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Traditional Chinese medicine formula granule formula containing salvia miltiorrhiza formula granules and application thereof

A technology of traditional Chinese medicine formula granules and salvia miltiorrhiza formula granules, which is applied in the direction of medical formulas, drug combinations, and medical preparations containing active ingredients, etc., can solve the problems of limited clinical efficacy and ineffective drug effects, and achieve the effect of treating symptoms

Active Publication Date: 2021-01-08
山东宏济堂制药集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the clinical methods of western medicine to treat thin endometrium mainly include oral administration of a large amount of estrogen, gonadotropin-releasing hormone agonist, aspirin, sildenafil and other drugs. surgery, but the clinical efficacy is limited

Method used

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  • Traditional Chinese medicine formula granule formula containing salvia miltiorrhiza formula granules and application thereof
  • Traditional Chinese medicine formula granule formula containing salvia miltiorrhiza formula granules and application thereof
  • Traditional Chinese medicine formula granule formula containing salvia miltiorrhiza formula granules and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A traditional Chinese medicine formula granule composition containing Danshen formula granules. The traditional Chinese medicine formula granule formula containing Danshen formula granules consists of Danshen formula granules, yam formula granules, Rehmannia glutinosa formula granules, safflower formula granules, Alisma formula granules, angelica Composition of formula granules, Danshen formula granules are the monarch drug, yam formula granules are minister drugs, Rehmannia glutinosa formula granules, safflower formula granules, Alisma formula granules, and Angelica formula granules are adjuvant medicines.

[0029] The parts by weight of each component are as follows:

[0030]

[0031] The preparation method of the Danshen formula granule comprises:

[0032] Take a certain weight of Danshen decoction pieces, add water to decoct twice, add 15-30 times the weight of Danshen decoction pieces in water each time, decoct for about 30 minutes each time, combine the two dec...

Embodiment 2

[0047] Toxicity test

[0048] Test materials: 1#, 2#, 3# Chinese medicine formula granules containing Salvia miltiorrhiza prepared according to Example 1.

[0049] Experimental animals: adult Kunming female mice, provided by the Experimental Animal Center of Shandong University.

[0050] (1) Acute toxicity

[0051] Take 30 Kunming mice, divide them into 1-3 groups, 10 in each group, administer 1# Chinese medicine formula granules containing Danshen formula granules to the first group of Kunming mice, and give 2# Chinese medicine formula granules containing Danshen formula granules to the group. The 2nd group of Kunming mice were administered with the prescription, and the 3rd group of Kunming rats were administered with the prescription of 3# Chinese medicine formula granules containing Danshen formula granules, and the dosage was 132 times of the clinical dosage of people (50kg). After 24 hours and 7 days of administration, no abnormalities were found in the activities of t...

Embodiment 3

[0055] clinical experiments

[0056] 1. Test materials: 1#, 2#, and 3# Chinese medicine formula granules containing Salvia miltiorrhiza prepared according to Example 1.

[0057] 2. Test basis: The test plan is based on "Measures for the Administration of Drug Registration", "Quality Management Practices for Drug Clinical Trials", "Adverse Drug Reaction Reporting and Monitoring Management Measures", "Guiding Principles for Clinical Research of New Chinese Medicines" edited by Zheng Xiaoyu "New Chinese Medicines Therapy "Guiding Principles of Clinical Research of Irregular Menstruation" and "Guiding Principles of Clinical Research of New Chinese Drugs for Treatment of Kidney-Yang Deficiency Syndrome", "Obstetrics and Gynecology" (8th Edition edited by Xie Xing, Gou Wenli) and "Gynecology of Traditional Chinese Medicine" (Ma Baozhang, Qi The ninth edition edited by Cong, the second edition edited by Zhang Yuzhen), and the formulation of relevant pharmacology and toxicology experi...

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Abstract

The invention discloses a traditional Chinese medicine formula granule formula containing salvia miltiorrhiza formula granules and application thereof. The traditional Chinese medicine formula granuleformula containing the salvia miltiorrhiza formula granules consists of salvia miltiorrhiza formula granule bodies, rhizoma dioscoreae formula granules, prepared rehmannia root formula granules, carthamus tinctorius formula granules, oriental waterplantain rhizome formula granules and angelicae sinensis formula granules. According to the traditional Chinese medicine formula granule formula containing the salviae miltiorrhizae formula granules, the salviae miltiorrhizae formula granule bodies are used as monarch drugs, the rhizoma dioscoreae formula granules are used as ministerial drugs, theprepared rehmannia root formula granules, the carthamus tinctorius formula granules, the oriental waterplantain rhizome formula granules and the angelicae sinensis formula granules are used as adjuvant drugs, and are mutually compatible and synergistically synergized to achieve the effects of tonifying kidney, replenishing essence, tonifying qi, nourishing blood and promoting blood circulation; and the traditional Chinese medicine formula granule formula containing the salviae miltiorrhizae formula granules can well treat thin endometrium and kidney-yang deficiency symptoms.

Description

technical field [0001] The application relates to a prescription of traditional Chinese medicine formula granules containing Danshen formula granules and its application. Background technique [0002] Thin endometrium usually refers to the peak day of urinary luteinizing hormone (LH) or when follicles mature (diameter ≥ 18mm) or the day of human chorionic gonadotropin (hCG) injection in ovulation induction cycle in natural cycle. Thickness≤7mm. The main clinical feature is that the menstrual cycle is normal, but the thin endometrium causes too little menstruation, which in turn affects embryo implantation, leads to infertility, and even increases the risk of spontaneous abortion. [0003] There is no record of thin endometrium in the ancient medical books of traditional Chinese medicine. According to its clinical manifestations, it can be classified into the categories of "hypomenorrhea", "infertility", and "amenorrhea". The understanding of its etiology and pathogenesis i...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K9/16A61P15/00A61P13/12
CPCA61K9/1652A61K36/232A61K36/286A61K36/537A61K36/804A61K36/884A61K36/8945A61K2236/331A61K2236/39A61P13/12A61P15/00A61K2300/00
Inventor 罗毅宋骁孟兆青李樱吕多森王延凤王丽丽王全军许加成李金鑫
Owner 山东宏济堂制药集团股份有限公司