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Application of 1-sulfonyl naphthol derivative in prevention and treatment of plant pathogenic fungi and antibacterial agent

A technology of phytopathogenic fungi, sulfonyl naphthol, applied in biocides, plant growth regulators, chemicals for biological control, etc., to achieve good antibacterial activity

Active Publication Date: 2021-01-15
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the bacteriostasis of 1-naphthol to Gibberella wheat still has a large gap compared with the existing environment-friendly fungicide hymexazol

Method used

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  • Application of 1-sulfonyl naphthol derivative in prevention and treatment of plant pathogenic fungi and antibacterial agent
  • Application of 1-sulfonyl naphthol derivative in prevention and treatment of plant pathogenic fungi and antibacterial agent
  • Application of 1-sulfonyl naphthol derivative in prevention and treatment of plant pathogenic fungi and antibacterial agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] The application of the 1-sulfonylnaphthol derivatives in this example in the control of phytopathogenic fungi is the application of compounds 1-16 in Table 1 in the control of phytopathogenic fungi.

[0058] The concrete structural formula of compound 1~16 of table 1 and the R group in the corresponding structural formula I

[0059]

[0060]

[0061]

[0062] The above compounds 1-16 are prepared by a method comprising the following steps:

[0063] 1) In a 100mL flask, add 5mmol of 1-naphthol, 5.5mmol of substituted sulfonyl chloride (i.e. compound of formula II), and add 20mL of dichloromethane to dissolve it completely, then slowly drop triethylamine (6mmol, Et 3 N) dichloromethane solution, stirring reaction at room temperature (r.t.) after dropping, TLC tracking monitoring to the end of the reaction;

[0064] 2) After the reaction is over, add 20mL of water to the reaction system, then use dichloromethane to carry out multiple extractions, combine the orga...

Embodiment 2

[0184] The antibacterial agent for preventing and treating phytopathogenic fungi of this embodiment, wherein the active ingredient is any one of compounds 1-16 in Table 1. When preparing the antibacterial agent for controlling plant pathogenic fungi in this example, refer to the preparation method of the existing antibacterial agent, and only replace the active ingredient with the compound selected as the active ingredient among compounds 1-16. For example, the active ingredient in the commercial antibacterial agent Hymexazol can be replaced with the compound selected as the active ingredient among compounds 1-16 at an equal concentration.

experiment example

[0186] This experimental example is an activity test for inhibiting plant pathogenic fungi:

[0187] 1. Plant pathogenic fungi tested (16 species in total): wheat scab [Fusarium graminearum Schw.], wheat root rot [Bipolaris sorokiniana (Sacc.) Shoem], wheat stem rot [Fusariumpseudogramminearum, Fpg], rice Rice blast fungus [Pyricularia oryzae Cav.], corn large spot fungus [Exserohilum turcicum (Pass.) Leonard et Suggs], corn small spot fungus [Helminthosporium maydis Nisik&Miy], corn Currularia lunata (Boed) Wakker], Sclerotinia sclerotiorum (Lib.) de Bary], Fusarium oxysporum (Schlecht) f.sp. nicotianae (Johns.) Snyder et Hansen], Phytophoranicotianae Breda de Haan Tuker, Alternaria alternata Keissler, Fusarium oxysporium f.sp.Vasinfectum synder et Hansen, Fusarium oxysporium f.sp cucumbererinum Owen, Botrytis cinereaPers., Black cabbage Spot fungus [Alternaria brassicae Sacc.] and Capsicum phytophthora [Phytophthoracapsici Leonian] were provided by the Laboratory of Plant P...

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Abstract

The invention relates to application of a 1-sulfonyl naphthol derivative in prevention and treatment of plant pathogenic fungi and an antibacterial agent, and belongs to the technical field of antibacterial agents. In the application of the 1-sulfonyl naphthol derivative, the 1-sulfonyl naphthol derivative has a structure shown as a formula I, and in the formula I, R is C1-C6 alkyl, aryl or heteroaryl, wherein the aryl is phenyl, substituent substituted phenyl or naphthyl. In the application of the 1-sulfonyl naphthol derivative of the present invention, the 1-sulfonyl naphthol derivative canbe used for detecting 16 plant pathogenic fungi such as fusarium graminearum, wheat root rot fungi, wheat stem rot fungi, magnaporthe oryzae, setosphaeria turcica, bipolaris maydis, maize curvularia leaf spot, oilseed rape sclerotinia sclerotiorum, tobacco fusarium oxysporum, phytophthora nicotianae, alternaria alternata, cotton fusarium oxysporum, cucumber fusarium oxysporum and botrytis cina, alternaria brassicae and phytophthora capsici, and shows good antibacterial activity.

Description

technical field [0001] The invention relates to the application of 1-sulfonyl naphthol derivatives in the prevention and treatment of plant pathogenic fungi and an antibacterial agent, belonging to the technical field of antibacterial agents. Background technique [0002] 1-Naphthol belongs to polycyclic aromatic hydrocarbons (Polycyclic Aromatic Hydrocarbons, PAHs) substances, mainly used in organic synthesis and dye engineering, and is an important intermediate in pesticide, medicine, dyestuff, cosmetics and other industries. 1-Naphthol has a broad spectrum of agricultural biological activities, and has activities such as insecticide, antibacterial, and growth inhibition of Chlorella vulgaris. In particular, 1-Naphthol has been used as a raw material for the insecticide carbaryl for a long time, and has been used in large quantities. [0003] The antibacterial activity of 1-naphthol has been reported in the literature, such as Zhou Ji et al. in "Preparation of emulsifiable...

Claims

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Application Information

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IPC IPC(8): A01N41/04A01N43/10A01N43/42A01P3/00
CPCA01N41/04A01N43/10A01N43/42
Inventor 陈根强车志平田月娥刘圣明胡梅姜佳张嵩朱丽娜李元昊郭小龙
Owner HENAN UNIV OF SCI & TECH
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