Preparation method of hydrogel drug carrier with light control characteristics
A hydrogel and drug technology, which is applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as the disappearance of functional units, and achieve controlled release, great social benefits and economic benefits. efficiency, the effect of improving the loading and controlled release capacity
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[0037] The invention provides a preparation method of a hydrogel drug carrier with light control characteristics. Firstly, p-diaminoazobenzene is dissolved in dimethylformamide, and triethylamine and acryloyl chloride are added to react to generate azobenzene crosslinking. agent; then mix the prepared azobenzene cross-linking agent with hydroxyethyl methacrylate (HEMA) monomer and vinylpyrrolidone (NVP), add the initiator to form a composite hydrogel drug carrier, and finally pass the drug through the adsorbed way or copolymerization loaded into the hydrogel drug carrier.
[0038] Further, the present invention specifically includes the following steps:
[0039] S1, preparation of azobenzene crosslinking agent:
[0040] Dissolve p-diaminoazobenzene (p-dihydroxyazobenzene or m-diaminoazobenzene or other azobenzene derivatives with amino, carboxyl, and hydroxyl substitution groups on azobenzene) in dimethylformamide Add triethylamine, then add acryloyl chloride dropwise with a...
Embodiment 1
[0044] S1, preparation of azobenzene crosslinking agent:
[0045] p-Diaminoazobenzene (265 mg, 1.25 mmol) was dissolved in 20 mL of dimethylformamide (DMF), and triethylamine (540 μL, 3.875 mmol) was added, then acryloyl chloride (305 μL, 3.75mmol), the reactant was stirred overnight at room temperature; the reacted solution was poured into 600mL water, and the pH of the mixture was adjusted to 4 by adding concentrated HCl aqueous solution dropwise; the precipitated orange solid was collected by suction filtration, and washed with saturated NaHCO 3 Wash once with distilled water, and then freeze-dry with a freeze dryer (-50°C, 7-8 Pa) to obtain the desired orange powder product, that is, the azobenzene crosslinking agent;
[0046] S2, preparation of composite hydrogel drug carrier:
[0047] Add hydroxyethyl methacrylate (HEMA, 2 mL) and N-vinylpyrrolidone (NVP, 465 μL) into a 10 mL centrifuge tube for mixing and shaking, then add azobenzene crosslinker (2.54 mg) to the mixtu...
Embodiment 2
[0049] S1, preparation of azobenzene crosslinking agent:
[0050] p-Diaminoazobenzene (265 mg, 1.25 mmol) was dissolved in dimethylformamide (DMF, 20 mL), and triethylamine (2.5 mmol) was added, followed by the dropwise addition of acryloyl chloride (2.5 mmol) with a pipette , the reaction was stirred overnight at room temperature; the reacted solution was poured into 600 mL of water, and the pH of the mixture was adjusted to 4 by adding concentrated aqueous HCl dropwise; the precipitated orange solid was collected by suction filtration and washed with saturated NaHCO 3 Wash once with distilled water, and then freeze-dry with a freeze dryer (-50°C, 7-8Pa) to obtain the desired orange powder product, namely the azobenzene crosslinking agent.
[0051] S2, preparation of composite hydrogel drug carrier:
[0052] Add hydroxyethyl methacrylate (HEMA, 2.5 mL) into a 10 mL centrifuge tube, mix and shake well, then add azobenzene cross-linking agent (2.54 mg) to the mixture and shake...
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