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A gel dressing containing icodextrin

An icodextrin and gel technology, applied in bandages, medical science, etc., can solve the problems of small molecular weight, weak protective effect, and inability to protect the film, so as to reduce damage, reduce the probability of scar formation, and avoid pigmentation scars Effect

Active Publication Date: 2022-04-12
HUAREN PHARMACEUTICAL CO LTD +3
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the molecular weight of α-glucan oligosaccharides is small, so it cannot form an effective protective film on the skin surface, and the protective effect is weak

Method used

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  • A gel dressing containing icodextrin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Icodextrin 0.8%, Purified Water 91.896%, Sodium Hydroxymethyl Cellulose 0.5%, Butanediol 5.503%, Caprylyl Hydroxamic Acid 0.5%, Ethylhexylglycerin 0.3%, 1,2-Hexanediol 0.5% %, flavoring agent sweet orange essential oil 0.001%.

Embodiment 2

[0023] Icodextrin 0.8%, water for injection 90.07%, carbomer 0.8%, triethanolamine 0.6%, butanediol 6.5%, caprylyl hydroxamic acid 0.5%, ethylhexylglycerin 0.3%, 1,2-hexanediol Alcohol 0.4%, flavoring agent peppermint essential oil 0.003%.

Embodiment 3

[0025] Icodextrin 0.6%, Water for Injection 93%, Sodium Hydroxymethylcellulose 0.425%, Triethanolamine 0.003%, Butylene Glycol 5%, Caprylyl Hydroxamic Acid 0.45%, Ethylhexylglycerin 0.219%, 1,2 - Hexylene glycol 0.3%, flavoring agent neroli oil 0.003%.

[0026] Implementation Effect:

[0027] (1) The dressings obtained in the above examples were sealed at room temperature and pressure for a week, and the state of the dressing was observed every 6 hours. The obtained dressings remained in a stable gel state without delamination or flocculation.

[0028] (2) Get 18 rats, smear or spray the gel dressing obtained in the above examples on the superficial wounds of the right hind legs of the rats (the wounds are all 1 cm), apply once every 12 hours, and take 3 groups of wounds Rats healed naturally were used as the control group, and each group contained 3 rats with wounds. The experimental results obtained are shown in the following table:

[0029]

[0030] It can be clearly ...

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Abstract

The invention provides a gel dressing containing icodextrin, which uses water for injection or purified water as a carrier, and adds icodextrin, carbomer or sodium carboxymethylcellulose, triethanolamine, butanediol , caprylyl hydroxamic acid, ethylhexylglycerin, 1,2-hexanediol, flavoring agent, etc., the dressing containing icodextrin of the present invention is in the form of gel, and is used for new scars or minimally invasive At the mouth, prevent scar hyperplasia and external pollution, reduce the chance of scar formation, and avoid pigmentation scars.

Description

technical field [0001] The invention belongs to the field of medical devices, in particular to a non-sterile gel dressing containing icodextrin. Background technique [0002] In the medical field, dressings generally refer to external materials that can protect wounds, prevent secondary infection and heat loss. At present, there are mainly traditional gauze dressings and modern dressings. Modern dressings include sodium alginate / calcium dressings, interactive dressings, silver Ionic dressings, foam dressings and gel dressings, etc. [0003] Glucan is a homopolysaccharide composed of glucose as a monosaccharide, which is divided into α-glucan and β-glucan, and each glucan has a variety of bond combinations. As an active ingredient in skin care products, dextran has a long history in the West. Families in many European and American countries are used to bathing infants and young children with water soaked in oatmeal to relieve and prevent eczema; the elderly are also used to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00
CPCA61L26/008A61L26/0023A61L26/0014A61L26/0061A61L26/0066A61L26/0076A61L2300/232A61L2300/412C08L3/02C08L1/286C08L1/284C08L33/02
Inventor 杨效东冯新光班文溥王盈盈衣思闻
Owner HUAREN PHARMACEUTICAL CO LTD
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