A kind of space-time controllable degradation film-coated metal material and its preparation method

Abstract

The invention relates to a time-space controllable degradation film-coated metal material and a preparation method thereof. The film-coated metal material is a metal material covered with a film layer, and the metal material includes a metal matrix element and a metal combination element. The metal matrix element is Mg or Zn, and the mass ratio of the metal matrix element to the metal material is 50% to 99%. The coated metal material regulates its electrode potential by regulating the composition of the alloy elements, and makes the grain size in the alloy by regulating the processing technology. Increase or decrease along a specific direction, and process the surface of the metal material to regulate the combination with the interface layer and the polymer layer, so as to realize the precise controllability of the degradation of the coated metal material in time and space. The degradable film-coated metal material prepared by the invention has space-time controllable degradation performance and good biocompatibility, and is suitable for the field of biomedical materials.

Description

A spatiotemporally degradable film-coated metal material and its preparation method technical field The present invention relates to a kind of space-time controllable degradation film-coated metal material and preparation method thereof, and this material can be applied to Fields of hard and soft tissue replacement in living organisms, including orthopaedics, dentistry, cardiovascular, biological cavity, ophthalmology, ENT Repair and replacement products in the fields of medicine, internal medicine, skin, soft tissue, etc. belong to the technical field of new biomedical material preparation. Background technique Magnesium (Mg) as a kind of essential macroelement of human body, the content in human body is second only to Na, K, Ca, ranking fourth It is involved in the synthesis of some proteins and enzymes and some metabolic processes in the human body. The human body needs to consume 300 per day from food ~400mg of Mg to meet the normal physiological function of the...

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Problems solved by technology

[0011] 1) Although the preparation methods of gradient structure materials are rich and diverse, the patent CN101314178B reports the use of twin-roll strip continuous casting process to use element segregation to achieve the purpose of gradient distribution of alloy content in the nanometer to micrometer scale in the thickness direction of the strip, but there is no Controllable gradual change of gradient structure in the length direction of large scale

[0012] 2) In order to improve the bonding force between the metal substrate and the degradable polymer coating and slow down the degradation rate of the metal substrate, the patent CN102008751B reports the preparation of a polymer transition layer, a chemical coupling layer and a degradable polymer function on the surface of the metal substrate layer, thereby preparing biodegradable scaffold composites, but the degradation of the metal matrix is ​​uncontrollable

But this is only modified on the surface of the metal substrate. The composition and microstructure inside the substrate have not been effectively controlled, and the amorphous titanium oxide film is brittle and prone to stress cracking. Once the film on the surface of the material is defective, the internal material will be degraded. process is still out of control

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