Unlock instant, AI-driven research and patent intelligence for your innovation.

Nano liposome containing hydrophilic drug core and preparation method of nano liposome

A technology of nano-liposomes and hydrophilic drugs, which is applied in the directions of liposome delivery, medical preparations of inactive ingredients, and drug combinations, etc., can solve the problems of affecting the stability of liposomes and reducing the drug load of drugs, etc. , to achieve the effect of improving stability and drug loading, beneficial to industrial production, and simple preparation process

Inactive Publication Date: 2020-11-27
JIANGXI WENTANGLAO FOOD
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the strong hydrophobicity of lycopene and its long carbon chain structure, which is similar to the hydrophobic carbon chain structure of phospholipids, it will greatly affect the stability of liposomes in the lipid phase and reduce the drug's efficacy. Drug loading

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Nano liposome containing hydrophilic drug core and preparation method of nano liposome
  • Nano liposome containing hydrophilic drug core and preparation method of nano liposome
  • Nano liposome containing hydrophilic drug core and preparation method of nano liposome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The lycopene albumin nano liposome has the following composition in terms of mass percentage: 10% lycopene, 20% bovine serum albumin, 55% soybean lecithin, and 15% cholesterol.

[0023] Concrete preparation steps are as follows:

[0024] (1) Preparation of lycopene-albumin complex: Weigh a specific weight of lycopene and bovine serum albumin and dissolve them in chloroform, with a mass volume ratio of 20%, and place them in a round bottom flask. After mixing and incubating for 30 minutes, chloroform was evaporated on a rotary evaporator under reduced pressure, and purified water was added for hydration to obtain a lycopene-albumin complex with a mass concentration of 10% (w / v).

[0025] (2) Preparation of lycopene-albumin nanoliposomes: Weigh a specific weight of soybean lecithin, dissolve cholesterol in a mixed solvent of ether-n-hexane with a volume ratio of 9:1, and slowly use a syringe during ultrasonication in a water bath. Inject the aqueous solution dissolved wi...

Embodiment 2

[0028] The lycopene albumin nano liposome has the following composition in terms of mass percentage: 10% lycopene, 20% bovine serum albumin, 60% soybean lecithin, and 10% cholesterol.

[0029] Concrete preparation steps are as follows:

[0030] (1) Preparation of lycopene-albumin complex: Weigh a specific weight of lycopene and bovine serum albumin and dissolve them in chloroform, with a mass volume ratio of 30%, and place them in a round bottom flask. After mixing and incubating for 30 minutes, chloroform was evaporated on a rotary evaporator under reduced pressure, and purified water was added for hydration to obtain a lycopene-albumin complex with a mass concentration of 10% (w / v).

[0031] (2) Preparation of lycopene-albumin nanoliposomes: Weigh a specific weight of soybean lecithin, dissolve cholesterol in a mixed solvent of ether-n-hexane with a volume ratio of 9:1, and slowly use a syringe during ultrasonication in a water bath. Inject the aqueous solution dissolved wi...

Embodiment 3

[0034] The lycopene albumin nano liposome has the following composition in terms of mass percentage: 8% lycopene, 15% bovine serum albumin, 62% soybean lecithin, and 15% cholesterol.

[0035] Concrete preparation steps are as follows:

[0036] (1) Preparation of lycopene-albumin complex: Weigh a specific weight of lycopene and bovine serum albumin and dissolve them in chloroform, with a mass volume ratio of 20%, and place them in a round bottom flask. After mixing and incubating for 30 minutes, chloroform was evaporated on a rotary evaporator under reduced pressure, and purified water was added for hydration to obtain a lycopene-albumin complex with a mass concentration of 10% (w / v).

[0037] (2) Preparation of lycopene-albumin nanoliposomes: Weigh a specific weight of soybean lecithin, dissolve cholesterol in a mixed solvent of ether-n-hexane with a volume ratio of 9:1, and slowly use a syringe during ultrasonication in a water bath. Inject the aqueous solution dissolved wit...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to the field of a pharmaceutical preparation, in particular to nano liposome containing a hydrophilic drug core and a preparation method of the nano liposome. The preparation method mainly comprises the steps that a drug / albumin mixture is formed after a hydrophobic drug and albumin liposome are mixed, the drug is combined with albumin through Van der Waals force, hydrophilcity of the drug can be improved, the liposome is further prepared, so that not only can influence of the hydrophobic drug on stability of the liposome be avoided, but also the drug is encapsulated intothe aqueous phase in the liposome, and drug loading capacity and bioavailability of the drug are improved.

Description

technical field [0001] The application relates to the field of pharmaceutical preparations, in particular to a nanoliposome containing a hydrophilic drug core and a preparation method thereof. Background technique [0002] Lycopene is a carotenoid. Lycopene from natural sources mainly exists in the most stable all-trans structure, as shown in the following formula. It has multiple antioxidant effects and is widely used as a drug. Tumor, anti-inflammatory effect, etc. Because it contains polyunsaturated conjugated double bonds, it is easy to react with oxygen and become an ineffective component, thereby reducing its antioxidant effect. [0003] [0004] The lycopene molecule contains 11 conjugated and 2 non-conjugated double bonds, and its stability is very poor, and it is prone to cis-trans isomerization and oxidative degradation. Unstable and easily destroyed by oxidation. Light, oxygen, metal ions, temperature, pH, etc. will affect the stability of lycopene. Because...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/01A61K47/64A61P29/00A61P35/00
CPCA61K31/01A61K9/127A61K47/643A61P35/00A61P29/00
Inventor 李琎杰彭再生
Owner JIANGXI WENTANGLAO FOOD