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Hydrogen-rich physiological seawater nasal spray and preparation method thereof

A physiological seawater and hydrogen-rich technology, applied in the field of medical supplies, can solve problems such as complex composition of physiological seawater preparations, allergic reactions in patients with damaged nasal mucosa, and ineffective improvement of rhinitis, so as to reduce the degree of ischemic and hypoxic brain damage, Effect of reducing cell damage and few side effects

Pending Publication Date: 2021-01-01
XIAMEN CHITOSAN BIO TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pure use of physiological seawater, used as a non-drug treatment, can improve clinical symptoms caused by acute, chronic, allergic rhinitis and nasal cavity surgery, but after regular application of physiological seawater nasal spray, its improvement effect on rhinitis less and less obvious
Various essential oils, auxiliary drugs or other preparations are often added to some existing physiological seawater preparations to increase the effect, but this also makes the composition of physiological seawater preparations complex, and some preparations may even easily cause allergic reactions in patients with damaged nasal mucosa

Method used

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  • Hydrogen-rich physiological seawater nasal spray and preparation method thereof
  • Hydrogen-rich physiological seawater nasal spray and preparation method thereof
  • Hydrogen-rich physiological seawater nasal spray and preparation method thereof

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Embodiment 1

[0027] This embodiment is a kind of hydrogen-rich physiological seawater nasal spray. The prescription is: an appropriate amount of deep seawater, add purified water to 12000mL, and make 400 bottles. The preparation method includes the following steps:

[0028] 1) Add seawater about 40% of the total volume of the batching container, add 0.1% (w / v) activated carbon according to the concentrated volume, and heat to boiling;

[0029] 2) Use a 0.45 μm microporous membrane for coarse filtration, and then use a 0.22 μm microporous membrane to filter until the visible foreign matter is qualified;

[0030] 3) Use 20% (w / w) sodium hydroxide to adjust the pH value between 6.0-7.5, add purified water to the full amount, and test the sodium ion content to obtain physiological sea water;

[0031] 4) After passing the salt content inspection, cool down the physiological seawater solution to below 20°C;

[0032] 5) Under the specific atmospheric pressure of 0.4mPa, 100% concentration of hyd...

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Abstract

The invention discloses a hydrogen-rich physiological seawater nasal spray and a preparation method thereof. The preparation method comprises the following steps: 1) adding activated carbon into deepsea water, and performing heating to boiling; 2) filtering the heated deep sea water with a micro-porous filter membrane to remove macroscopic foreign matters; 3) adding a pH regulator to regulate thepH value of the deep sea water to 6.0-8.0, then performing diluting with purified water, and performing stirring to obtain a physiological seawater solution, wherein the pH regulator is sodium hydroxide, potassium hydroxide or sodium bicarbonate; (4) cooling the physiological seawater solution to be not higher than 20 DEG C after the pH value and foreign matters are inspected to be qualified; 5)blending hydrogen into the physiological seawater solution under the atmospheric pressure of 0.4-0.5 mPa at the temperature of 20 DEG C through the diffusion effect, and performing continuous pressurizing for at least 6 h to enable hydrogen in the solution to be in a maximum saturation state to obtain hydrogen-rich physiological seawater; and 6) performing filling. The hydrogen-rich physiologicalseawater nasal spray disclosed by the invention has very good improvement effects on acute, chronic and allergic rhinitis, and clinical symptoms caused after the nasal surgery.

Description

technical field [0001] The invention belongs to the technical field of medical supplies, and in particular relates to a hydrogen-rich physiological seawater nasal spray and a preparation method thereof. Background technique [0002] Physiological seawater is hypertonic saline, free of antibiotics, preservatives, and hormones. Deep sea water contains a large amount of minerals and seawater trace elements (copper, manganese, zinc, silver, etc.), and its main component is 0.9% sodium chloride seawater solution, because its osmotic pressure value is close to that of plasma and tissue fluid of normal people. Good compatibility with nasal cavity. Physiological seawater contains silver, zinc, manganese, copper and other trace elements, among which zinc and silver are considered to be "sterilizing", copper is considered to be "anti-inflammatory element", and manganese is considered to be "anti-allergic element". Antibacterial, antiviral, antiallergic, anti-inflammatory effects. P...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K47/02A61K35/08A61P11/02A61P37/08
CPCA61K9/0043A61K9/12A61K47/02A61K35/08A61P11/02A61P37/08
Inventor 侯振清侯鲁朱富凯张欣
Owner XIAMEN CHITOSAN BIO TECH
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