A kind of method for enzymatic synthesis of (s)-2-aminobutanamide

A technology for aminobutanamide and enzymatic synthesis, which is applied in the field of enzymatic synthesis of -2-aminobutanamide, can solve the problems of low yield and few synthesis reports, and achieves high ee value, high stereoselectivity, and high specificity. sexual effect
CN112195203BActive Publication Date: 2022-07-26江苏八巨药业有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
江苏八巨药业有限公司
Publication Date
2022-07-26

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Abstract

The invention relates to a method for enzymatically synthesizing (S)-2-aminobutanamide, and belongs to the technical field of pharmaceutical intermediate synthesis. In order to solve the existing problem of adopting chemical synthesis method, a method for enzymatic synthesis of (S)-2-aminobutanamide is provided, the method comprises in the presence of an amino donor, under the action of a catalytic amount of lipase, The substrate (S)-2-aminobutyric acid methyl ester is subjected to catalytic aminolysis to obtain the corresponding product (S)-2-aminobutyramide; the gene sequence of the lipase is shown in SEQ ID NO.1. The present invention has high stereoselectivity and specificity, forms a product of S-type chiral configuration, and has the effects of high chiral purity and high ee value of the product.
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Description

technical field

[0001] The invention relates to a method for synthesizing (S)-2-aminobutanamide by an enzymatic method, and belongs to the technical field of pharmaceutical intermediate synthesis. Background technique

[0002] Levetiracetam (LEV, trade name Kaipulan) is a piracetam drug developed by Belgian UCB company, chemical name is (S)-а-ethyl-2-oxo-1- Pyrrolidineacetamide. Compared with traditional drugs for treating epilepsy, LEV has a new mechanism of action and can be used as an additive to treat various epilepsy in children, especially for complex localized seizures and myoclonic seizures. Compared with similar drugs, LEV has the following advantages: (1) There is a large difference between the effective dose and the toxic dose, the drug is safe, and the side effects are small; (2) The main metabolic pathway does not pass through the liver drug enzyme system, and there is no interaction with other antiepileptic drugs. ; (3) Rapid oral absorption, absolute bioavai...

Claims

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