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Double-gradient artificial vertebral lamina and preparation method thereof

A dual-gradient, artificial technology, applied in the field of biomedical materials, can solve the problems of insufficient compatibility and anti-adhesion, poor new bone formation ability, no osteoinductivity, etc., and achieve good osteoconduction and osteoinduction ability, Good soft tissue compatibility and anti-adhesion ability, excellent osteoinductive effect

Active Publication Date: 2018-08-10
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the materials of artificial lamina generally include stainless steel, titanium or titanium alloy, bioactive ceramics, active glass, etc., but the above-mentioned artificial lamina has insufficient histocompatibility and anti-adhesion, and is not osteoinductive or osteoinductive. , leading to poor new bone formation

Method used

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  • Double-gradient artificial vertebral lamina and preparation method thereof
  • Double-gradient artificial vertebral lamina and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1. A dual-gradient artificial vertebral plate

[0029] The artificial vertebral plate described in Example 1 is a matrix with a trapezoidal cross-section and an axial length. The matrix is ​​composed of an upper layer, a middle layer and a lower layer. The upper and lower layers are hydroxyapatite ceramic layers 1. The middle layer is a two-phase calcium phosphate ceramic layer 2, and the upper and lower layers are dense structure layers with a thickness of 1 mm. The middle layer is a porous structure layer with a porosity of 75%.

[0030] Preparation:

[0031] A) Raw material preparation:

[0032] Preparation of nano-hydroxyapatite powder or slurry: mix 0.835mol / L calcium nitrate aqueous solution and 0.5mol / L diammonium hydrogen phosphate aqueous solution in equal volume, the ratio of calcium to phosphorus is 1.67, and the pH of the solution is adjusted to 11.0 with ammonia water. Stir the reaction for 12h, then aging at 60℃ for 24h, wash with deionized water to obta...

Embodiment 2

[0038] Example 2. A dual-gradient artificial vertebral plate

[0039] The difference between Example 2 and Example 1 is that in steps B) and C), the binder is polyethylene glycol, the dispersant is citric acid, and the pore former is polymethyl methacrylate. The step D ) The isostatic pressure is 300 MPa, and the step E) is: placing the green body in the cavity of the muffle furnace sintering furnace, sintering in the muffle furnace, and increasing the temperature at a temperature rise rate of 0.5°C / min To 150℃, keep for 10min; then increase the temperature to 500℃ at a heating rate of 0.5℃ / min and keep it for 10minh; then increase the temperature to 600℃ at a heating rate of 0.5℃ / min, keep it for 30min to decompose organic matter; continue to use Muffle furnace sintering, heating up to 1000°C at a heating rate of 10°C / min, holding time 1h, and reducing the temperature to room temperature at a cooling rate of 20°C / min, cutting to obtain an artificial lamina with double gradients...

Embodiment 3

[0040] Example 3. A dual-gradient artificial vertebral plate

[0041] The difference between Example 3 and Example 1 is that in steps B) and C), the binder is polyethylene glycol, the dispersant is ammonium citrate, and the pore former is polystyrene. The step D) The isostatic pressure is 500 MPa, and the step E) is: placing the green body in the cavity of the muffle furnace sintering furnace, sintering in the muffle furnace, and raising the temperature to 250 at a heating rate of 20°C / min ℃ for 2h; then increase the temperature to 500℃ at a heating rate of 3℃ / min and keep it for 4h; then increase the temperature to 800℃ at a heating rate of 20℃ / min and keep it for 4h to decompose organic matter; continue to use muffle Furnace sintering, heating up to 1200°C at a heating rate of 20°C / min, holding time 4h, and lowering the temperature to room temperature at a cooling rate of 100°C / min; cutting to obtain a double-gradient artificial lamina with a porosity of 74% .

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Abstract

The invention belongs to the technical field of biomedical materials and in particular relates to a double-gradient artificial vertebral lamina and a preparation method thereof. The double-gradient artificial vertebral lamina is a base body with a trapezoid cross section and an axial length, wherein the base body is composed of an upper layer, a middle layer and a lower layer; the upper layer andthe lower layer are dense hydroxyapatite ceramic layers; the middle layer is a porous double-phase calcium phosphate ceramic layer. The artificial vertebral lamina provided by the invention has a dense / porous / dense trapezoid sandwich structure; compared with the prior art, the artificial vertebral lamina has higher tissue compatibility and anti-adhesion performance; meanwhile, the artificial vertebral lamina has excellent osteoinduction performance, is simple in structure and convenient to implant and is suitable for being popularized and applied in a large range.

Description

Technical field [0001] The invention belongs to the technical field of biomedical materials, and specifically relates to a dual-gradient artificial lamina and a preparation method thereof. Background technique [0002] Posterior laminectomy (including full laminectomy, half laminectomy, partial laminectomy, etc.) is the most basic and commonly used surgical operation in spinal surgery. Its scope of application covers almost all spinal surgery diseases, especially patients with Patients with cervical, thoracic and lumbar spinal stenosis. Although laminectomy can effectively relieve the compression of the spinal cord and nerves and relieve the patient's symptoms, laminectomy (loss) loses its original barrier protection effect on the spinal canal, and a large amount of scar tissue proliferates in the defect area and extends to the spinal canal. Ingrowth may even cause compression, adhesion, and traction on the spinal cord and nerve roots again, resulting in surgical failure. ...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/12A61L27/10A61L27/56A61L27/50C04B35/447C04B35/622C04B38/06
CPCA61L27/10A61L27/12A61L27/50A61L27/56A61L2430/38C04B35/447C04B35/622C04B38/0645C04B2235/5427C04B2235/5436C04B2235/5445C04B2235/5454C04B2235/602C04B2235/656C04B2235/6562C04B2235/6565C04B2235/6567C04B2235/667C04B2235/75C04B2235/96
Inventor 朱向东吴永豪刘丹李向锋杨曦宋跃明张兴栋
Owner SICHUAN UNIV
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