Multi-layer copper-based zeolite fiber medical material, medical protective article and manufacturing method thereof

Abstract

The purpose of the present invention is to provide a medical material which has both safe cytotoxicity and efficient antibacterial and antiviral properties, a medical protective article, and a manufacturing method thereof. The multilayer copper-based zeolite fiber medical material has a four-layer structure which sequentially comprises an outermost layer, a first middle layer, a second middle layer and an innermost layer, wherein the outermost layer and the second middle layer are copper-based zeolite fiber layers, the first middle layer is a hydrophobic fiber layer, the innermost layer is a hydrophilic fiber layer, the porosity of the copper-based zeolite fiber layer on the outermost layer is greater than that of the hydrophobic fiber layer on the first middle layer; each copper-based zeolite fiber layer comprises copper-based zeolite and fiber yarn formed by winding fibers; the copper-based zeolite is independently dispersed on the surface of the fibers, and the mass of the copper-based zeolite is reduced in a gradient mode from outside to inside along the radial interface of the fiber line. The medical material and the prepared medical protective article have the two technical advantages of low cytotoxicity and high antibacterial and antiviral properties, have the effect of efficiently killing viruses (especially novel coronavirus) and enough biological safety, are expectedto rebuild the industrial standard of medical respirators, and have very high theoretical and industrial practical values.

Description

Technical field [0001] The present invention relates to prevention sanitary appliances, and more particularly relates to a medical material having a sufficiently low cytotoxicity and high enough antibacterial and antiviral properties, particularly suitable for use to kill viruses niikappu biosafety medical material and medical protective equipment. Background technique [0002] Sudden emerging infectious diseases cause great harm to human health as well as social, political and economic. Coronavirus is a large family of viruses that can cause colds, the Middle East Respiratory Syndrome (MERS), severe acute respiratory syndrome (SARS) and the novel coronavirus pneumonia (COVID-19) and other infectious diseases. Where, (SARS-CoV-2) main relay route novel coronavirus are: direct transmission, aerosol transmission, contact transmission and so on. Therefore, protective wear personal protective equipment is a viral infection, one of the most effective protective measures. [0003] For ...

AI Technical Summary

Problems solved by technology

When the concentration of divalent copper ions in the solution is 0.5ppm or 5ppm, the cytotoxicity is grade 1, but it does not have antibacterial and antiviral functions; when the concentration of divalent copper ions in the solution is 10ppm, the cytotoxicity is grade 4, It has certain antibacterial and antiviral functions, but its cytotoxicity is much higher than the industry standard on cytotoxicity, and cannot meet the requirements of medical masks or medical surgical masks

2) During the wearing process of the mask, when droplets or aerosols pass through the mask layer with copper elements, since copper ions are extremely soluble in aqueous solution, the aerosol is very easy to exchange substances (including ion exchange) with the copper elements in the mask fiber layer. ), so that the copper element enters the mouth and nose, and wearing masks with copper elements for a long time will cause certain damage to the body, especially for medical staff and epidemic prevention personnel who have been wearing masks.

[0010] It can be seen that the content of copper element is low, and the antibacterial and antiviral performance effect cannot be achieved; on the contrary, in order to achieve efficient antibacterial and antiviral performance, the content of copper element is high, and its cytotoxicity must be sacrificed, which cannot meet the requirements of the relevant cell in the medical mask industry standard. The regulation of toxicity (referring to the interrelationship of copper ion amount and cytotoxicity, antiviral property among comparative examples 1-4 in table 1 of specification sheet)

[0011] At present, the copper element used in the preparation of masks mainly includes three forms of copper element, monovalent copper ion compound, and divalent copper ion compound. These three forms are used in the preparation of medical masks or medical surgical masks. There are inherent defects: ( 1) In the form of nanometer, micron copper particles, copper wire, etc.

The antiviral and antibacterial effect of divalent copper ions is better than that of simple copper, but divalent copper ions are easy to fall off and dissolve in water. The content of divalent copper ions in the final synthesized copper fiber is extremely low, and the antiviral and antibacterial effects are not good.

Therefore, the medical protective mask involved in this invention obtains antibacterial and antiviral effects at the expense of biological safety, and is not suitable for medical staff to wear for a long time against the new coronavirus, and is not suitable for medical protective masks against the new coronavirus

[0016] In addition, the mask materials containing copper elements in the prior art, such as patent CN 100490925C (a bactericidal anti-virus mask and its preparation method), patent CN 102171322B (dry disinfection patch for reducing virus body transmission), patent CN111235871A ( Antiviral filter layer made by copper-containing chitosan fiber and its application), patent CN111264932A (a new type of antibacterial surgical protective mask), etc., the copper element will inevitably destroy the cell structure if it wants to achieve high antibacterial and antiviral properties. increase cytotoxicity

[0017] In summary, the problem in the prior art is that materials containing copper elements (copper elemental, monovalent copper ion compounds, divalent copper ion compounds, including copper ion modified zeolite materials) can be used for civilian masks, but cannot be used Medical masks with high biological safety requirements

That is, in order to achieve the cytotoxic biosafety index of medical masks or medical surgical masks, it is inevitable that antibacterial and antiviral properties cannot be achieved; on the contrary, to achieve efficient antibacterial and antiviral properties, it is necessary to sacrifice the requirements of cytotoxicity, which cannot meet the requirements of medical masks. Biosafety Requirements for Masks

That is to say, the existing technology cannot satisfy the high enough antibacterial and antiviral properties and low enough cytotoxicity of copper-containing materials at the same time, that is, the copper-containing materials cannot simultaneously realize the safety of copper on the mask and kill bacteria and viruses High efficiency, unable to meet the regulations on cytotoxicity of medical masks

Further, according to the structure of the existing mask cover body, it is impossible to realize that the mask containing copper element material is used for medical masks with high biological safety requirements.

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