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A composition and skin care product for inhibiting hyaluronidase activity

A hyaluronidase and skin care technology, applied in the field of daily chemicals, can solve the problems of no hyaluronidase inhibitor and easy degradation of hyaluronic acid, and achieve the effects of improving moisturizing effect, reducing degradation speed and improving stability

Active Publication Date: 2022-07-12
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problem that hyaluronidase is easy to degrade hyaluronic acid due to the presence of hyaluronidase in the prior art, and there is no particularly effective hyaluronidase inhibitor used in cosmetics, the present invention provides a combination that inhibits hyaluronidase activity and skin care products comprising the composition inhibiting hyaluronidase activity

Method used

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  • A composition and skin care product for inhibiting hyaluronidase activity
  • A composition and skin care product for inhibiting hyaluronidase activity
  • A composition and skin care product for inhibiting hyaluronidase activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Add 100 mL of water to the dissolving tank, slowly add 5 g of L-glutamic acid, 2 g of theanine, and 0.5 g of mannose into the dissolving tank, stir to dissolve all, and mix evenly to obtain a composition solution.

[0042] The composition solution was stirred at 80° C. for 4-6 hours, condensed to a solid state with liquid nitrogen, placed in a freeze dryer (Yaxing, LGJ-10N) for 24-48 hours of freeze-drying process, until the solvent was completely removed to obtain Composition powder for inhibiting hyaluronidase activity.

Embodiment 2-6

[0044] Example 2-Example 6 is different from Example 1 in that the dosages of glutamic acid, theanine and mannose are different, and the specific parameters are shown in Table 1.

Embodiment 7

[0076] Example 7 Preparation of skin care products

[0077] A skin care product is formulated and prepared as follows:

[0078] (1) Add 0.5 g of sodium hyaluronate (molecular weight 1.5 million, batch number 1810195) into 50 mL of water, and stir until completely dissolved;

[0079] (2) adding glutamic acid, theanine, mannose, preservatives, and functional ingredients to the mixture of step (1), stirring to make them all dissolved, and adding water to make up the volume to 100 mL;

[0080] (3) Adjust pH to 6.5 with 0.1% NaOH solution to obtain a skin care product.

[0081] According to the above preparation method, the skin care products of Example 7-1 and Comparative Examples 7-1 to 7-8 were prepared according to the content of each raw material in the raw material composition comparison table in Table 4.

[0082] Wherein, in the step (3) of Comparative Examples 7-7, the pH was adjusted to 4.5 to obtain a skin care product.

[0083] In Comparative Examples 7-8, in step (3)...

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Abstract

The present invention provides a composition for inhibiting hyaluronidase activity, the composition comprising glutamic acid, theanine and mannose. The present invention also provides a skin care product, characterized in that the skin care product comprises a composition for inhibiting hyaluronidase activity and hyaluronic acid. The composition for inhibiting hyaluronidase activity provided by the present invention has obvious inhibitory effect on hyaluronidase activity. Half inhibitory dose (IC 50 ) can be as low as 0.17 mg / mL. It can also improve the stability of hyaluronic acid solution and reduce the degradation speed of hyaluronic acid in solution state. In the skin care product provided by the present invention, the composition for inhibiting the activity of hyaluronidase can promote the exertion of the efficacy of hyaluronic acid itself and enhance the moisturizing effect of hyaluronic acid.

Description

technical field [0001] The invention belongs to the field of daily chemicals, and in particular relates to a composition for inhibiting the activity of hyaluronidase and a skin care product. Background technique [0002] Hyaluronic Acid (HA) is a natural mucopolysaccharide formed from alternating units of D-glucuronic acid and N-acetylglucosamine in a linear chain. With its unique molecular structure and physicochemical properties, hyaluronic acid exhibits a variety of important physiological functions in the body, such as lubricating joints, regulating the permeability of blood vessel walls, regulating proteins, and promoting wound healing. Most importantly, it has a special water-retaining effect, and it is the substance with the best moisturizing property found in nature so far, which is called the ideal natural moisturizing factor (NMF). [0003] Hyaluronic acid is a multifunctional matrix that is widely distributed in various parts of the human body. The maturation an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/60A61K8/44A61Q19/00
CPCA61K8/60A61K8/44A61Q19/00A61K2800/5922A61K2800/782
Inventor 王静耿凤邵萌郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD