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Magnetic acoustic contrast agent composition, magnetic acoustic contrast agent, magnetic microvesicle acoustic contrast agent and preparation method of magnetic acoustic contrast agent

A technology of ultrasound contrast agent and composition, which is applied in the field of biomedicine, can solve the problems of poor stability of magnetic microbubble contrast agents, achieve high stability, and achieve the effect of local high-concentration targeted delivery

Active Publication Date: 2020-10-02
NANJING TRANSCEND VIVOSCOPE BIO TECH CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to overcome the problem of poor stability of the existing magnetic microbubble contrast agent, and provide a magnetic ultrasonic contrast agent composition, a magnetic ultrasonic contrast agent containing the magnetic ultrasonic contrast agent composition, and a magnetic microbubble ultrasonic contrast agent composition. Preparation method of agent and magnetic microbubble ultrasonic contrast agent obtained therefrom

Method used

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  • Magnetic acoustic contrast agent composition, magnetic acoustic contrast agent, magnetic microvesicle acoustic contrast agent and preparation method of magnetic acoustic contrast agent
  • Magnetic acoustic contrast agent composition, magnetic acoustic contrast agent, magnetic microvesicle acoustic contrast agent and preparation method of magnetic acoustic contrast agent
  • Magnetic acoustic contrast agent composition, magnetic acoustic contrast agent, magnetic microvesicle acoustic contrast agent and preparation method of magnetic acoustic contrast agent

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preparation example 1

[0063] (a) Mix triethylene glycol and iron acetylacetonate in a molar ratio of 3:1. Heating at a high temperature of 280°C for 1h, the superparamagnetic Fe 3 o 4 Nanoparticles, and use a transmission electron microscope to observe a particle size of 7-10nm;

[0064] (b) magnetically purifying the superparamagnetic nanoparticles;

[0065] (c) Mix the superparamagnetic nanoparticles obtained in step (b) with the aqueous solution of surfactant B agent (sodium citrate solution) at a molar ratio of 1:1.5, vibrate for 15 min under ultrasonic conditions of 300 kW, and repeat 3 times;

[0066] Obtaining superparamagnetic Fe surface-modified with sodium citrate 3 o 4 nanoparticles.

preparation example 2

[0068] Refer to the method of Preparation Example 1, except that the amount of sodium citrate is changed so that the molar ratio of superparamagnetic nanoparticles to surfactant B is 1:1.8.

preparation example 3

[0070] Refer to the method of Preparation Example 1, except that the amount of sodium citrate is changed so that the molar ratio of superparamagnetic nanoparticles to surfactant B is 1:1.2.

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Abstract

The invention relates to the field of biomedicines, in particular to a magnetic acoustic contrast agent composition, a magnetic acoustic contrast agent, a magnetic microvesicle acoustic contrast agentand a preparation method of the magnetic acoustic contrast agent. The magnetic acoustic contrast agent composition comprises lipid, a surfactant and magnetic nanometer particles, wherein the surfactant consists of a surfactant A and a surfactant B; the surfactant A is in the free state, the surfactant B is in combined state to be modified on the surfaces of the magnetic nanometer particles; and the HLB value of the surfactant A is 8. Compared with the lipid of 1mol, the content of the surfactant A is 0.1-1mol, the content of the surfactant B is 0.1-1mol, and the content of the magnetic nanometer particles is 0.05-0.5mol. The magnetic microvesicle acoustic contrast agent prepared from the magnetic acoustic contrast agent composition has high stability, can meet in vivo circulation targeting delivery requirements, and realizes local high-concentration targeting delivery of medicines.

Description

technical field [0001] The present invention relates to the field of biomedicine, in particular to a magnetic ultrasonic contrast agent composition, a magnetic ultrasonic contrast agent containing the magnetic ultrasonic contrast agent composition, a preparation method of a magnetic microbubble ultrasonic contrast agent and a magnetic microbubble ultrasonic contrast agent obtained therefrom agent. Background technique [0002] At present, specific drugs for the treatment of various cancers are usually insoluble in water, have large side effects, and are prone to drug resistance. Studies have shown that targeted delivery can solve the above problems. In recent years, scientists from various countries have conducted various researches in the field of nano-controlled release drug delivery systems, such as tumor-responsive pH-controlled release systems, drug-loaded nanoparticles, etc. Although these nano-drug delivery systems can achieve responsive release of drugs at tumor sit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K41/00A61K31/337A61P35/00
CPCA61K49/223A61K41/00A61K31/337A61P35/00A61K49/225A61K49/221
Inventor 黄硕郭雯雨董飞宏张珏
Owner NANJING TRANSCEND VIVOSCOPE BIO TECH CO LTD
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