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Degradable artificial bone particles with core-shell structure and preparation method thereof

A technology of core-shell structure and artificial bone, which can be applied to household appliances, ceramic products, and other household appliances, etc., and can solve problems such as difficulty in combining multiple properties, slow degradation rate, and excessive degradation

Active Publication Date: 2020-10-23
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The biological activities of these three phase components are different: HA ceramics have good osteoconductivity, but the degradation rate is relatively slow; β-TCP has high pro-angiogenic activity, but the degradation rate is too fast; Matching with new bone formation speed, osteoconduction ability is lower than HA, but higher than β-TCP, pro-angiogenic ability is higher than HA, but lower than β-TCP
Different host bone environments have different demands on the osteogenic, angiogenic and degradative properties of ceramics. It is often difficult for current calcium phosphate ceramics to have multiple properties at the same time.

Method used

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  • Degradable artificial bone particles with core-shell structure and preparation method thereof
  • Degradable artificial bone particles with core-shell structure and preparation method thereof
  • Degradable artificial bone particles with core-shell structure and preparation method thereof

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preparation example Construction

[0118] The preparation method of the present disclosure is not limited thereto. In some examples, the preparation method of the present disclosure can be used to prepare artificial bone particles with a core-shell structure of three or more layers. For example, the above-mentioned artificial bone particles with a three-layer structure including a single-layer coating layer (referred to as three-layer artificial bone particles) or artificial bone particles with a multi-layer structure including multiple layers of coating layers (referred to as multi-layer artificial bone particles).

[0119] In some examples, the preparation method of the three-layer artificial bone particle can refer to the steps of the above-mentioned double-layer artificial bone particle. The difference is that the third foaming slurry needs to be obtained when preparing the three-layer artificial bone particles. The obtaining of the third foaming slurry can refer to the method for obtaining the first foamin...

Embodiment 1

[0122] In Example 1, a degradable artificial bone particle having a BCP outer shell layer and an HA inner core layer was prepared.

[0123] In Example 1, 4g of BCP powder and 4g of HA powder were weighed and poured into two 250mL glass beakers respectively, 50mL of deionized water was added, and fully stirred with a glass rod. Move the evenly stirred slurry to a numerically controlled ultrasonic cleaner for ultrasonic vibration for 10 min, then transfer the slurry to a 50 mL centrifuge tube, and centrifuge for 3 min at a speed of 3000 r / min in a low-speed centrifuge.

[0124] In Example 1, the supernatant in the centrifuge tube was removed, and the ceramic precipitate was put into a 250mL beaker, and a volume of 10mL of sodium alginate (Na Alg) with a mass fraction of 6wt%, and a volume of 2mL with a mass fraction of 2wt% methyl cellulose (MC), mixed evenly with an emulsifying homogenizer. Then add a volume of 1.5 mL of 30% H 2 o 2 and 20 mL of deionized water, using a high...

Embodiment 2

[0130] In Example 2, a degradable artificial bone particle having a β-TCP outer shell layer and an HA inner core layer was prepared. The preparation method refers to Example 1. The difference between the preparation method in Example 2 and the preparation method in Example 1 is that the powders selected in Example 2 are 4g HA powder and 4g β-TCP powder. In addition, after adding H 2 o 2 When fully stirred with deionized water using a high-speed stirrer, the deionized water is 15mL. The β-TCP foaming slurry was extruded from the shell channel of the coaxial double-layer needle. Extrude the HA foaming slurry from the core channel of the coaxial double-layer needle.

[0131] In Example 2, the outer shell layer of the degradable artificial bone particles in which β-TCP is the outer shell layer and HA is the inner core layer has strong angiogenesis ability, and the inner core layer degrades slowly to provide mechanical support. It is suitable for the repair of femoral head nec...

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Abstract

The invention discloses degradable artificial bone particles with a core-shell structure. The particles are characterized in that: the particles have a core-shell structure, the core-shell structure comprises an inner core layer and an outer shell layer coating the outer surface of the inner core layer, the material of the inner core layer is different from that of the outer shell layer, the innercore layer and the outer shell layer are in a ceramic phase, the degradation rate of the inner core layer is smaller than that of the outer shell layer, the outer shell layer is of a porous structure, the porous structure comprises a plurality of through holes with a first hole diameter and a plurality of micropores with a second hole diameter, the through holes are communicated with one another,the inner core layer is selected from at least one of hydroxyapatite, beta-tricalcium phosphate and biphasic calcium phosphate, and the outer shell layer is selected from at least one of hydroxyapatite, beta-tricalcium phosphate and biphasic calcium phosphate. According to the present disclosure, the artificial bone particles which meet the requirements of both osteogenesis, vascularization and degradability of ceramics can be obtained.

Description

technical field [0001] The present disclosure generally relates to the field of clinical bone repair, and specifically relates to a degradable artificial bone particle with a core-shell structure and a preparation method thereof. Background technique [0002] Bone defect is one of the common clinical diseases, such as trauma, inflammation, bone disease, surgery and other factors can cause bone tissue defect. At present, there are many methods for treating bone defects, such as autologous bone transplantation and allogeneic bone transplantation. Although autologous bone grafting is the gold standard for clinical bone defect repair, its bone supply is limited, shaping is difficult, and it cannot meet the repair requirements of large-scale specific shapes. Although allogeneic bone can solve the problem of limited bone source, it is prone to absorption deformation and strong antigenicity after implantation, which affects the therapeutic effect. [0003] In order to solve the a...

Claims

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Application Information

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IPC IPC(8): A61L27/58A61L27/50A61L27/56A61L27/12A61L27/10A61L27/20C04B35/447C04B35/622C04B35/64C04B38/02
CPCA61L27/10A61L27/12A61L27/20A61L27/50A61L27/56A61L27/58A61L2430/02C04B35/447C04B35/622C04B35/64C04B38/009C04B2235/3212C04B2235/6562C04B2235/6567C04B38/02C04B38/0051C04B38/0054C08L5/04
Inventor 杨晓杨龙朱向东张兴栋
Owner SICHUAN UNIV
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