Anti-dandruff scalp essence containing rose fermented liquid and preparation method thereof

A fermentation liquid, rose technology, applied in medical preparations containing active ingredients, skin care preparations, pharmaceutical formulas, etc., can solve the problems of scalp flora imbalance, loss of efficacy, emergence of drug resistance, etc., to improve flora balance , inhibiting the production of inflammatory factors and reducing the effect of

Active Publication Date: 2022-06-28
上海洁士宝日化集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The currently used anti-dandruff ingredients are mainly designed for Malassezia colonized on the scalp, but the inhibition of a single flora may lead to rapid emergence of drug resistance and loss of efficacy, and may also make the scalp flora more unbalanced, causing other problems

Method used

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  • Anti-dandruff scalp essence containing rose fermented liquid and preparation method thereof
  • Anti-dandruff scalp essence containing rose fermented liquid and preparation method thereof
  • Anti-dandruff scalp essence containing rose fermented liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0051] The embodiment of the present invention also relates to the preparation method of this anti-dandruff scalp essence, comprising the following steps:

[0052] (1) mixing pure water and acrylic acid (ester) / C10-30 alkanol acrylate cross-linked polymer to obtain A phase for subsequent use;

[0053] Mix denatured ethanol, panthenol, aminomethyl propanol, sodium hyaluronate, rose fermentation broth and allantoin to obtain phase B for subsequent use;

[0054] Ethylhexylglycerol and phenoxyethanol are mixed to obtain phase C for subsequent use;

[0055] The amount of pure water in phase A and phase B can be allocated as follows: pure water in phase A accounts for 40% to 55% of the total mass of pure water, and the remaining pure water is added to phase B;

[0056] (2) Turn on the stirring function of the stirring pot, add the pure water in the A phase into the stirring pot, then add acrylic acid (ester) / C10-30 alkanol acrylate cross-linked polymer, heat to 70~75℃ and stir unt...

preparation example 1

[0085] 1) Preparation of rose fermentation substrate: pulverize dried rose buds and pass through a 100-mesh sieve, add water to prepare a mixed solution with a mass concentration of 10%, and sterilize at 121° C. for 15 minutes to obtain a rose fermentation substrate.

[0086] 2) Bacterial activation: Dip Bacillus natto CICC 10262 with a sterilized bamboo stick, streak the solid activated medium according to the plate streaking method, and invert aerobic cultivation in a constant temperature incubator at 37°C for 15 to 20 hours. An activated Bacillus natto CICC 10262 strain was obtained.

[0087] Dip Lactobacillus bulgaricus CICC 20271 with a sterilized bamboo stick, streak on the solid activated medium according to the plate streaking method, and invert anaerobic cultivation in a constant temperature incubator at 37°C for 15-20 hours to obtain the activated Lactobacillus bulgaricus CICC20271 strain .

[0088] Dip the Saccharomyces cerevisiae CICC 1252 with a sterilized bamboo...

Embodiment 1

[0127] In Examples 1-7 and Comparative Examples 1-2, the B-phase components and the addition amount were changed, and other operation steps and testing procedures were the same as those in Example 1. The specific setting methods are shown in Table 5.

[0128] table 5

[0129]

[0130]

[0131] Among them, the meaning of "remainder of pure water" is: take the total mass of anti-dandruff scalp essence as 100 parts, subtract the raw materials in phase B except pure water, and phase A and phase C from 100 parts, and the rest is It is the weight part of pure water in B phase.

[0132] Scalp Use Test

[0133] Selected 80 volunteers with mild dandruff problems in the age range of 18-60 years old, both men and women, aged between 18 and 60 years old. The above volunteers were randomly divided into 8 groups with 10 people in each group. Among them, groups 1 to 5 are experimental groups, and the anti-dandruff scalp essences prepared in Examples 1 to 5 and Comparative Examples...

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Abstract

The invention provides an anti-dandruff scalp essence containing rose fermented liquid, wherein the rose fermented liquid is rich in polysaccharides, flavonoids and amino acids. The flavonoids contained in it act on the scalp microbes and can selectively inhibit the growth of Malassezia and Staphylococcus without inhibiting the growth of Propionibacterium, thus balancing the scalp flora. Contains polysaccharides to keep the scalp moist and amino acids to strengthen the scalp barrier. Therefore, the anti-dandruff scalp essence can regulate the microecology of the scalp, improve the health of the scalp from multiple dimensions, and achieve the effect of anti-dandruff and nourishing the scalp.

Description

technical field [0001] The invention relates to the technical field of light chemical industry, in particular to an anti-dandruff scalp essence containing rose fermentation liquid, and a preparation method of the anti-dandruff scalp essence. Background technique [0002] Dandruff is a common disease. According to incomplete statistics, the prevalence of dandruff in the post-adolescent population worldwide is 50%, and its causes and pathogenesis are very complex. At present, most studies believe that microbiological factors, sebaceous gland secretion and individual susceptibility are the three most important factors for the occurrence of dandruff. [0003] Microbiological factors and local immune responses play a major role in the pathogenesis of dandruff. Many microorganisms are distributed on human skin, among which the fungi distributed on the scalp are mainly Malassezia sp., and the bacteria are mainly Staphylococcus sp. and Propionibacterium sp. [0004] Malassezia col...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61Q5/00A61Q5/12A61Q17/00A61P31/02A61P31/04
CPCA61K8/9789A61Q5/006A61Q5/12A61Q17/005A61P31/02A61P31/04A61K2800/782A61K2800/85
Inventor 张启清余海励杨水波孙绪友
Owner 上海洁士宝日化集团有限公司
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