Micro-droplet operating system based on surface acoustic wave chip array

Abstract

A micro-droplet operating system based on a surface acoustic wave chip array comprises a plurality of interdigital transducer array units arranged on a lithium niobate substrate. Each interdigital transducer array unit comprises four independent interdigital transducer arrays evaporated above the lithium niobate substrate, the interdigital transducer arrays are arranged in a bilateral and longitudinal symmetry mode, and a central reaction tank is arranged in the middle. The upper portions of the interdigital transducer arrays are covered with inert carrier liquid in a soaking mode to serve asdiaphragm layers, liquid drops are arranged on the diaphragm layers, and the interdigital transducer arrays are connected with a signal control circuit through an electrode circuit. The signal controlcircuit comprises a signal generation module, the signal generation module generates sine wave signals, four paths of signals with adjustable frequency amplitudes are output through a parallel processing circuit, and a power amplification module acts the amplified four paths of signals on the interdigital transducer arrays to realize driving, mixing and splitting of liquid drops. Free movement ofliquid drops on the surfaces of the diaphragm layers is achieved, repeatability and integration are high, and large-scale application can be achieved.

Description

Technical field[0001]The invention belongs to the technical field of micro-droplet operating systems, and specifically relates to a micro-droplet operating system based on a surface acoustic wave chip array.Background technique[0002]Application of micro-nano manufacturing technology, especially surface acoustic wave technology, integrates the operation of micro-droplets of biochemical reagents in a small space, which can realize the miniaturization and portability of the micro-droplet operating system, and can perform a variety of micro-droplets such as blood , Saliva, driving and mixing of enzyme-containing reagents. The integration of microfluidic chips and integrated circuits makes it easy to realize miniaturization and automation of instruments.[0003]Traditional biological reagent detection is to extract biological samples, mix and stand in a reaction tank, and then detect the content of specific biomarkers after the reactants are fully mixed. However, some biological reagent re...

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Problems solved by technology

However, some biological reagent reactions (detection of neuron-specific enolase NSE) have defects such as damage to cell biocompatibility, mixing uniformity, and long reaction time of the mixture, which limits the first-time detection in the clinical medical process.

[0004] At present, the microfluidic technology for microdroplet processing often uses one or two interdigital transducers to generate acoustic waves to explore the driving effect, which leads to low repeatability and integration of microfluidic chip technology, making it impossible to achieve large-scale applications.

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