Reagent kit for detecting lymphoma genovariation and application of reagent kit

A gene mutation and lymphoma technology, applied in the detection kit for lymphoma gene mutation, lymphoma gene mutation detection and DLBCL cell origin typing, can solve the problems of inability to accurately identify DLBCL, inconsistency, poor reproducibility, etc.
CN111662983AActive Publication Date: 2020-09-15BEIJING GENEPLUS TECH +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING GENEPLUS TECH
Publication Date
2020-09-15

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Abstract

The invention discloses a reagent kit for detecting lymphoma genovariation and an application of the reagent kit, and particularly discloses the reagent kit for detection or auxiliary detection of variation of a lymphoma related gene. The reagent kit comprises a substance for detecting BCL2,BCL6, MYC and / or gene IGH fusion, the substance is a complete set of DNA probes, and the complete set of theDNA probes comprises 376 probes as shown in SEQID NO:1 to SEQ ID NO:376. The reagent kit can be used for detection or auxiliary detection of the variation of the lymphoma related gene, substyping ofcells of origin (cell of origin, COO) of patients suffering from diffuse large B-cell lymphoma, and auxiliary diagnosis, prognostication judging and / or targeted drug prediction of the patients suffering from lymphoma.
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Description

technical field

[0001] The invention relates to the field of biotechnology, in particular to a kit for detecting lymphoma gene variation. It particularly relates to the detection of lymphoma gene variation and the origin typing of DLBCL cells by using the kit. Background technique

[0002] Lymphoma is a malignant tumor originating from the lymphatic hematopoietic system, ranking the eighth among common malignant tumors. In recent years, lymphoma has become the fastest-growing malignant hematological tumor in my country. There are many kinds of them, and their morphology, biological behavior and clinicopathological features are heterogeneous, which has caused great troubles to the diagnosis and treatment of pathologists and clinicians.

[0003] Diffuse large B-cell lymphoma (DLBCL) is a malignant tumor originating from B lymphocytes and is the most common non-Hodgkin's lymphoma. In my country, DLBCL accounts for about 40% of all non-Hodgkin's lymphoma [Yang, Q.P., Zhang, W...

Claims

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