Preparation method of traditional Chinese medicine composition for treating chronic benign gastropathy and esophageal diseases

A composition and a technology for esophageal disease, applied in the field of traditional Chinese medicine, can solve the problems of affecting the exertion of medicinal effect, many impurities, increasing the preparation cost, etc., and achieve the effects of improving the utilization value, reducing the use cost, and saving traditional Chinese medicine resources.

Pending Publication Date: 2021-01-22
YANTAI UNIV +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] The defects or deficiencies of the traditional Chinese medicine preparation method in the prior art are mainly reflected in the following aspects: when the current Chinese medicine preparation is prepared, the active ingredients are lost too much in the water extraction process, especially the water-insoluble components; The organic solvent in the medium may interact with the active ingredients, making it lose its original effect; the non-effective ingredients cannot be removed to the maximum extent, and the concentration rate is not high enough; in addition to the active ingredients, there are often many impurities in the extract, and there is still a small amount of fat-soluble ingredients, which will bring disadvantages to refining; high temperature operation will cause a large amount of decomposition of heat-sensitive active ingredients; at present, most traditional Chinese medicine preparations need to add a large amount of excipients in the preparation process, which increases the preparation cost and affects the efficacy to a certain extent
And the residue left by the general preparation method is often discarded, which is not conducive to environmental protection

Method used

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  • Preparation method of traditional Chinese medicine composition for treating chronic benign gastropathy and esophageal diseases
  • Preparation method of traditional Chinese medicine composition for treating chronic benign gastropathy and esophageal diseases
  • Preparation method of traditional Chinese medicine composition for treating chronic benign gastropathy and esophageal diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A traditional Chinese medicine composition for treating chronic benign stomach disease and esophageal disease, characterized in that it is prepared from the following raw materials by weight:

[0048] The steps of this embodiment are as follows:

[0049] (1), preparation of culture medium: 94g of traditional Chinese medicine composition for the treatment of chronic benign stomach disease and esophageal disease was prepared in proportion, including 10g of Codonopsis pilosula, 10g of fried Atractylodes macrocephala, 10g of Poria cocos, 6g of bergamot, 6g of citron, 6g of citrus aurantium, and citrus aurantium 6g of dulcis seed, 6g of seabuckthorn, 6g of perilla leaf, 6g of black plum, 6g of Daidaihua, 6g of ginger pinellia, 10g of licorice. The traditional Chinese medicine composition is divided into four 300mL conical flasks, and 33.4 mL of sterile water, 2.25 g of bran and 2.25 g of Artemisia annua are added in each conical flask;

[0050] (2) Sterilization: Put the ab...

Embodiment 2

[0059] In this example, on the basis of Example 1, the fermentation system enlarged to 30 L is carried out on a small-scale industrial preparation, and the steps are as follows:

[0060] (1), preparation of culture medium: 4.32 kg of traditional Chinese medicine composition for the treatment of chronic benign stomach disease and esophageal disease were prepared in proportion (the proportion of each Chinese medicine raw material was the same as in Example 1), and then 2.6 L of sterile water and 405 g of bran were added. skin and 405 g Artemisia annua, the prepared culture medium is divided into 7 aseptic feeders;

[0061] (2) Sterilization: put the above-mentioned aseptic feeder into a sterilizing pot, and sterilize for 20 minutes under the conditions of 121°C and 0.12 MPa high pressure;

[0062] (3), inoculation: put the above-mentioned sterilized traditional Chinese medicine composition into the fermentation system that has been sterilized by using a sterile feeder, and inocu...

experiment example 1

[0071] Experimental example 1: Mice to promote gastrointestinal motility experiment

[0072] 1.1 Experimental method

[0073] 1.1.1 Atropine modeling experiment

[0074] 50 3-week-old male Kunming mice, weighing 18-20 g. After adaptive feeding for 1 week, the mice were randomly divided into normal control group, model group (atropine group), sample high, medium and low dose groups (sample + atropine). Purified water is used as a solvent. Sample concentrated solution (equivalent to 20 g / kg crude drug, the same below), 10 g / kg (equivalent to 10 g / kg crude drug, the same below), 5 g / kg (equivalent to In crude drug 5 g / kg, the same below). Continuous gavage for 15 days. The normal control group and the model group were given the same volume of pure water by intragastric administration.

[0075] 1.1.2 L-arginine modeling experiment

[0076] 50 3-week-old male Kunming mice, weighing 18-20 g. After 1 week of adaptive feeding, the mice were randomly divided into normal control...

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Abstract

The invention discloses a preparation method of a traditional Chinese medicine composition for treating chronic benign gastropathy and esophageal diseases. The preparation method comprises the following steps: (1) preparing a culture medium: proportionally preparing the traditional Chinese medicine composition for treating the chronic benign gastropathy and esophageal diseases, putting the traditional Chinese medicine composition into a culture container, and adding sterile water, bran and sweet wormwood herb to the culture container; (2) sterilization; (3) inoculation: taking out the culturecontainer from a sterilization container, and inoculating edible and medicinal aspergillus CICC41649; (4) fermentation: carrying out static culture on the inoculated traditional Chinese medicine composition in a fermentation device at 29-31 DEG C for 4-9 days until the fermentation is completed; and (5) decoction: carrying out decoction to obtain a liquid medicine product. Microorganisms are introduced in the preparation process, the absorption rate of the medicine is increased, the toxic and side effects of the medicine are reduced, and the curative effect of the medicine is enhanced.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a preparation method of a traditional Chinese medicine composition for treating chronic benign stomach disease and esophageal disease. Background technique [0002] The defects or deficiencies of the traditional Chinese medicine preparation method in the prior art are mainly reflected in the following aspects: when the current Chinese medicine preparation is prepared, the active ingredients are lost too much in the water extraction process, especially the water-insoluble components; The organic solvent in the medium may interact with the active ingredients, making it lose its original effect; the non-effective ingredients cannot be removed to the maximum extent, and the concentration rate is not high enough; in addition to the active ingredients, there are often many impurities in the extract, and there is still a small amount of fat-soluble The high-temperature operat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8888A61P1/00A61P1/04
CPCA61K36/344A61K36/284A61K36/076A61K36/752A61K36/72A61K36/185A61K36/535A61K36/736A61K36/8888A61K36/484A61P1/00A61P1/04A61K2236/19
Inventor 林剑于帆高永林郭尽力孙喜灵张涛范庆波衣维元
Owner YANTAI UNIV
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