Soft porous silica gel ocular prosthesis pedestal and preparation method thereof

A technology of porous silica gel and prosthetic eye seat, which is applied in medical science, prosthesis, tissue regeneration, etc., can solve the problem that the prosthetic eye seat cannot meet the non-rigid material and high material requirements, and achieve matching mechanical strength and microstructure and biological Stability, easy availability, good biocompatibility

Active Publication Date: 2020-12-22
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to overcome the problems existing in the existing prosthetic eye sockets in the background technology, the purpose of the present invention is to provide a soft porous silica gel prosthetic eye socket and its preparation method, which solves the problem that the conventional prosthetic eye socket cannot meet non-rigid materials and has high material requirements at the same time. question

Method used

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  • Soft porous silica gel ocular prosthesis pedestal and preparation method thereof
  • Soft porous silica gel ocular prosthesis pedestal and preparation method thereof
  • Soft porous silica gel ocular prosthesis pedestal and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0046] 1) Use a standard sieve of 180-280 μm to obtain gelatin particles with a particle size range of 180-280 μm, fill the gelatin particles with a hemispherical polytetrafluoroethylene template with a diameter of 15 mm, add 85% ethanol solution until penetration is complete, 40 ° C Hemispherical templates were obtained by constant temperature drying, and gelatin particle spherical templates with a diameter of 15 mm were obtained after secondary bonding and assembly.

[0047] 2) Mix the silica gel prepolymer and curing agent evenly at a ratio of 10:1, centrifuge at high speed to remove the gas in the prepolymer mixture, and introduce the gelatin template obtained in step 1) under negative pressure. Solidify at 80°C for 1 hour, cool naturally, soak in deionized water, replace the deionized water every 5 hours, keep in a constant temperature water bath at 37-40°C for 2 days, remove the gelatin template, and obtain a soft porous silicone prosthetic eye seat.

[0048] as attached...

Embodiment 2

[0053] The preparation method is the same as in Example 1, the difference is that the gelatin particle size in step 1) is changed to 280-450 μm, and the ratio of silica gel prepolymer and curing agent in step 2) is adjusted to 5:1. By changing the size of the porogen , The ratio of prepolymer and curing agent regulates the size of the hole size of the silicone eye socket ( image 3 A, image 3 B) and mechanical properties.

example 3

[0055] The preparation method is the same as that in Example 1, the difference is that based on the internal structure of the silicone eye socket, a 40mg / mL fibrinogen solution is introduced into the internal hole structure of the eye socket, and thrombin with a working concentration of 25U / mL is added, and cross-linked at 37°C for 1 Hours, freeze-dried to obtain fibrin-modified silica gel eye sockets ( Image 6 ).

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Abstract

The invention discloses a soft porous silica gel ocular prosthesis pedestal and a preparation method thereof. The soft porous silica gel ocular prosthesis pedestal is prepared from a silica gel material and has a high-porosity interpenetrating porous structure, and microcosmic pores in the surface and the interior of the porous material are uniformly distributed and communicate with one another; the preparation method comprises the following steps of sequentially adding a half amount of gelatin particles into a semispherical polytetrafluoroethylene mold, permeating by using an ethanol aqueoussolution, performing drying at constant temperature, performing bonding and molding, mixing a silica gel prepolymer with a cross-linking agent, and carrying out uniformly mixing under mechanical stirring to obtain a silica gel prepolymer mixture; and introducing the negative-pressure silica gel prepolymer mixture into a spherical gelatin template for cross-linking and curing, and removing the template in a constant-temperature water bath to obtain the soft porous silica gel ocular prosthesis pedestal. The pure silica gel ocular prosthesis pedestal is high in biocompatibility and biological stability, controllable in pore diameter, high in pore connectivity and extremely high in porosity, the survival rate of implants is increased through structural and mechanical property optimization, andpostoperative complications are reduced; and the method is simple and low in material cost.

Description

technical field [0001] The invention belongs to a medical implant material, and relates to a design and construction method of a functional tissue engineering support material, in particular to a soft porous silica gel prosthetic eye seat and a preparation method thereof. Background technique [0002] Functional tissue engineering (FTE) is a novel field that emphasizes the importance of mechanical stress for the construction of tissue engineered complexes and its impact on tissue remodeling in vivo. Even in non-loadbearing tissues and organs, the biomechanics and mechanobiology between cells and material scaffolds are crucial to regulate cell\tissue behavior. Understanding the role of physical factors in regulating cell growth, differentiation, and metabolism is of great significance in affecting the outcome of tissue / organ damage and repair, and has become an important research hotspot in functional tissue engineering. [0003] In clinical work, trauma-induced eyeball irre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/18A61L27/26A61L27/50
CPCA61L27/18A61L27/26A61L27/50A61L27/56A61L2430/16C08L83/04C08L89/00
Inventor 叶娟徐佩芳曹静冯雪
Owner ZHEJIANG UNIV
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