Polymer brush with bacterial responsiveness and preparation method thereof

A polymer brush and responsive technology, applied in the field of bacteria-responsive polymer brushes and their preparation, can solve the problems of bacterial adhesion, affecting surface antibacterial properties, accumulation of dead bacteria, etc.

Active Publication Date: 2020-11-27
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in this patent, UV-induced transfer-terminated polymerization (SI-PIMP) is used to construct the double-layer antibacterial surface. The thickness of the polymer brush is only a dozen to tens of nanometers, and it is difficult to effectively exert the antibacterial performance of the surface.
In addition, the double-l

Method used

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  • Polymer brush with bacterial responsiveness and preparation method thereof
  • Polymer brush with bacterial responsiveness and preparation method thereof
  • Polymer brush with bacterial responsiveness and preparation method thereof

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preparation example Construction

[0042] The invention provides a method for preparing a polymer brush with bacteria responsiveness, comprising:

[0043] S1) Grafting a photoinitiator on the surface of the polymer substrate to obtain a photoinitiator-modified polymer substrate;

[0044] S2) placing the photoinitiator-modified polymer substrate in a responsive monomer solution, and ultraviolet light triggers graft polymerization to obtain a responsive precursor-modified polymer substrate;

[0045] S3) placing the responsive precursor-modified polymer substrate in an anti-adhesion monomer solution, and ultraviolet light triggers graft polymerization to obtain a responsive precursor-modified polymer substrate with anti-adhesion;

[0046] S4) Place the responsive precursor and the anti-adhesion co-modified polymer substrate in a carboxyl activator solution for activation, then place it in a diamine solution for reaction, and then put it in an acid anhydride solution for reaction, to obtain Polymer substrates co-m...

Embodiment 1

[0068] Plasma pretreatment was carried out on the low-density polyethylene film, and its working parameters were: power 100W, pressure 20Pa, gas flow rate 20cc / min, temperature 25°C, time 3min; then the pretreated sample was placed in 10.0wt% 2- In the isopropylthioxanthone acetone solution, 200W high-pressure mercury lamp was irradiated for 20min, and then the sample was washed with ethanol and deionized water for 20min successively under the condition of oscillating in a water bath at 100Hz, and then the sample was placed in 5.0wt% 2-carboxylate Ethacrylate aqueous solution, 200W high-pressure mercury lamp irradiation for 6 minutes, the sample was washed as above, placed in 10.0wt% hydroxyethyl methacrylate aqueous solution, 200W high-pressure mercury lamp irradiation for 6 minutes, the sample was washed as above, placed in 2.5wt% 2-morpholineethanesulfonic acid, 6.0wt% 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 3.0wt% N-hydroxysuccinimide (the three Rat...

Embodiment 2

[0078] Plasma pretreatment was carried out on the high-density polyethylene film, and its working parameters were: power 110W, pressure 30Pa, gas flow rate 30cc / min, temperature 27°C, time 4min; then the sample was placed in acetone with 11.0wt% thioxanthone In the solution, a 210W high-pressure mercury lamp was irradiated for 21 minutes, and then the sample was washed with ethanol and deionized water for 20 minutes successively under the condition of 110 Hz water bath oscillation, and then the sample was placed in 6.0wt% acrylic acid aqueous solution, and a 210W high-pressure mercury lamp was irradiated for 7 minutes. After cleaning as above, place in 11.0wt% acryloyloxyphosphorylcholine aqueous solution, 210W high-pressure mercury lamp irradiation for 7min, after cleaning the sample as above, place in (3-(benzo[d][1,3]dioxa -5-yl)-2-iodo-5-methoxyphenyl)boronic acid (concentration 12wt%) aqueous solution, reacted for 1.1h at a reaction temperature of 5°C, and then placed the ...

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Abstract

The invention provides a preparation method of a polymer brush with bacterial responsiveness. Compared with the prior art, the polymer brush has the advantages that the double-layer surface is constructed by adopting an ultraviolet-initiated living polymerization mode, so the obtained polymer brush has a double-layer structure with an antibacterial adhesion layer at an upper layer and an antibacterial brush layer at a lower layer, the surface is endowed with excellent blood compatibility and cell compatibility, the characteristic of antibacterial adhesion is also realized, and the probabilityof bacterial adhesion is effectively reduced; and meanwhile, an anion-cation charge reversal mechanism adopted by the invention has high stability under physiological conditions, no antibacterial substances are leached out, drug resistance of bacteria can be avoided, and the anion-cation charge reversal mechanism has higher sensitivity than a traditional charge neutralization mechanism under bacterial acidification conditions, can efficiently release a loaded antibacterial agent, and plays a role in rapid sterilization.

Description

technical field [0001] The invention belongs to the technical field of antibacterial surface construction, and in particular relates to a polymer brush with bacteria responsiveness and a preparation method thereof. Background technique [0002] During the storage, implantation or use of medical devices, bacteria may adhere to the surface of the material, thereby forming a biofilm and eventually causing bacterial infection. Bacterial infection caused by medical devices is the main cause of nosocomial infection, and nosocomial infection significantly increases the morbidity and mortality of patients, and increases the economic burden of patients. [0003] At present, there are two main ways to endow medical devices with anti-bacterial infection performance: anti-bacterial adhesion and sterilization. Loading anti-bacterial adhesion substances on the surface of the material, such as polyethylene glycol, amphoteric organic internal salts and neutral polysaccharides, etc., can ef...

Claims

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Application Information

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IPC IPC(8): C08J7/18C08J7/12C08L23/06C08L75/04C08L9/06
CPCC08J7/12C08J7/18C08J2309/06C08J2323/06C08J2375/04
Inventor 栾世方刘廷武闫顺杰周容涛殷敬华闫秋艳
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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