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Gel dressing containing icodextrin

A technology of icodextrin and gel, applied in bandages, medical science, etc., can solve problems such as weak protective effect, small molecular weight, and inability to protect the film

Active Publication Date: 2020-10-23
HUAREN PHARMACEUTICAL CO LTD +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the molecular weight of α-glucan oligosaccharides is small, so it cannot form an effective protective film on the skin surface, and the protective effect is weak

Method used

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  • Gel dressing containing icodextrin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Icodextrin 0.8%, Purified Water 91.896%, Hydroxymethylcellulose Sodium 0.5%, Butanediol 5.503%, Caprylyl Hydroxamic Acid 0.5%, Ethylhexylglycerin 0.3%, 1,2-Hexanediol 0.5% %, flavoring agent sweet orange essential oil 0.001%.

Embodiment 2

[0023] Icodextrin 0.8%, Water for Injection 90.07%, Carbomer 0.8%, Triethanolamine 0.6%, Butylene Glycol 6.5%, Caprylyl Hydroxamic Acid 0.5%, Ethylhexylglycerin 0.3%, 1,2-Hexanediol Alcohol 0.4%, flavoring agent peppermint essential oil 0.003%.

Embodiment 3

[0025] Icodextrin 0.6%, Water for Injection 93%, Hydroxymethylcellulose Sodium 0.425%, Triethanolamine 0.003%, Butylene Glycol 5%, Caprylyl Hydroxamic Acid 0.45%, Ethylhexylglycerin 0.219%, 1,2 - Hexylene glycol 0.3%, flavoring agent neroli oil 0.003%.

[0026] Implementation Effect:

[0027] (1) The dressings obtained in the above examples were sealed and left for a week at normal temperature and pressure, and the state of the auxiliary materials was observed every 6 hours. The obtained dressings remained in a stable gel state without delamination or flocculation.

[0028] (2) Take 18 rats, smear or spray the gel dressing obtained in the above examples on the superficial wounds on the right hind legs of the rats (all wounds are 1 cm), apply once every 12 hours, and take 3 groups of wounds Rats healed naturally were used as the control group, and each group contained 3 rats with wounds. The experimental results obtained are shown in the following table:

[0029]

[0030]...

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PUM

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Abstract

The invention provides a gel dressing containing icodextrin. The dressing is prepared by using water for injection or purified water as a carrier and adding the icodextrin, carbomer or carboxymethylcellulose sodium, triethanolamine, butanediol, caprylhydroxamic acid, 3-[2-(Ethylhexyl)oxyl]-1,2-propandiol, 1,2-hexanediol, flavoring agent, etc. The gel dressing containing icodextrin provided by theinvention is in gelatinous form, and can be applied to new scars and minimally invasive wounds to prevent scar hyperplasia and external pollution, reduce the probability of scar formation and avoid pigmentation scars.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to a non-sterile gel dressing containing icodextrin. Background technique [0002] In the medical field, dressings generally refer to external materials that can protect wounds, prevent secondary infection and heat loss. At present, there are mainly traditional gauze dressings and modern dressings. Modern dressings include sodium alginate / calcium dressings, interactive dressings, silver Ionic dressings, foam dressings and gel dressings, etc. [0003] Glucan is a homopolysaccharide composed of glucose as a monosaccharide, which is divided into α-glucan and β-glucan, and each glucan has a variety of bond combinations. As an active ingredient in skin care products, dextran has a long history in the West. Families in many European and American countries are used to bathing infants and young children with water soaked in oatmeal to relieve and prevent eczema; the elderly are also used to...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/008A61L26/0023A61L26/0014A61L26/0061A61L26/0066A61L26/0076A61L2300/232A61L2300/412C08L3/02C08L1/286C08L1/284C08L33/02
Inventor 杨效东冯新光班文溥王盈盈衣思闻
Owner HUAREN PHARMACEUTICAL CO LTD
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