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Volatile-oil-substance micro-nano-drug delivery system, preparation method therefor and application of volatile-oil-substance micro-nano-drug delivery system

A delivery system and micro-nano technology, applied in the field of natural product pharmacy and engineering, can solve the problems that volatile oil nano-products cannot have the unique advantages of nano-drugs, it is difficult to effectively construct functional nano-drugs, and the components of volatile oils are easy to change, etc., to achieve functional Intact properties, non-destructive integrity, no solvent residue effect

Inactive Publication Date: 2020-09-29
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, the traditional method for preparing solid nanoparticles of volatile oil is mainly high-pressure homogenization-spray drying method. Due to repeated operations and high temperature, the components of volatile oil are very easy to change, and the medicinal value is lost or reduced. The problem of easy volatilization and loss of volatile oil in the process
[0010] In general, there are still many problems in the traditional nanotechnology of volatile oil of traditional Chinese medicine. The prepared nano-products of volatile oil cannot fully reflect the unique advantages that nano-medicines should have. drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] (1) Supercritical penetration stage:

[0038] First, put 200mg of MCM-41 mesoporous silicon with a diameter of about 80nm into the autoclave and seal it, inject 2mL of patchouli oil through nozzle 1, and then inject CO through nozzle 2. 2 Make the pressure reach 15MPa, and at the same time raise the temperature to 40°C, start the process of infiltrating the patchouli oil in the supercritical state into the mesoporous silicon for 1 hour, and the duration is 1 hour;

[0039] (2) Volatile oil loading stage:

[0040] After the system reaches equilibrium in the above steps, the temperature of the system is lowered to 25°C through the condensate water system of the kettle body, so that the system is out of the supercritical state, and then the CO is slowly discharged. 2 Perform pressure relief, the pressure relief time is 15 to 25 minutes, so that patchouli oil is loaded in MCM-41 mesoporous silicon, and CO is recovered at the same time 2 and unloaded patchouli oil;

[004...

Embodiment 2

[0044] (1) Supercritical penetration stage:

[0045] First, 200 mg of chitosan-modified mesoporous silicon (CS-MSN) with a diameter of about 85 nm was put into the autoclave and sealed, and 2 mL of cinnamon oil was injected through nozzle 1, and then CO was injected through nozzle 2. 2Make the pressure reach 18MPa, and at the same time raise the temperature to 42°C, and start the process of cinnamon oil in the supercritical state permeating and loading the CS-MSN nanocarrier, and the duration is 1.5h;

[0046] The carrier CS-MSN used is a self-made carrier. For the method, see X.Hu, Y.Wang, B.Peng, Chitosan-capped mesoporous silica nanoparticles as pH responsive nanocarriers for controlleddrug release, Chem.Asian J.9(1)(2014)319– 327

[0047] (2) Volatile oil loading stage:

[0048] After the system reaches equilibrium in the above steps, the temperature of the system is lowered to 20°C through the condensate water system of the kettle body, so that the system is out of the ...

Embodiment 3

[0052] (1) Supercritical penetration stage:

[0053] First put 200 mg of silk protein nano-aerosol particles (SFN) with a diameter of about 170 nm into the autoclave and seal it, inject 2 mL of zedoary oil through nozzle 1, and then pass into CO through nozzle 2. 2 Make the pressure reach 16MPa, and at the same time raise the temperature to 40°C, start the process of zedoary oil in the supercritical state permeating into the SFN nano-carrier, and the duration is 1.5h;

[0054] The carrier SFN used is a self-made carrier, and the preparation method is shown in L.Goimil, V.Santos-Rosales, A.Delgado, C. R. Reyes, A.A. Lozano-Pérez, S.D. Aznar-Cervantes, J.L. Cenis, J.L. Gómez-Amoza, A. Concheiro, C. Alvarez-Lorenzo, C.A. García-González, ScCO2-foamed silkfibroin aerogel / poly(∈-caprolactone) scaffolds containing dexamethasone forbone regeneration. J CO2 UTIL 31(2019) 51-64.

[0055] (2) Volatile oil loading stage:

[0056] After the system reaches equilibrium in the above step...

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Abstract

The invention belongs to the technical fields of natural product pharmacy and engineering technologies and particularly discloses a volatile-oil-substance micro-nano-drug delivery system, a preparation method therefor and application of the volatile-oil-substance micro-nano-drug delivery system. The method specifically comprises the steps: uniformly mixing a porous / mesoporous micro-nano-carrier and a volatile oil substance, then, introducing CO2, carrying out heating-up, and starting an infiltration loading process of the volatile oil substance in a supercritical state; after the infiltrationloading process of the volatile oil substance in the supercritical state reaches balance, enabling a system to be divorced from the supercritical state through cooling and pressure relief, and loadingthe volatile oil substance into the porous / mesoporous micro-nano-carrier; and repeating this process, and then, carrying out collecting, thereby obtaining volatile-oil-substance-loaded micro-nano particles. By utilizing unique advantages of supercritical CO2 that the supercritical CO2 is environmentally friendly and is ultrahigh in infiltration, the prepared high-load-dosage volatile-oil-substance micro-nano-drug powder is solid powder, and the load dosage is higher than 30% (wt%).

Description

technical field [0001] The invention belongs to the technical field of natural product pharmacy and engineering technology, and in particular relates to a volatile oil substance micro-nano drug delivery system and its preparation method and application. Background technique [0002] Essential oil is one of the important component categories in traditional Chinese medicine. It is a kind of oily liquid that is volatile, highly fat-soluble, insoluble in water, has aroma or pungent smell, and plays an important therapeutic role in traditional Chinese medicine. . Modern pharmaceutical research has proved that the volatile oil of traditional Chinese medicine has various functions such as antibacterial, anti-inflammatory, anti-allergic, anti-tumor, and anthelmintic. [0003] However, the volatile oil is extremely unstable, volatile, and easily oxidized and decomposed to lose or reduce the pharmacological effect, which brings great difficulties to the medicinal use of the volatile ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/532A61K36/54A61K36/9066A61K9/14A61K47/36A61K47/42A61K47/04A61J3/00
CPCA61K36/532A61K36/54A61K36/9066A61K9/146A61K9/143A61J3/00
Inventor 贾竞夫周雪葛发欢
Owner SUN YAT SEN UNIV
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