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An anti-infection electrospinning degradable hernia prosthesis and preparation method thereof

An electrospinning and anti-infection technology, which is applied in the direction of electrospinning, filament/thread forming, textiles and papermaking, etc., can solve the problems of easy shedding of antibacterial substances, poor anti-infection effect, unfavorable growth of new capillaries and wounds Repair and other issues

Active Publication Date: 2021-09-07
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to prevent postoperative infection, adding antibacterial drugs to the mesh can better achieve the purpose of postoperative antibacterial, but the antibacterial substances in the existing hernia mesh are easy to fall off, and the anti-infection effect is not good; and because the aperture of the hernia mesh Small size is not conducive to the growth of new capillaries and wound repair, and may also prevent the passage and infiltration of macrophages to cause infection

Method used

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  • An anti-infection electrospinning degradable hernia prosthesis and preparation method thereof
  • An anti-infection electrospinning degradable hernia prosthesis and preparation method thereof
  • An anti-infection electrospinning degradable hernia prosthesis and preparation method thereof

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preparation example Construction

[0030] The invention provides a preparation method of an anti-infection electrospinning degradable hernia patch, comprising the following steps:

[0031] mixing polyurethane solution, gallic acid and polyvinyl alcohol to obtain a spinning solution;

[0032] Electrospinning the spinning solution to obtain a spun film;

[0033] The spinning film is soaked in water, and the polyvinyl alcohol is dissolved to obtain an anti-infection electrostatic spinning degradable hernia patch.

[0034] The invention mixes polyurethane solution, gallic acid and polyvinyl alcohol to obtain spinning solution. In the present invention, the preparation method of the polyurethane solution preferably includes the following steps: mixing diisocyanate, polycaprolactone and an organic solvent to carry out polycondensation reaction to obtain a prepolymer; Mixed with organic tin catalyst, a chain extension reaction occurs to obtain a polyurethane solution.

[0035] In the present invention, it is prefer...

Embodiment 1

[0052] 10g of polycaprolactone with a number average molecular weight of 30000, 0.758g of diphenylmethane diisocyanate and 21.952g of dimethylformamide were put into a machine equipped with mechanical stirring, reflux condenser and N 2 In the three-necked flask with inlet and outlet, magnetically stir until dissolved, and in N 2 Polycondensation reaction at 80°C for 3 hours under protection to obtain a prepolymer;

[0053] Add 0.218g of 1,4-butanediol to the above prepolymer, drop 2 to 3 drops of dibutyltin dilaurate, and conduct a chain extension reaction at 110°C for 9 hours to obtain a transparent polyurethane solution with a solid content of 25%. ;

[0054] Mix 3 g of the polyurethane solution, 0.009 g of gallic acid and 0.5 g of a 10 wt % polyvinyl alcohol aqueous solution, homogenize under ultrasonic conditions (ultrasonic power is 60 W, time is 2 h), to obtain a spinning solution;

[0055] Set up the spray table, put the spinning solution into a 5mL syringe in the spr...

Embodiment 2

[0059] Put 10g of polycaprolactone with a number average molecular weight of 20000, 0.758g of dicyclohexylmethane diisocyanate and 21.952g of tetrahydrofuran into a device equipped with mechanical stirring, reflux condenser and N 2 In the three-necked flask with inlet and outlet, magnetically stir until dissolved, and in N 2 Polycondensation reaction at 70°C for 4 hours under protection to obtain a prepolymer;

[0060] Add 0.218g of 1,4-butanediol to the above prepolymer, drop 2 to 3 drops of dibutyltin dilaurate, and conduct a chain extension reaction at 90°C for 10 hours to obtain a transparent, high-viscosity, solid content of 25%. Polyurethane solution;

[0061] Mix 3 g of the polyurethane solution, 0.027 g of gallic acid and 0.7 g of a 10 wt % polyvinyl alcohol aqueous solution, homogenize under ultrasonic conditions (ultrasonic power is 80 W, time is 1 h), to obtain a spinning solution;

[0062] Set up the spray table, put the spinning solution into a 5mL syringe in th...

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Abstract

The invention relates to the technical field of hernia mesh preparation, in particular to an anti-infection electrospun degradable hernia mesh and a preparation method thereof. The invention provides a preparation method of an anti-infection electrospinning degradable hernia mesh, comprising the following steps: mixing polyurethane solution, gallic acid and polyvinyl alcohol to obtain a spinning solution; performing electrospinning on the spinning solution silk to obtain a spun film; the spun film is soaked in water, and the polyvinyl alcohol is dissolved to obtain an anti-infection electrostatic spinning degradable hernia mesh. In the present invention, polyvinyl alcohol is used as a sacrificial layer, which is dissolved in water after spinning and forming, which can improve the pore size and porosity on the basis of ensuring the overall structural integrity of the hernia patch, which is beneficial to inhibit infection; in addition, polyurethane can completely Degradation, gallic acid as a cross-linking agent can improve the strength and elasticity of polyurethane, and can also improve the antibacterial properties of hernia mesh.

Description

technical field [0001] The invention relates to the technical field of hernia mesh preparation, in particular to an anti-infection electrospun degradable hernia mesh and a preparation method thereof. Background technique [0002] Inguinal hernia is a common and frequently-occurring disease in general surgery. Traditional hernia repair has gradually faded out of people's field of vision due to many postoperative complications, especially the high postoperative recurrence rate. The tension-free repair of inguinal hernia is more effective than traditional surgery. The method has obvious advantages, but there are still many complications caused by the existing mesh, among which infection is the most common complication. The incidence of infection after abdominal incisional hernia is 4-16%, while the incidence of infection after other clean operations There are 2%. Wound infection significantly increases the risk of hernia recurrence. Studies have found that the recurrence rate ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/26D06B3/10D04H1/4382D04H1/728D01D5/00A61L27/54A61L27/58
CPCA61L27/26A61L27/54A61L27/58A61L2300/216A61L2300/414D01D5/003D01D5/0061D01D5/0069D01D5/0092D04H1/4382D04H1/728D06B3/10C08L75/04C08L29/04
Inventor 张耀明李兆龙周栋王齐华王廷梅崔超强
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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