Multifunctional injectable hydrogel and preparation method thereof
A multi-functional, water-injection technology, applied in the field of biomaterials and biomedical engineering, can solve the problems of susceptibility to infection, and achieve the effects of fast gelation, simple preparation process, and good biocompatibility
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Embodiment 1
[0015] 1) Synthesis of GelMA: Weigh 5g of gelatin and add it to 50mL of PBS solution, stir in a constant temperature water bath at 60°C until completely dissolved to make a gelatin solution with a concentration of 10% w / v, drop 3mL of MA at a rate of 0.5mL / min Add to the gelatin solution, and continue to react at 50°C for 3h; add 250mL PBS solution to the above reaction solution, stir for 30min and then terminate the reaction; place the reacted solution in a 12-14kDa dialysis bag, and deionize at 40°C Dialyze in water for 6 days, centrifuge at 10,000rpm for 10min, collect the supernatant, freeze-dry after pre-freezing, and obtain a white solid;
[0016] 2) Preparation of Ce-BG NPs: Mix 80 mL of absolute ethanol and 20 mL of deionized water, and add 4 g of DDA to the solution at a constant temperature of 40 °C, and stir for 10 min to form a uniform and transparent mixed solution; Add 15.9mL of TEOS at a rate of 0.5mL / min and stir for 30min to form a milky white solution; in the...
Embodiment 2
[0019] 1) Synthesis of GelMA: Weigh 5g of gelatin and add it to 50mL of PBS solution, stir it in a constant temperature water bath at 60°C until it is completely dissolved to make a gelatin solution with a concentration of 10% w / v, drop 4mL of MA at a rate of 0.5mL / min Add to the gelatin solution, and continue to react at 50°C for 3h; add 250mL PBS solution to the above reaction solution, stir for 30min and then terminate the reaction; place the reacted solution in a 12-14kDa dialysis bag, and deionize at 40°C Dialyze in water for 6 days, centrifuge at 10,000rpm for 10min, collect the supernatant, freeze-dry after pre-freezing, and obtain a white solid;
[0020] 2) Preparation of Ce-BG NPs: Mix 80 mL of absolute ethanol and 20 mL of deionized water, and add 4 g of DDA to the solution at a constant temperature of 40 °C, and stir for 10 min to form a uniform and transparent mixed solution; Add 15.9mL of TEOS at a rate of 0.5mL / min and stir for 30min to form a milky white solutio...
Embodiment 3
[0023] 1) Synthesis of GelMA: Weigh 5g gelatin and add it to 50mL PBS solution, stir it in a constant temperature water bath at 60°C until it is completely dissolved to make a gelatin solution with a concentration of 10% w / v, drop 5mL MA at a rate of 0.5mL / min Add to the gelatin solution, and continue to react at 50°C for 3h; add 250mL PBS solution to the above reaction solution, stir for 30min and then terminate the reaction; place the reacted solution in a 12-14kDa dialysis bag, and deionize at 40°C Dialyze in water for 6 days, centrifuge at 10,000rpm for 10min, collect the supernatant, freeze-dry after pre-freezing, and obtain a white solid;
[0024]2) Preparation of Ce-BG NPs: Mix 80 mL of absolute ethanol and 20 mL of deionized water, and add 4 g of DDA to the solution at a constant temperature of 40 °C, and stir for 10 min to form a uniform and transparent mixed solution; Add 15.9mL of TEOS at a rate of 0.5mL / min and stir for 30min to form a milky white solution; in the ...
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