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Composition for reducing blood sugar and blood fat, and preparation method and application of composition

A ginsenoside, a rare technology, applied in the field of bioengineering, can solve the problems of polluting the environment, unable to directly eat, unable to meet new drugs and other problems

Inactive Publication Date: 2020-10-23
SHAANXI GIANT BIOTECHNOLOGY CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, their hydrolysis conditions are very severe, and aglycones are prone to dehydration or cyclization, which changes the structure of aglycones and increases by-products, making the products difficult to purify and polluting the environment.
The method of preparing rare ginsenosides by microbial transformation method has problems such as difficult to guarantee the safety of microorganisms, cumbersome process, the obtained products need to be separated and purified and cannot be directly eaten, long production cycle, and the conversion rate needs to be improved. Obtaining compound sources can no longer meet the needs of new drug development

Method used

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  • Composition for reducing blood sugar and blood fat, and preparation method and application of composition
  • Composition for reducing blood sugar and blood fat, and preparation method and application of composition
  • Composition for reducing blood sugar and blood fat, and preparation method and application of composition

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preparation example Construction

[0054] The invention provides a preparation method of rare ginsenosides, wherein the preparation method comprises fermenting active raw materials by probiotics.

[0055] Among them, probiotics are a type of active microorganisms that are beneficial to the host by colonizing in the human body and changing the composition of the flora in a certain part of the host. By regulating the immune function of the host mucosa and system or by regulating the balance of intestinal flora, it promotes nutrient absorption and maintains intestinal health, thereby producing single microorganisms or mixed microorganisms with a clear composition that are beneficial to health.

[0056] In a preferred specific embodiment of the present invention, the probiotics include Trichomonas coronoides, Bacillus subtilis and Lactobacillus bulgaricus.

[0057] Described coronoid is commonly called as " golden flower ", belongs to a kind of fungus of the genus Phytomycetes of Phytomycetaceae, is composed of asc...

Embodiment 1

[0126] The preparation of embodiment 1 rare ginsenosides and probiotics

Embodiment 11

[0128] a. Strain activation and expansion

[0129] 1) Cystis coronoides: inoculate the strains of Cystis coronis on the slope of PDA medium, place it at 28°C for cultivation and activate it, and after the hyphae grow all over the slope, wash the mycelium with 5ml of sterile normal saline , inoculate 0.2ml into a 500mL Erlenmeyer flask containing 200mL PDA liquid medium, place it at 28°C, and culture it on a shaker at 160rpm for 120h; Cultivated on a shaker for 72 hours, the number of viable bacteria was measured to be 2.0×10 2 cfu / g;

[0130] 2) Lactobacillus bulgaricus: Inoculate Lactobacillus bulgaricus strains on the modified MRS agar medium plate, place it at 37°C for 48 hours of activation culture, scrape 1 ring with the inoculation loop and inoculate it into a 250mL Erlenmeyer flask containing 80mL MRS liquid medium placed in a shaker at 30°C and 160r / min for 48h, and the number of viable bacteria was measured to be 1.8×10 3 cfu / g;

[0131] 3) Bacillus subtilis: Inoc...

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Abstract

The invention discloses a composition for reducing blood sugar and blood fat as well as a preparation method and application of the composition. The composition for reducing blood sugar and blood fatcomprises rare ginsenoside and probiotic powder, wherein the probiotic powder comprises eurotium cristatum, bacillus subtilis and lactobacillus bulgaricus. The composition provided by the invention can give full play to the effects of reducing blood sugar and blood fat of rare ginsenoside and eurotium cristatum, and has the effects of mutual promotion and synergistic interaction compared with thepure eurotium cristatum or converted rare ginsenoside. Moreover, the composition can realize multiple treatment effects with one medicine, can reduce the medicine taking types of patients suffering from diabetes and hyperlipidemia at the same time, enhances the medical compliance of the patients, and is convenient for the patients to take medicines; and meanwhile, the multiple effects of regulating the proportion of probiotics in intestinal flora, supplementing probiotics, promoting absorption and the like can be achieved at the same time.

Description

technical field [0001] The invention relates to the technical field of bioengineering, in particular to a composition for lowering blood sugar and blood fat, a preparation method and application thereof. Background technique [0002] Diabetes mellitus is a metabolic disorder syndrome that is related to the abnormal production and action of insulin and is characterized by hyperglycemia. Hyperlipidemia is a clinical symptom of lipids in the blood higher than normal levels due to abnormal fat metabolism or operation, usually manifested as hyperlipoproteinemia, hypercholesterolemia, hypertriglyceridemia or both, In addition, hyperlipidemia can also induce the onset of diabetes and impaired glucose tolerance. It is also an important predisposing factor for fatty liver, cirrhosis, cholelithiasis and pancreatitis. Therefore, it is urgent to prevent, alleviate and treat diabetes and hyperlipidemia. [0003] Fu tea is a traditional tea drink in the northwestern border area of ​​my c...

Claims

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Application Information

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IPC IPC(8): A61K36/424A61P3/06A61P3/10A61K35/741A61K35/742A61K35/747
CPCA61K35/741A61K35/742A61K35/747A61K36/258A61K36/424A61K2236/19A61P3/06A61P3/10A61K2300/00
Inventor 范代娣宋养斌段志广马晓轩
Owner SHAANXI GIANT BIOTECHNOLOGY CO LTD
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