A primer and kit for detecting gene variation related to prognosis of thyroid cancer

A technology for thyroid cancer and gene mutation, applied in the field of molecular biology, can solve the problems of undetectable low-level mutations, large impact on results, and many operating procedures, so as to improve treatment effects and quality of life, reduce detection costs, and improve The effect of detection efficiency
CN111748628BActive Publication Date: 2022-04-05润安医学科技(苏州)有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
润安医学科技(苏州)有限公司
Publication Date
2022-04-05

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Abstract

The invention provides a primer and a kit for detecting the variation of genes related to the prognosis of thyroid cancer. Based on high-throughput sequencing technology, this method can quickly, comprehensively and accurately detect BRAF gene T1799A, A1801G mutation, TERT gene C228T, C250T mutation, RET gene T2753C mutation, EIF1AX gene G25C / A / T, G370T, G371T mutation and TP53 Gene G818A mutation. The above-mentioned mutations of these genes are closely related to the prognosis of thyroid cancer. Therefore, using the present invention to detect patient samples can assist doctors in evaluating and judging the prognosis of thyroid cancer patients, and provide valuable decision-making basis and guidance for doctors to choose appropriate surgical methods and formulate postoperative follow-up plans in a targeted manner. Reference information is helpful to improve the treatment effect and quality of life of patients with thyroid cancer, and has very important clinical value.
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Description

technical field

[0001] The invention relates to the technical field of molecular biology, in particular to a primer and a kit for detecting gene variation related to the prognosis of thyroid cancer. Background technique

[0002] Thyroid cancer is the most common endocrine malignancy. According to the data of GLOBOCAN2018, the incidence of thyroid cancer in the world accounts for 3.1% of all malignant tumors and 5.1% of female malignant tumors. Since the 1970s, a rapid increase in the incidence of thyroid cancer and a relatively stable mortality rate have been reported in most parts of the world, including the United States, Canada, Europe, Australia, Asia, and parts of South America. According to statistics from the China Cancer Center, the incidence of thyroid cancer among women in my country ranks fourth among all malignant tumors in women.

[0003] Thyroid cancer can be divided into papillary carcinoma, follicular carcinoma, medullary carcinoma, and undifferentiated car...

Claims

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