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Application of lixisenatide in the preparation of antitumor drugs

An anti-tumor drug, lixisenatide technology, applied in the field of tumor treatment, can solve the problem of no lixisenatide, no immune activation or anti-tumor immune activation data or results, etc., to inhibit tumor growth, delay metastasis and recurrence , the effect of prolonging survival

Active Publication Date: 2021-06-22
NANJING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there is no report of lixisenatide being used for tumor treatment or anti-tumor, nor is there any data or results of immune activation or anti-tumor immune activation.

Method used

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  • Application of lixisenatide in the preparation of antitumor drugs
  • Application of lixisenatide in the preparation of antitumor drugs
  • Application of lixisenatide in the preparation of antitumor drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Detection of the immune activation function of polypeptide drugs on peripheral blood mononuclear cells

[0024] 1. Experimental method

[0025] 1. Determination of screening objects

[0026] We used the DrugBank database to search for peptide drugs, excluding FDA-approved peptides for the treatment of infectious diseases, treatment of blood system diseases, tumor therapy and immune regulation, and the functions of the approved peptides are not related to tumor therapy and immune regulation Relationship. The functions focus on the treatment of hormone disorders, treatment of sexual dysfunction, treatment of diabetes, treatment of gastrointestinal diseases, treatment of genetic diseases, treatment of cardiovascular diseases, treatment of bone diseases, treatment of nervous system diseases, treatment of respiratory disorders, treatment of eye disorders, treatment of absorption bad disease. This includes peptide drugs for diabetes treatment. In addition, the s...

Embodiment 2

[0036] Example 2 Observation of the therapeutic effect of lixisenatide on a normal mouse melanoma model

[0037] 1. Experimental method

[0038] We used normal healthy mice C57BL / 6, mice with sound immunity and normal blood sugar, mainly wanting to bear tumors (melanoma model) on mice with sound immunity and normal blood sugar, and then observe the therapeutic effect and immune activation. Since it is tumor-bearing in mice with sound immunity and normal blood sugar, if lixisenatide is effective, then such a function does not depend on its existing function-lowering blood sugar.

[0039] A 6-8 week old C57BL / 6 mouse was selected to establish a subcutaneous melanoma model in the right axilla. Each mouse was inoculated with 5×10 6 A B16 / F10 melanoma cell, the tumor size was measured to about 200mm after about 6 days 3 , the mice were randomly divided into 2 groups, 12 in each group, respectively: PBS control group (100 μl PBS) and lixisenatide subcutaneous injection treatment ...

Embodiment 3

[0046] Example 3 Observation of the therapeutic effect of lixisenatide subcutaneous injection on a normal mouse breast cancer model

[0047] 1. Experimental method

[0048] We used normal healthy BALB / c female mice with healthy immune system and normal blood sugar. We mainly want to carry tumors (breast cancer model) on mice with healthy immune system and normal blood sugar, and then observe the therapeutic effect and immune activation . Since it is tumor-bearing in mice with sound immunity and normal blood sugar, if lixisenatide is effective, then such a function does not depend on its existing function-lowering blood sugar.

[0049] BALB / c female mice aged 6-8 weeks were selected to establish a subcutaneous breast cancer model in the right axillary fat pad. Each mouse was inoculated with 5×10 6 4T1 breast cancer cells in mice, the tumor size was measured to about 200mm after about 8 days 3 , the mice were randomly divided into 2 groups, 12 in each group, respectively: PB...

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Abstract

The invention relates to the field of tumor treatment, in particular to the use of lixisenatide in the preparation of antitumor drugs. The invention discloses the effect of lixisenatide on immune activation, and the effect on anti-tumor immune activation; also discloses the effect of lixisenatide on anti-tumor immunotherapy. The results of the present invention show that lixisenatide can significantly stimulate the proliferation of immune cells, which can significantly stimulate the release of interferon gamma (IFN-γ); on multiple in vivo animal tumor-bearing models, lixisenatide can significantly inhibit tumor growth, Significantly prolong the survival period of tumor-bearing mice; lixisenatide can significantly prolong the survival period of mice with metastatic and recurrent tumors after surgery, and since lixisenatide itself is a marketed drug, its safety is basically guaranteed. In conclusion, lixisenatide can be used to prepare antitumor drugs.

Description

technical field [0001] The invention relates to the field of tumor treatment, in particular to the immune activation effect and anti-tumor application of lixisenatide. Background technique [0002] Tumor is a major disease that threatens human health. Traditional surgery, radiotherapy, chemotherapy and other programs can inhibit tumor progression to a certain extent, but it is difficult to control tumor recurrence and metastasis. With the emerging exciting clinical research results, anti-tumor immunotherapy has brought hope to cancer patients. The immune system has the ability to recognize and eliminate dissidents. In the process of tumor development, it not only suppresses the innate immune response of the immune system through various methods, but also restricts the "display" of its own "new" antigens and activates immune checkpoints. To "paralyze" the infiltrating immune effector cells, so as to achieve the purpose of evading immune recognition and immune clearance. Ho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/26A61P35/00A61P37/04A61P35/04
CPCA61K38/26A61P35/00A61P35/04A61P37/04
Inventor 吴俊华张姗江春平刘淑雯马丁魏继武石维维王忠夏张广曹胤
Owner NANJING UNIV
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