Polymer brush with bacterial responsiveness and preparation method thereof

Abstract

The invention provides a preparation method of a polymer brush with bacterial responsiveness. Compared with the prior art, the polymer brush has the advantages that the double-layer surface is constructed by adopting an ultraviolet-initiated living polymerization mode, so the obtained polymer brush has a double-layer structure with an antibacterial adhesion layer at an upper layer and an antibacterial brush layer at a lower layer, the surface is endowed with excellent blood compatibility and cell compatibility, the characteristic of antibacterial adhesion is also realized, and the probabilityof bacterial adhesion is effectively reduced; and meanwhile, an anion-cation charge reversal mechanism adopted by the invention has high stability under physiological conditions, no antibacterial substances are leached out, drug resistance of bacteria can be avoided, and the anion-cation charge reversal mechanism has higher sensitivity than a traditional charge neutralization mechanism under bacterial acidification conditions, can efficiently release a loaded antibacterial agent, and plays a role in rapid sterilization.

Description

technical field [0001] The invention belongs to the technical field of antibacterial surface construction, and in particular relates to a polymer brush with bacteria responsiveness and a preparation method thereof. Background technique [0002] During the storage, implantation or use of medical devices, bacteria may adhere to the surface of the material, thereby forming a biofilm and eventually causing bacterial infection. Bacterial infection caused by medical devices is the main cause of nosocomial infection, and nosocomial infection significantly increases the morbidity and mortality of patients, and increases the economic burden of patients. [0003] At present, there are two main ways to endow medical devices with anti-bacterial infection performance: anti-bacterial adhesion and sterilization. Loading anti-bacterial adhesion substances on the surface of the material, such as polyethylene glycol, amphoteric organic internal salts and neutral polysaccharides, etc., can ef...

AI Technical Summary

Problems solved by technology

However, in this patent, UV-induced transfer-terminated polymerization (SI-PIMP) is used to construct the double-layer antibacterial surface. The thickness of the polymer brush is only a dozen to tens of nanometers, and it is difficult to effectively exert the antibacterial performance of the surface.

In addition, the double-layer surface adopts a structure in which the upper layer is sterilizing and the lower layer is anti-adhesive, while the process of bacterial infection is to adhere first and then grow, which will easily lead to bacterial adhesion and accumulation of dead bacteria, thereby affecting the antibacterial performance of the surface

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