Antioxidant starch-based dextrin composite nanoparticle, and preparation method and application thereof

A technology of composite nanoparticles and oxidized dextrin, which is applied in application, climate change adaptation, cosmetic preparations, etc., can solve the problems of thermodynamic instability and application limitations of multiple emulsions, and achieve easy industrial production, simple preparation method, strong resistance The effect of oxidation properties

Active Publication Date: 2020-12-25
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its application is greatly limited due to the thermodynamically unstable properties of multiple emulsions due to the flocculation, coalescence and migration of inner and outer aqueous phase components of oil droplets.

Method used

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  • Antioxidant starch-based dextrin composite nanoparticle, and preparation method and application thereof
  • Antioxidant starch-based dextrin composite nanoparticle, and preparation method and application thereof
  • Antioxidant starch-based dextrin composite nanoparticle, and preparation method and application thereof

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preparation example Construction

[0029] One aspect of the embodiments of the present invention provides a method for preparing antioxidant starch-based dextrin composite nanoparticles, which includes:

[0030] The first mixed reaction system comprising gliadin, ferulic acid, sodium hydroxide, ethanol and water was reacted at 25° C. for 24 hours to obtain a covalent complex of gliadin-ferulic acid, and then the The second mixed reaction system of gliadin-ferulic acid covalent complex, sodium carbonate, ethanol and water was reacted at 25°C for 4 hours to obtain hollow gliadin-ferulic acid nanoparticles;

[0031] Reacting the third mixed reaction system comprising oxidized dextrin, ferulic acid, ethanol and water at 80°C for 2 hours to obtain the oxidized dextrin-ferulic acid covalent complex;

[0032] And, the fourth mixed reaction system comprising the hollow gliadin-ferulic acid nanoparticles, the oxidized dextrin-ferulic acid covalent complex and water was reacted at 25° C. for 2 hours to obtain the hollow ...

Embodiment 1

[0114] (1) Preparation of hollow gliadin-ferulic acid nanoparticles

[0115] Dissolve gliadin and ferulic acid in 80% (v / v) ethanol solution respectively, adjust the pH value to 9.0 with 0.1mol / L sodium hydroxide solution after mixing, and continuously stir the reaction at 25°C After 24 hours, after the reaction was completed, the obtained mixed solution was ultrasonically dialyzed in a water bath for 24 hours, during which the dialysate was changed 8 times to remove free ferulic acid, and finally the solution was freeze-dried to obtain gliadin-ferulic acid covalent complexes;

[0116] 2g gliadin-ferulic acid covalent complex was dissolved in 100mL ethanol solution (volume fraction 80%), and stirred at 800rpm for 2h, left to stand until completely dissolved, while 2wt% sodium carbonate aqueous solution was mixed with anhydrous Ethanol is uniformly mixed at a volume ratio of 3:7 to form an ethanol suspension of sodium carbonate, and the above suspension is mixed with a gliadin...

Embodiment 2

[0130] (1) Preparation of hollow gliadin-ferulic acid nanoparticles

[0131] Dissolve gliadin and ferulic acid in 80% (v / v) ethanol solution respectively, adjust the pH value to 9.0 with 0.1mol / L sodium hydroxide solution after mixing, and continuously stir the reaction at 25°C After 24 hours, after the reaction was completed, the obtained mixed solution was ultrasonically dialyzed in a water bath for 24 hours, during which the dialysate was changed 8 times to remove free ferulic acid, and finally the solution was freeze-dried to obtain gliadin-ferulic acid covalent complexes;

[0132] 2g gliadin-ferulic acid covalent complex was dissolved in 100mL ethanol solution (volume fraction 80%), and stirred at 800rpm for 2h, left to stand until completely dissolved, while 2wt% sodium carbonate aqueous solution was mixed with anhydrous Ethanol is uniformly mixed at a volume ratio of 3:7 to form an ethanol suspension of sodium carbonate, and the above suspension is mixed with a gliadin...

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Abstract

The invention discloses an antioxidant starch-based dextrin composite nanoparticle, and a preparation method and application thereof. The invention also discloses a preparation method of a multiple emulsion. The preparation method of the multiple emulsion comprises the following steps of mixing polyglycerol polyricinoleate and colza oil at 65 DEG C to form a first oil phase; then, mixing a mixed solution of sodium chloride and gelatin used as a first water phase with the obtained first oil phase, and performing high-pressure homogenization treatment to obtain a W2 / O2 type primary emulsion; mixing a second oil phase with a nanoparticle suspension used as a second water phase, and performing high-pressure homogenization treatment to prepare an O1 / W1 type Pickering emulsion; and then, mixingthe O1 / W1 type Pickering emulsion with the W2 / O2 type primary emulsion, and performing high-pressure homogenization treatment to obtain the W2 / O2 / (O1 / W1) type multiple emulsion. The preparation methodof the multiple emulsion provided by the invention has the advantages of simplicity and mild reaction conditions, is suitable for industrial production, and can be applied to the fields of food, medicine, cosmetics and the like.

Description

technical field [0001] The invention belongs to the field of emulsification technology, and specifically relates to an anti-oxidation starch-based dextrin composite nanoparticle and its preparation method and application, in particular to a hollow gliadin-ferulic acid / oxidized dextrin-ferulic acid nanoparticle Particle and preparation method thereof, and hollow gliadin-ferulic acid / oxidized dextrin-ferulic acid nanoparticles in the preparation of W 2 / O 2 / (O 1 / W 1 ) Application in multiple emulsions. Background technique [0002] As an antioxidant with a strong free radical scavenging rate, polyphenols have been extensively studied in the fields of food and medicine in recent years. However, the multiple phenolic hydroxyl groups contained in polyphenols make them unstable to light, high temperature and alkaline conditions, and their bioavailability is also reduced. Many studies have shown that the covalent attachment of polyphenols to biopolymers may increase their ph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K9/113A61K47/36A61K47/42A61K47/12A61K8/02A61K8/06A61K8/64A61K8/365A61K8/73A61Q19/00A23L29/00A23L29/30
CPCA61K9/19A61K9/113A61K47/36A61K47/42A61K47/12A61K8/0225A61K8/066A61K8/64A61K8/365A61K8/73A61Q19/00A23L29/045A23L29/015A23L29/035A23L29/35A23V2002/00A23V2250/54A23V2250/1614A23V2250/082A23V2250/5114A23V2250/18Y02A40/90
Inventor 章宝孟然刘文杰李小龙廖文莹
Owner HEFEI UNIV OF TECH
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