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Method for preparing pinellia syrup micro-capsule granules

A technology of Pinellia and granules, applied in the field of preparing Pinellia dew microcapsule granules, can solve the problems that patients are afraid to use with confidence, are susceptible to damp, mildew and deteriorate, and affect the effect of treatment, so as to reduce the leakage of peppermint oil, improve the encapsulation effect, Efficiency-enhancing effect

Inactive Publication Date: 2020-10-27
右江民族医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The currently commercially available Banxialu preparations are mainly Banxialu granules. According to market sales, patient feedback and finished product sample inspection, Banxialu granules contain volatile components of peppermint oil, and the volatile oil will be lost during storage. It seeps out slowly, resulting in changes in the appearance of the finished product, and even mildew spots, which makes many patients afraid to use it with confidence
During storage, the granules are prone to moisture, mildew and deterioration, which will affect the efficacy of the medicine and directly affect the effect of treatment.
Moreover, Banxialu granules have a relatively strong taste of traditional Chinese medicine, which some consumers cannot accept

Method used

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  • Method for preparing pinellia syrup micro-capsule granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A method for preparing pinellia microcapsules, comprising the steps of:

[0031] (1) Weigh each raw material according to the following prescription: 79.2g raw pinellia, 79.2g loquat leaves, 50.7g polygala (bubble), 47.4g coltsfoot flower, 31.5g bellflower, 31.5g ephedra, 31.5g licorice, 47.4g tangerine peel, Peppermint oil 3ml;

[0032] (2) Take the raw pinellia, moisten it, flatten it, add 6 times of water to decoct twice, decoct for 2 hours each time, filter, concentrate the filtrate to a relative density of 1.05, let it cool, add ethanol with a concentration of 95% to soak , precipitated for 24 hours, took the supernatant, recovered the ethanol for later use, and obtained the raw pinellia medicinal liquid; took another tangerine peel, added 90% ethanol that was 4 times its weight, and soaked for 24 hours, then percolated at a rate of 5ml per minute. , after complete percolation, recover the ethanol for later use, and obtain the tangerine peel medicinal liquid; add ...

Embodiment 2

[0037] A method for preparing pinellia microcapsules, comprising the steps of:

[0038] (1) Weigh each raw material according to the following prescription: 79.2g raw pinellia, 79.2g loquat leaves, 50.7g polygala (bubble), 47.4g coltsfoot flower, 31.5g bellflower, 31.5g ephedra, 31.5g licorice, 47.4g tangerine peel, Peppermint oil 3ml;

[0039] (2) Take the raw pinellia, moisten it, flatten it, add 7 times of water to decoct twice, decoct for 2 hours each time, filter, concentrate the filtrate to a relative density of 1.10, let it cool, add ethanol with a concentration of 95% to soak , precipitated for 24 hours, took the supernatant, recovered the ethanol for later use, and obtained the raw pinellia medicinal liquid; took another tangerine peel, added 90% ethanol 5 times its weight, and soaked for 24 hours, then percolated at a rate of 5ml per minute. , after complete percolation, recover the ethanol for later use, and obtain the tangerine peel medicinal liquid; add loquat le...

Embodiment 3

[0044] A method for preparing pinellia microcapsules, comprising the steps of:

[0045] (1) Weigh each raw material according to the following prescription: 79.2g raw pinellia, 79.2g loquat leaves, 50.7g polygala (bubble), 47.4g coltsfoot flower, 31.5g bellflower, 31.5g ephedra, 31.5g licorice, 47.4g tangerine peel, Peppermint oil 3ml;

[0046] (2) Take the raw pinellia, moisten it, flatten it, add 5 times the water to decoct twice, decoct for 2 hours each time, filter, concentrate the filtrate to a relative density of 1.05, let it cool, add 95% ethanol to soak , precipitated for 24 hours, took the supernatant, recovered the ethanol for later use, and obtained the raw pinellia medicinal liquid; took another tangerine peel, added 90% ethanol 3.5 times its weight, and soaked for 24 hours, then percolated at a rate of 3ml per minute. , after complete percolation, recover ethanol for later use, and obtain tangerine peel medicinal liquid; add loquat leaves, Zhiyuan (soaked), colts...

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Abstract

The invention discloses a method for preparing pinellia syrup micro-capsule granules. The method comprises steps as follows: raw pinellia ternate, folium eriobotryae, soaked radix polygalae, flos farfarae, radix platycodi, herba ephedra, licorice root, pericarpium citri reticulatae and peppermint oil are weighed according to the prescription; medical solutions are obtained by extraction and are combined and concentrated, extract is obtained and dried by a pulse air-streaming drier, and dry pinellia syrup paste powder is obtained; tea saponin, rhamnolipid, konjac glucomannan, carrageenan and Arabic gum are added to water, heated and stirred uniformly, and a capsule wall material solution is obtained; the dry pinellia syrup paste powder and the peppermint oil are added to a homogenizer and mixed uniformly, then the capsule wall material and a plasticizer are added, homogenizing treatment is performed, and a mixed drug is obtained; and the mixed drug is added to a spray fluidized bed andsubjected to drying and granulation, and the pinellia syrup micro-capsule granules are prepared. According to the method, the pinellia syrup drug is subjected to microencapsulation treatment, efficient encapsulation for the drug is effectively realized, leakage of the peppermint oil can be reduced, the drug is prevented from being affected with damp, drug stability is improved, and storage life isprolonged; and besides, objectionable odor of the pinellia ternate granules can be covered, and the pinellia syrup micro-capsule granules are easily accepted by patients.

Description

technical field [0001] The invention relates to the technical field of Chinese patent medicine preparations, in particular to a method for preparing Banxialu microcapsule granules. Background technique [0002] Pinellia dew preparation is a traditional Chinese medicine preparation made from raw pinellia, loquat leaves, polygala (bubble), coltsfoot, bellflower, ephedra, licorice, tangerine peel, and peppermint oil. It has been sold in the market. Its pharmacological effects are: the effect of clearing the lung and relieving cough, and the effect of harmonizing the stomach and reducing thirst, and can be used for cough due to lung heat, dyspnea due to adverse qi, vomiting due to stomach heat, phlegm and cough, and can treat cough and wheezing; polygala can eliminate phlegm Relieve cough, cough and spit out uncomfortable or exogenous wind-cold, cough with phlegm. [0003] Microencapsulation technology uses natural or synthetic polymer encapsulation materials (collectively refe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8888A61K9/50A61K47/46A61K47/36A61K47/26A61K47/24A61K47/14A61P11/06A61P11/14
CPCA61K9/5036A61K9/5063A61K36/17A61K36/28A61K36/346A61K36/484A61K36/534A61K36/69A61K36/73A61K36/752A61K36/8888A61K47/14A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61P11/06A61P11/14A61K2300/00
Inventor 黄锁义李惠莉雷智冬黄与路
Owner 右江民族医学院
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