an absorbable zinc-based alloy drug-carrying stent. Background technique [0002] Since the world’s first percutaneous transluminal coronary angioplasty was completed by Professor Gruentzing in 1977, percutaneous coronary intervention has begun to develop rapidly. For more than forty years, it has experienced the era of balloon expansion and bare metal stent. And the era of drug-eluting stents. Among them, the metal stent is permanently stored in the body as a "foreign body" during the application process, which stimulates the self-rejection reaction in the human body. Complications such as advanced stent internal thrombosis can lead to stent restenosis, which has become the main reason affecting the clinical effect. With the development of materials science, a new treatment concept came into being. The use of absorbable materials to make stents can effectively support the d...

AI Technical Summary

Problems solved by technology

[0007] The invention provides an absorbable zinc-based alloy drug-loaded stent, the purpose of which is to overcome the adverse consequences caused by the permanent storage of the traditional non-absorbable metal stent in the body, and to avoid the poor mechanical properties and degradation of the absorbable polymer stent The acidity of the product stimulates inflammation and other deficiencies

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