A preparation method of nanoparticles with pH sensitivity and anticancer activity

Abstract

The present invention relates to a preparation method of nanoparticles with pH sensitivity and anticancer activity. The purpose of the present invention is to provide a kind of high biocompatibility, biodegradable, stable system, and improved drug efficacy in view of the deficiencies of the prior art. The preparation method of the medicine, namely the preparation method of bovine serum albumin-cinnamaldehyde derivative nanoparticles. We chose to use bovine serum albumin (BSA) to covalently graft cinnamaldehyde derivatives to prepare nanoparticles. The prepared nanoparticles are drug carriers with both pH responsiveness and antitumor activity. It can further combine the antitumor drug doxorubicin through physical combination, and through the compounding effect of synergistic administration, the dose of doxorubicin can be reduced while the corresponding lethality rate of cancer cells can be achieved, so as to achieve the purpose of anticancer. And the whole preparation process is green, pollution-free, and has strong operability.

Description

technical field [0001] The invention relates to the technical fields of polymer chemistry, biochemistry, pharmaceutical preparations, etc., and particularly provides a preparation method of nanoparticles with pH sensitivity and anticancer activity. Background technique [0002] The existing proteins used as drug carriers include albumin, collagen, whey protein, etc. From the perspective of biocompatibility, degradability and cytotoxicity, commonly used albumin includes human serum albumin (HSA) And bovine serum albumin (BSA), but HSA can only be obtained from healthy human blood, the market demand is large, the supply is in short supply, the cost of a single source is high, and human blood is more complicated, there are potential threats of various pathogenic microorganisms, So we choose BSA with similar structure, cheap price and high purification degree to replace HSA. In addition to these advantages, the homology between BSA and HSA is as high as 76%, which effectively r...

AI Technical Summary

Problems solved by technology

[0002] The existing proteins used as drug carriers include albumin, collagen, whey protein, etc. From the perspective of biocompatibility, degradability and cytotoxicity, commonly used albumin includes human serum albumin (HSA) And bovine serum albumin (BSA), but HSA can only be obtained from healthy human blood, the market demand is large, the supply is in short supply, the cost of a single source is high, and human blood is more complicated, there are potential threats of various pathogenic microorganisms, So we choose BSA with similar structure, cheap price and high purification degree to replace HSA

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