Novel compound and pharmaceutically acceptable salt thereof

A compound and pharmaceutical technology, applied in organic chemistry, drug combination, anti-tumor drugs, etc., can solve the problems of brain cancer treatment effect to be improved, limited anti-cancer effect, etc.
CN111718352AActive Publication Date: 2020-09-29HANGZHOU PUSH KANG BIOTECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HANGZHOU PUSH KANG BIOTECH CO LTD
Publication Date
2020-09-29

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Abstract

The invention discloses a compound or a pharmaceutically acceptable salt thereof. The compound includes a moiety derived from temozolomide and a moiety derived from elemene, and the moiety derived from temozolomide and the moiety derived from elemene are directly covalently linked or covalently linked via a linker. The invention also discloses a composition comprising the above compound, and a method of treating cancers.
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Description

technical field

[0001] The present invention relates to the field of medicinal chemistry, in particular to a novel compound or a pharmaceutically acceptable salt thereof, wherein the compound includes a part derived from temozolomide and a part derived from elemene. Background technique

[0002] Elemene belongs to the sesquiterpenes. It is a natural medicine with clear anticancer activity extracted from the rhizome of Zingiberaceae Wenyujin (Ezhu) in China. It is a new type of anticancer drug. Elemene is mainly β-elemene, with a small amount of α-elemene, γ-elemene and δ-elemene. Elemene is a kind of volatile oil, so it has strong volatility and fat solubility. It is mainly used clinically for various cancers such as esophageal cancer, lung cancer, brain tumor, liver cancer, cervical cancer, cancerous chest, and cancer-related diseases. Symptoms (such as ascites). Among them, β-elemene is the main anti-cancer substance, and also has the functions of relieving cancer pain, ...

Claims

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