Use of a substrate coating for decreasing leakage of matter

A technology of coatings, substances, applied in the new application field of surface coatings to achieve improved antimicrobial effect and reduce leakage

Pending Publication Date: 2020-11-27
BACTIGUARD AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For some applications, another issue is how to reduce blood clotting when artificial materials come into contact with blood

Method used

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  • Use of a substrate coating for decreasing leakage of matter
  • Use of a substrate coating for decreasing leakage of matter
  • Use of a substrate coating for decreasing leakage of matter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0193] Prevent latex Foley catheters from leaking allergens.

[0194] For comparison, coated and uncoated Foley catheters of the same type and latex material were provided. Also, a different type of Foley catheter made of latex without any protein is provided as a reference.

[0195] Foley latex catheters to be coated were coated as follows: A layer of silver was deposited on Foley catheters as a substrate according to the following method. First, wash and rinse the Foley catheter in deionized water. The surface of the Foley catheter was activated by immersion in an aqueous stannous chloride solution, followed by rinsing in deionized water. The surface of the Foley catheter was then plated with silver by immersing it in 3 deposition solutions containing silver ions. The resulting silver surface was applied in an amount of 0.9 μg / cm 2 . Particles consisting of 60% by weight palladium and 40% by weight gold were then deposited on the first silver surface by immersion in a d...

Embodiment 2

[0203] Leakage of ions in titanium-nickel alloys and their corrosion resistance.

[0204] Nitinol, or nitinol, is composed of approximately equal parts titanium and nickel. A study was carried out to evaluate the corrosion resistance of nickel-titanium alloys coated according to the invention compared to untreated samples. Comparisons were made on samples shaped as tubes and sheets. The coating is produced by a process that provides a thin surface layer composed of the precious metals gold, palladium and silver.

[0205] First, nickel titanium (Nitinol) tubes / sheets were cleaned with deionized water and then rinsed. Activate the surface of the tube / piece by immersing in an aqueous stannous chloride solution, followed by rinsing in deionized water. The surface of the tube / sheet is then plated with a layer of silver by immersion in 3 deposition solutions containing silver ions. The silver surface thus produced was applied in an amount of 1.6 μg / cm 2 . A particle deposition...

Embodiment 3

[0213] Reduces bacterial growth on coated Nitinol.

[0214] Nickel titanium (Nitinol) was coated using the same method as in Example 2 with the same amount of Ag and metal ratio in the particles. Microbial adhesion of Staphylococcus aureus (S. aureus) was measured for uncoated control samples and coated samples.

[0215] 2560 CFU / cm for uncoated samples 2 , for coated samples, 285CFU / cm 2 . A reduction of about 88%. This demonstrates the ability of the coating to reduce the adhesion of microorganisms to the surface.

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PUM

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Abstract

There is provided a method for decreasing leakage of matter from an object to a surrounding, said object being coated with a coating at least partially applied on the object, said coating comprising an at least partially covering layer comprising silver, said object optionally comprising area(s) without said layer, said coating comprising metal particles applied on the layer and optionally on areas without said layer, said metal particles comprising palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, niobium, neodymium and platinumand wherein the amount of the metal particles is in the interval 0.01-8 [mu]g/cm2. Advantages include that leakage of matter such as latex allergens of metal ions can be reduced while the coating is both biocompatible and antimicrobial. Further, the blood clotting can be reduced.

Description

technical field [0001] The present invention relates to a novel application of surface coatings for minimizing leakage of various substances from coated objects. The coating is both antimicrobial and exhibits biocompatibility at least for blood clotting. Background technique [0002] Antimicrobial and biocompatible surfaces are important in many applications. Among others, examples of surfaces where these properties are important include surfaces intended to come into contact with the human or animal body, including surfaces that come into contact with the skin as well as body cavities and bodies. [0003] It is known in the art that leakage of substances from polymers, including eg from gloves made of eg latex or other polymeric materials, is a problem related eg to allergies. Spilled substance may cause sensitization in sensitive persons. Latex allergies started to increase in the 1980s, when healthcare workers started using latex gloves. [0004] Another example is me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30A61L29/10A61L31/08A61L15/18A61L17/14
CPCA61L15/18A61L17/145A61L27/306A61L29/106A61L31/088A61L2300/404A61L2300/42A61L33/022C23C20/04C23C28/023C23C28/021A61L2300/104A61L2420/02A61L27/047C08L7/02A61L17/06A61L17/10A61L27/165A61L29/042A61L31/049A61L2300/802A61L2430/12A61L2430/20A61L2430/24C09D1/00C09D5/38
Inventor B·索德沃尔J·桑切斯
Owner BACTIGUARD AB
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